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Lancet, The, 2007
Narcolepsy with cataplexy is a disabling sleep disorder affecting 0.02% of adults worldwide. It is characterised by severe, irresistible daytime sleepiness and sudden loss of muscle tone (cataplexy), and can be associated with sleep-onset or sleep-offset paralysis and hallucinations, frequent movement and awakening during sleep, and weight gain.
yves Dauvilliers, Isabelle Arnulf
exaly +3 more sources
Narcolepsy with cataplexy is a disabling sleep disorder affecting 0.02% of adults worldwide. It is characterised by severe, irresistible daytime sleepiness and sudden loss of muscle tone (cataplexy), and can be associated with sleep-onset or sleep-offset paralysis and hallucinations, frequent movement and awakening during sleep, and weight gain.
yves Dauvilliers, Isabelle Arnulf
exaly +3 more sources
Sleep Medicine Reviews, 2021
Cataplexy is the pathognomonic and the most striking symptom of narcolepsy. It has originally been, and still is now, widely considered as an abnormal manifestation of rapid eye movement (REM) sleep during wakefulness due to the typical muscle atonia. The neurocircuits of cataplexy, originally confined to the brainstem as those of REM sleep atonia, now
Ali Seifinejad +2 more
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Cataplexy is the pathognomonic and the most striking symptom of narcolepsy. It has originally been, and still is now, widely considered as an abnormal manifestation of rapid eye movement (REM) sleep during wakefulness due to the typical muscle atonia. The neurocircuits of cataplexy, originally confined to the brainstem as those of REM sleep atonia, now
Ali Seifinejad +2 more
openaire +2 more sources
American Journal of Psychiatry, 2004
Narcolepsy with cataplexy is a serious chronic neuropsychiatric disorder that typically begins at an early age. It has the potential to greatly disrupt social, educational, and vocational development. Because of the nature of its symptoms (e.g., excessive daytime sleepiness), narcolepsy provides insights into the mechanisms regulating human sleep.
Lois E, Krahn, Heydy L, Gonzalez-Arriaza
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Narcolepsy with cataplexy is a serious chronic neuropsychiatric disorder that typically begins at an early age. It has the potential to greatly disrupt social, educational, and vocational development. Because of the nature of its symptoms (e.g., excessive daytime sleepiness), narcolepsy provides insights into the mechanisms regulating human sleep.
Lois E, Krahn, Heydy L, Gonzalez-Arriaza
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Practical Neurology, 2018
Remarkably and almost invariably, the clinical phenomenon of cataplexy results from the loss of around 40 000 hypocretin-containing neurones in the lateral hypothalamus in the context of narcolepsy type 1. Cataplexy reflects the dysregulation of rapid-eye-movement (REM) sleep, such that REM-sleep atonia intrudes inappropriately into wakefulness as ...
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Remarkably and almost invariably, the clinical phenomenon of cataplexy results from the loss of around 40 000 hypocretin-containing neurones in the lateral hypothalamus in the context of narcolepsy type 1. Cataplexy reflects the dysregulation of rapid-eye-movement (REM) sleep, such that REM-sleep atonia intrudes inappropriately into wakefulness as ...
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Sleep Medicine Reviews, 2004
A variety of medications representing several major drug classes improve cataplexy in patients with narcolepsy. These include aminergic reuptake inhibitors such as venlafaxine and clomipramine as well as sodium oxybate. This review is intended to familiarize readers with the safety and efficacy of these medications, thus enabling clinicians to optimize
William C, Houghton +2 more
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A variety of medications representing several major drug classes improve cataplexy in patients with narcolepsy. These include aminergic reuptake inhibitors such as venlafaxine and clomipramine as well as sodium oxybate. This review is intended to familiarize readers with the safety and efficacy of these medications, thus enabling clinicians to optimize
William C, Houghton +2 more
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2011
Abstract The term “narcolepsy” was first coined by Gelineau in 1880 with the complete description of a patient with excessive daytime sleepiness (EDS), sleep attacks, and episodes of muscle weakness triggered by emotions. In the current international classification, narcolepsy is characterized by “excessive daytime sleepiness that is typically ...
Seiji, Nishino, Emmanuel, Mignot
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Abstract The term “narcolepsy” was first coined by Gelineau in 1880 with the complete description of a patient with excessive daytime sleepiness (EDS), sleep attacks, and episodes of muscle weakness triggered by emotions. In the current international classification, narcolepsy is characterized by “excessive daytime sleepiness that is typically ...
Seiji, Nishino, Emmanuel, Mignot
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Pharmacotherapy options for cataplexy
Expert Opinion on Pharmacotherapy, 2013Narcolepsy with cataplexy is a rare disabling sleep disorder characterized by two major symptoms: excessive daytime sleepiness and cataplexy characterized by a sudden bilateral loss of voluntary muscular tone triggered by strong positive emotional factors.
Régis, Lopez, Yves, Dauvilliers
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Archives of Neurology, 1974
Cataplexy, an abrupt and reversible paralysis, has been observed in 50 rapid eye movement (REM) sleep narcoleptics. The attacks lasted from a very few seconds to as long as 30 minutes. During attacks, the electroencephalogram remained similar to the normal base line awake EEG recorded previously in each patient; however, there were short periods where ...
C, Guilleminault +2 more
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Cataplexy, an abrupt and reversible paralysis, has been observed in 50 rapid eye movement (REM) sleep narcoleptics. The attacks lasted from a very few seconds to as long as 30 minutes. During attacks, the electroencephalogram remained similar to the normal base line awake EEG recorded previously in each patient; however, there were short periods where ...
C, Guilleminault +2 more
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Archives of Sexual Behavior, 1977
Ten married women with cataplexy were found to be rarely orgasmic. Cataplexy is characterized by recurrent episodes of short-lived generalized muscle paralysis. It is precipitated by arousing emotional precipitants such as laughter, fear, and anger. Patients learn to avoid situations exposing them to these precipitants.
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Ten married women with cataplexy were found to be rarely orgasmic. Cataplexy is characterized by recurrent episodes of short-lived generalized muscle paralysis. It is precipitated by arousing emotional precipitants such as laughter, fear, and anger. Patients learn to avoid situations exposing them to these precipitants.
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AGGRESSION, GUILT AND CATAPLEXY
American Journal of Psychiatry, 1953CATAPLEXY, a symptom of narcolepsy, is an illuminating example of paralysis of voluntary movement induced by emotion. In all the domain of psychosomatic medicine cataplexy is almost without a peer as a compelling illustration of how emotion can give rise, immediately and dramatically, to a physical symptom.
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