Results 221 to 230 of about 389,745 (325)

PFKM‐Driven Lactate Overproduction Promotes Atrial Fibrillation via Triggering Cardiac Fibroblasts Histone Lactylation

Advanced Science, EarlyView.
The upregulation of PFKM activates glycolysis, thereby enhancing lactate production in atrial tissue. Atrial lactate accumulation promotes global lactylation and H3K18 lactylation in atrial fibroblasts. P300‐mediated H3K18 lactylation up‐regulates TGF‐β1 transcription, leading to fibroblast activation and thereby contributing to atrial fibrosis.
Ning Fang, Ning Zhang, Xiaohui Jiang, Sen Yan, Zhiqi Wang, Qianhui Gao, Mingcheng Xu, Lin Mu, Xiaoming Li, Jiuling Chen, Song Zhang, Yu Duan, Fengxiang Yun, Luyifei Li, Yun Zhang, Yongtai Gong   +15 more
wiley   +1 more source

TET dioxygenases localize at splicing speckles and promote RNA splicing. [PDF]

Nucleus
Hastert FD, Weber J, Bauer C, Zhadan A, Singh DND, Dix TC, Arnold R, Bessonov S, Soller M, Leonhardt H, Cardoso MC, Arroyo M.   +11 more
europepmc   +1 more source

In vivo evolution of a catalytic RNA couples trans-splicing to translation. [PDF]

PLoS One, 2014
Olson KE, Dolan GF, Müller UF.
europepmc   +1 more source

Mutations of POLR3A Encoding a Catalytic Subunit of RNA Polymerase Pol III Cause a Recessive Hypomyelinating Leukodystrophy [PDF]

, 2011
Geneviève Bernard, Éliane Chouery, Maria Lisa Putorti, Martine Tétreault, Asako Takanohashi, Giovanni A. Carosso, I Clément, Odile Boespflug‐Tanguy, Diana Rodriguez, Valérie Delague, Joelle Abou Ghoch, Nadine Jalkh, Imen Dorboz, Sébastien Fribourg, Martin Teichmann, André Mégarbané, Raphael Schiffmann, Adeline Vanderver, Bernard Brais   +18 more
openalex   +1 more source

Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8‐AS1/GPX4 Axis in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
PAX8‐AS1 drives chemoresistance in intrahepatic cholangiocarcinoma by activating NRF2‐mediated GPX4 transcription and stabilizing GPX4 mRNA via IGF2BP3. Targeting the PAX8‐AS1/GPX4 axis with a GPX4 inhibitor enhances the efficacy of gemcitabine and cisplatin in preclinical models, offering a promising strategy to overcome chemotherapy resistance in ...
Zhi‐Wen Chen, Ji‐Jun Shan, Mo Chen, Zong Wu, Yi‐Ming Zhao, Hong‐Xu Zhu, Xin Jin, Yi‐Xiu Wang, Yi‐Bin Wu, Zhen Xiang, Zhi‐Wen Ding, Zhen‐Hai Lin, Long‐Rong Wang, Lu Wang   +13 more
wiley   +1 more source

The PAZ pocket and dimerization drive CpAgo's guide-independent and DNA-guided dual catalysis. [PDF]

Nat Commun
Liu Y, Zhang J, Liu J, Zhang S, An L, Xie W, Zhang K, Li S.   +7 more
europepmc   +1 more source

Functional Identification of Catalytic Metal Ion Binding Sites within RNA

, 2005
James L. Hougland, Alexander V. Kravchuk, Daniel Herschlag, Joseph A. Piccirilli   +3 more
openalex   +2 more sources

The Contribution of Peripheral Stem-Loops to the Catalytic Activity of Archaeal RNase P RNA fromPyrococcus horikoshiiOT3 [PDF]

, 2011
Tadashi HARA, Atsushi Terada, H Yamaguchi, Takashi Nakashima, Yoshimitsu Kakuta, Makoto Kimura   +5 more
openalex   +1 more source

Osteoblast‐CD4+ CTL Crosstalk Mediated by SIRT1/DAAM2 Axis Prevents Age‐Related Bone Loss

Advanced Science, EarlyView.
In the osteoblastic niche, SIRT1 activates and recruits CD4+ CTLs by increasing DAAM2 expression via EZH2 deacetylation and boosting the secretion of key chemokines, such as CCL3, CCL5, and CXCL10. Then, CD4+ CTL directly eliminates senescent osteoblasts in an MHC‐II‐dependent way, thereby slowing down the process of bone ageing and effectively ...
Bin Yang, Guofu Zhang, Yizhou Zhu, Jingcheng Wang, Xinmin Feng, Wenyong Fei, Jihang Dai, Le Hu, Yi Zhang, Jun Cai, Binjia Ruan, Yue Jin, Fanhao Wei, Gang Lu, Dongan Wang, Jason Pui Yin Cheung, Graham Ka Hon Shea, Hao Chen, Kelvin Wai Kwok Yeung, Lei Wang, Yongxiang Wang   +20 more
wiley   +1 more source

CryoEM structure of the SLFN14 endoribonuclease reveals insight into RNA binding and cleavage. [PDF]

Nat Commun
Van Riper J, Martinez-Claros AO, Wang L, Schneiderman HE, Maheshwari S, Pillon MC.   +5 more
europepmc   +1 more source