Results 251 to 260 of about 389,745 (325)

Endogenous Ribonucleases: Therapeutic Targeting of the Transcriptome Through Oligonucleotide-Triggered RNA Inactivation. [PDF]

Biomolecules
Chiglintseva DA, Patutina OA, Zenkova MA.   +2 more
europepmc   +1 more source

Hydrogen‐Producing Catalysts Based on Ferredoxin Scaffolds

Advanced Science, EarlyView.
Selected plant‐type ferredoxins that lack their natural [2Fe‐2S] clusters functionally bind a hydrogenase active site cofactor and act as hydrogenases themselves. In combination with photosystem I, the light‐dependent H₂ evolution almost matches the H₂ production rates of the natural system.
Yiting She, Vera Engelbrecht, Jacek Kozuch, Ulf‐Peter Apfel, Sven T. Stripp, Anja Hemschemeier, Thomas Happe   +6 more
wiley   +1 more source

The coming of age of DNA-based catalysts for therapeutic applications. [PDF]

Clin Transl Med
Hesse R, Gertzen CGW, Schmuck JF, Böcker JD, Pandey P, Behn T, Ruth C, Riesner D, Kath-Schorr S, Lang PA, Gohlke H, Etzkorn M.   +11 more
europepmc   +1 more source

The De Novo Cytosine Methyltransferase DRM2 Requires Intact UBA Domains and a Catalytically Mutated Paralog DRM3 during RNA–Directed DNA Methylation in Arabidopsis thaliana

, 2010
Ian R. Henderson, Angélique Deleris, William T. Wong, Xuehua Zhong, Hang Gyeong Chin, Gregory A. Horwitz, Krystyna A. Kelly, Sriharsa Pradhan, Steven E. Jacobsen   +8 more
openalex   +2 more sources

Histone Demethylase UTX Suppresses Tumor Cell Proliferation by Regulating Stress Granules

Advanced Science, EarlyView.
These findings indicate that cytoplasmic UTX forms puncta and co‐localizes in stress granules (SGs) upon various stresses. UTX TPR‐domain‐dependently and demethylase‐activity‐independently destabilize SGs by binding G3BP1, the SG hub protein, to disrupt SG network, thus affects tumorigenesis.
Xikai Liu, Xinran Liu, Mei Xue, Yushuo Xiao, Yuchen Chen, Rong Qiu, Di Wu, Yihao Zhou, Jiao Wang, Yan Yuan, Linwei Yu, Tianyi Shi, Yangkai Li, Hua Su, Hong Chen, Yong Liu, Kun Huang, Ling Zheng   +17 more
wiley   +1 more source

Decoupling Global and Local Structural Changes in Self-aminoacylating Ribozymes Reveals the Critical Role of Local Structural Dynamics in Ribozyme Activity. [PDF]

JACS Au
Cheng YK, Chu HH, Yang NJ, Lai YC.
europepmc   +1 more source

Critical Role of IL1R2‐ENO1 Interaction in Inhibiting Glycolysis‐Mediated Pyroptosis for Protection Against Lethal Sepsis

Advanced Science, EarlyView.
The authors have discovered that intracellular interleukin 1 receptor 2 (IL1R2) negatively regulates pyroptosis and inflammation by inhibiting glycolysis in sepsis. Soluble IL1R2 is released from macrophages undergoing pyroptosis. IL1R2 acts as a novel negative regulator of glycolysis by interacting with enolase 1 (ENO1), thereby inhibiting gasdermin D
Chuyi Tan, Han Ma, Jespar Chen, Gaifeng Ma, Alok Jha, Sipin Tan, Yaxi Zhu, Meidong Liu, Ke Liu, Xianzhong Xiao, Monowar Aziz, Huan Chen, Ping Wang, Huali Zhang   +13 more
wiley   +1 more source

METTL9 sustains vertebrate neural development primarily via non-catalytic functions. [PDF]

Nat Commun
Codino A, Spagnoletti L, Olobardi C, Cuomo A, Santos-Rosa H, Palomba M, Margaroli N, Girotto S, Scarpelli R, Luan SL, Crocco E, Bianchini P, Bannister AJ, Gustincich S, Kouzarides T, Rizzo R, Barbieri I, Cremisi F, Vignali R, Pandolfini L.   +19 more
europepmc   +1 more source

Abnormal β‐Hydroxybutyrylation Modification of ARG1 Drives Reprogramming of Arginine Metabolism to Promote the Progression of Colorectal Cancer

Advanced Science, EarlyView.
Alterations in arginine metabolism and β‐hydroxybutyrylation (Kbhb) modifications play a critical role in tumor progression. This study reveals valuable insights into arginine metabolism reprogramming involving the ARG1‐Kbhb/P300/SLC3A2 signaling axis and uncovers an effective therapy combining BHB with ARG1 inhibitor through conventional enzymatic and
Chuman Lin, Zhiyang Li, Xiaotong Zhu, Wanbing Zhou, Xiansheng Lu, Jiali Zheng, Jie Lin   +6 more
wiley   +1 more source

TRIM21‐Mediated K11‐Linked Ubiquitination of ID1 Suppresses Tumorigenesis and Promotes Cuproptosis in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
ID1 is regulated by E3 ligase TRIM21, which adds non‐degradative K11‐linked ubiquitin at Lys91, disrupting ID1‐TCF12 binding and freeing TCF12 to upregulate copper transporter SLC31A1. Enhanced SLC31A1 elevates intracellular copper, triggers cuproptosis, and inhibits ESCC growth.
Lei Li, Yuqing Wang, Ruoxi Tian, Tianshuo Yang, Yaxin Liu, Baoen Shan, Lianmei Zhao   +6 more
wiley   +1 more source