Results 261 to 270 of about 389,745 (325)

Novel In Vitro Selection of <i>Trans</i>-Acting <i>BCL-2</i> mRNA-Cleaving Deoxyribozymes for Cancer Therapy. [PDF]

Cells
Basamshetty VV, Gangipangi VK, Kumar US, Shanthi Bhupathi S, Kaulagari SR, Giri P, Sinha S, Mohan U, Sdrimas K.   +8 more
europepmc   +1 more source

Mercaptophenylboronic Acid‐Mediated Nanozyme Immunochromatographic Assay for Simultaneous Detection of Respiratory Bacteria and Virus

Advanced Science, EarlyView.
This study developes a universal colorimetric ICA platform that integrates broad‐spectrum recognition by 4‐mercaptophenylboronic acid with dual signal enhancement—both colorimetric and catalytic—mediated by a biomimetic magnetic nanozyme. This platform, for the first time, enables simple, convenient, ultrasensitive, and simultaneous screening of ...
Qing Yu, Jiaxuan Li, Shuai Zheng, Yajin Hu, Benshun Tian, Meirou Lu, Bing Gu, Chongwen Wang   +7 more
wiley   +1 more source

DBR1 orchestrates the fate of lariat RNA: debranching-dependent turnover and function. [PDF]

Nucleic Acids Res
Tang Q, Liao D, Zheng B.
europepmc   +1 more source

RNA molecules with conserved catalytic cores but variable peripheries fold along unique energetically optimized pathways

, 2011
S. Mitra, Alain Laederach, B. L. Golden, R. B. Altman, M. Brenowitz   +4 more
openalex   +2 more sources

Engineered Cas12j‐8 is a Versatile Platform for Multiplexed Genome Modulation in Mammalian Cells

Advanced Science, EarlyView.
Engineered through structure‐guided protein engineering, enCas12j‐8 significantly enhances the editing efficiency of compact Cas12j‐8 while maintaining high specificity. It enables efficient multiplexed genome editing and base editing using a single crRNA array, demonstrating broad applicability and therapeutic potential in genome engineering ...
Ru Meng, Jiayao Li, Wuke Wang, Dong Liang, Zhanwei Li, Cong Mao, Qingyang Li, Yu Zhang, Hao Chen, Jin Tang, Ping Hu, Qi Niu, Xingxu Huang, Bin Shen, Jun Zhang   +14 more
wiley   +1 more source

Engineering of Small Ribozymes Acting on RNA: What is Needed to Make a New Function Work with an Existing Catalyst? [PDF]

Chembiochem
Ebermann C, Müller S.
europepmc   +1 more source

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source

SARS-CoV-2 nsp15 enhances viral virulence by subverting host antiviral defenses. [PDF]

Proc Natl Acad Sci U S A
Caobi A, Su CM, Beusch CM, Kenney D, Darling TL, Feng S, Semaan M, Wacquiez A, Sanders NL, Tully ES, Chen DY, Evdokimova M, Ding Z, Jones D, Alysandratos KD, Mizgerd JP, Kirchdoerfer RN, Kotton DN, Douam F, Crossland NA, Boon ACM, Gordon DE, Baker SC, Saeed M.   +23 more
europepmc   +1 more source

Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA

, 2012
R.E. Haurwitz, Samuel H. Sternberg, Jennifer A. Doudna   +2 more
openalex   +2 more sources

PRO‐LDM: A Conditional Latent Diffusion Model for Protein Sequence Design and Functional Optimization

Advanced Science, EarlyView.
PRO‐LDM is a modular latent diffusion framework that learns hierarchical biological representations to enable efficient and high‐fidelity protein design. PRO‐LDM can design species that resemble natural sequences with enhanced diversity or optimize protein functions.
Sitao Zhang, Zixuan Jiang, Rundong Huang, Wenting Huang, Siyuan Peng, Shaoxun Mo, Letao Zhu, Peiheng Li, Ziyi Zhang, Emily Pan, Xi Chen, Yunfei Long, Qi Liang, Jin Tang, Renjing Xu, Rui Qing   +15 more
wiley   +1 more source