Results 1 to 10 of about 102,090 (142)

High-Throughput Transcriptomics of Celf1 Conditional Knockout Lens Identifies Downstream Networks Linked to Cataract Pathology

open access: yesCells, 2023
Defects in the development of the ocular lens can cause congenital cataracts. To understand the various etiologies of congenital cataracts, it is important to characterize the genes linked to this developmental defect and to define their downstream ...
Archana D. Siddam   +8 more
doaj   +1 more source

Autophagy in the eye: from physiology to pathophysiology

open access: yesAutophagy Reports, 2023
Autophagy is a catabolic self-degradative pathway that promotes the degradation and recycling of intracellular material through the lysosomal compartment. Although first believed to function in conditions of nutritional stress, autophagy is emerging as a
Paloma B. Liton   +15 more
doaj   +1 more source

Evaluation of the Influence of Clinical History on the Occurrence of Dementia Using the Database of National Health Insurance in Japan

open access: yesJournal of Ageing and Longevity, 2023
The global incidence of dementia has been rising for the past several years, posing significant health challenges regarding its management and prevention. Dementia is associated with a substantial burden on patients and their families.
Yoh Tamaki   +2 more
doaj   +1 more source

Zinc and Copper Ions Induce Aggregation of Human β-Crystallins

open access: yesMolecules, 2022
Cataracts are defined as the clouding of the lens due to the formation of insoluble protein aggregates. Metal ions exposure has been recognized as a risk factor in the cataract formation process. The γ and β crystallins are members of a larger family and
Vanesa Ramirez-Bello   +3 more
doaj   +1 more source

Pharmacologic pupillary constriction after dilated fundus examination for ectopia lentis to prevent further subluxation

open access: yesAmerican Journal of Ophthalmology Case Reports, 2020
Purpose: To describe two cases of ectopia lentis with different preoperative management strategies following the initial diagnostic dilated exam. Observations: In both cases, the patients presented with bilateral subluxation of the crystalline lens ...
William Plum   +5 more
doaj   +1 more source

Cataracts are Associated with the Coexistence of Moderate to Severe Obstructive Sleep Apnea and Diabetes Mellitus [PDF]

open access: yesSleep Medicine Research, 2020
Background and Objective The individual presence of diabetes mellitus (DM) or obstructive sleep apnea (OSA) is significantly associated with cataract formation, but few studies have examined the association of cataracts with comorbid DM and OSA.
Seungku Lee   +4 more
doaj   +1 more source

Prevalence and risk factors for cataracts in the Lao People's Democratic Republic: The Vientiane Eye Study

open access: yesIndian Journal of Ophthalmology, 2022
Purpose: To determine the prevalence and risk factors for cataracts in the Vientiane Province. Methods: We conducted a population-based study of 1264 participants aged ≥40 years of age from urban and rural areas of Vientiane Province.
Brad Guo   +6 more
doaj   +1 more source

Connexin Mutants Cause Cataracts Through Deposition of Apatite

open access: yesFrontiers in Cell and Developmental Biology, 2022
Cataracts are lens opacities that are among the most common causes of blindness. It is commonly believed that cataracts develop through the accumulation of damage to lens proteins.
Peter J. Minogue   +5 more
doaj   +1 more source

The Evolving Role of Ophthalmology Clinics in Screening for Early Alzheimer’s Disease: A Review

open access: yesVision, 2020
Alzheimer’s disease (AD) is the leading cause of dementia, which is a growing public health concern. Although there is no curative treatment for established AD, early recognition and modification of the known risk factors can reduce both severity and the
Paris Dickens, Kanna Ramaesh
doaj   +1 more source

Prevalence of pseudoexfoliation in diabetic patients with senile cataract: A hospital-based study in Kashmir, India

open access: yesIndian Journal of Ophthalmology, 2023
Purpose: To study the prevalence of pseudoexfoliation syndrome (PEX) in diabetics with senile cataracts and compare it to the prevalence in nondiabetic control group.
Sidra Javaid Thakur   +2 more
doaj   +1 more source

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