Results 81 to 90 of about 240,202 (291)

Specific catalytically impaired DDX3X mutants form sexually dimorphic hollow condensates

Nature Communications
Mutations in the RNA helicase DDX3X, implicated in various cancers and neurodevelopmental disorders, often impair RNA unwinding and translation. However, the mechanisms underlying the impairment and the differential interactions of DDX3X mutants with ...
Michael C. Owens, Hui Shen, Amber Yanas, Maria Saraí Mendoza-Figueroa, Ellen Lavorando, Xiaoyu Wei, Him Shweta, Hsin-Yao Tang, Yale E. Goldman, Kathy Fange Liu   +9 more
doaj   +1 more source

The catalytic mechanism of the RNA methyltransferase METTL3

eLife
The complex of methyltransferase-like proteins 3 and 14 (METTL3-14) is the major enzyme that deposits N6-methyladenosine (m6A) modifications on messenger RNA (mRNA) in humans.
Ivan Corbeski, Pablo Andrés Vargas-Rosales, Rajiv Kumar Bedi, Jiahua Deng, Dylan Coelho, Emmanuelle Braud, Laura Iannazzo, Yaozong Li, Danzhi Huang, Mélanie Ethève-Quelquejeu, Qiang Cui, Amedeo Caflisch   +11 more
doaj   +1 more source

Cryo-EM reveals an entangled kinetic trap in the folding of a catalytic RNA. [PDF]

Sci Adv, 2022
Bonilla SL, Vicens Q, Kieft JS.
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

The RNA World: Piecing together the historical development of a hypothesis

Mètode Science Studies Journal: Annual Review, 2016
The concept of an RNA world is a hypothesis firmly rooted in empirical data and is part of a long and complex scientific perspective that goes back more than fifty years to the discovery of the central role RNA and ribonucleotides play in protein ...
Antonio Lazcano
doaj   +1 more source

Catalytic RNA Oligomers Formed by Co-Oligomerization of a Pair of Bimolecular RNase P Ribozymes. [PDF]

Molecules, 2022
Siddika MA, Yamada T, Aoyama R, Hidaka K, Sugiyama H, Endo M, Matsumura S, Ikawa Y.   +7 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

The Application of Ribozymes and DNAzymes in Muscle and Brain

Molecules, 2010
The discovery of catalytic nucleic acids (CNAs) has provided scientists with valuable tools for the identification of new therapies for several untreated diseases through down regulation or modulation of endogenous gene expression involved in these ...
Leonidas A. Phylactou, James B. Uney, Nikolaos P. Mastroyiannopoulos   +2 more
doaj   +1 more source

Protein cofactors and substrate influence Mg2+-dependent structural changes in the catalytic RNA of archaeal RNase P. [PDF]

Nucleic Acids Res, 2021
Marathe IA, Lai SM, Zahurancik WJ, Poirier MG, Wysocki VH, Gopalan V.   +5 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source