Results 51 to 60 of about 164,854 (240)

Restoring Glutathione Homeostasis in Glycation-Related Eye Diseases: Mechanistic Insights and Therapeutic Interventions Beyond VEGF Inhibition

open access: yesAntioxidants
Advanced glycation end-products (AGEs) and oxidative stress are recognized as central contributors to the pathogenesis of age-related or diabetic cataracts, diabetic retinopathy (DR), and age-related macular degeneration (AMD).
Yong Chool Boo
doaj   +1 more source

Cataract Blindness: Socioeconomic Factors Associated with Treatment Barriers and High Blindness Rates for Women in Rural Regions of Andhra Pradesh [PDF]

open access: yes, 2018
Despite efforts of Vision 2020 in India, the 2001 Andhra Pradesh Eye Disease Study (APEDS) extrapolated that approximately 18.7 million blind people resided in India and projected an increase to 31.6 million blind people by 2020.
Kaur, Kiranpreet
core   +1 more source

A novel mutation of p.F32I in GJA8 in human dominant congenital cataracts [PDF]

open access: yesInternational Journal of Ophthalmology, 2016
AIM: To identify a causative mutation in a three-generation family with autosomal dominant congenital total cataract and dissect the molecular consequence of the identified mutation.
Feng-Tao Dang   +8 more
doaj   +1 more source

Downregulation of AMPK dependent FOXO3 and TFEB involves in the inhibition of autophagy in diabetic cataract [PDF]

open access: bronze, 2021
Jiani Li   +6 more
openalex   +1 more source

A Rat Treated with Mesenchymal Stem Cells Lives to 44 Months of Age [PDF]

open access: yes, 2016
There is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine. We assessed the effect of intravenous administration of human bone marrow-derived MSC on the life span of a single Sprague-Dawley female
Goya, Rodolfo Gustavo   +4 more
core   +1 more source

A novel dominant mutation in CRYAB gene leading to a severe phenotype with childhood onset

open access: yesMolecular Genetics & Genomic Medicine, 2020
Background αB‐crystallin is a promiscuous protein involved in numerous cell functions. Mutations in CRYAB have been found in patients with different pathological phenotypes that are not properly understood.
Ana T. Marcos   +6 more
doaj   +1 more source

Polymorphisms in ARMS2/HTRA1 and complement genes and age-related macular degeneration in India: findings from the INDEYE study. [PDF]

open access: yes, 2012
PURPOSE: Association between genetic variants in complement factor H (CFH), factor B (CFB), component 2 (C2), and in the ARMS2/HTRA1 region with age-related macular degeneration (AMD) comes mainly from studies of European ancestry and case-control ...
Chakravarthy, Usha   +8 more
core   +1 more source

Current Trends in the Pharmacotherapy of Cataracts

open access: yesPharmaceuticals, 2020
Cataracts, one of the leading causes of preventable blindness worldwide, refers to lens degradation that is characterized by clouding, with consequent blurry vision.
Segewkal H. Heruye   +7 more
doaj   +1 more source

Primary radiotherapy in progressive optic nerve sheath meningiomas: a long-term follow-up study [PDF]

open access: yes, 2010
Background/aims: To report the outcome of primary radiotherapy in patients with progressive optic nerve sheath meningioma (ONSM). Methods: The clinical records of all patients were reviewed in a retrospective, observational, multicentre study.
Blank, L.   +8 more
core   +5 more sources

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