Results 101 to 110 of about 1,120,836 (288)
Analyzing Biomedical Datasets with Symbolic Tree Adaptive Resonance Theory
InformationBiomedical datasets distill many mechanisms of human diseases, linking diseases to genes and phenotypes (signs and symptoms of disease), genetic mutations to altered protein structures, and altered proteins to changes in molecular functions and ...
Sasha Petrenko +7 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Application of Genetic Algorithm Based Intuitionistic Fuzzy k-Mode for Clustering Categorical Data
Cybernetics and Information Technologies, 2017 In present times a great number of clustering algorithms are available which group objects having similar features. But most of the datasets have data values that are categorical, which makes it difficult to implement these algorithms.
Goyal Akarsh +2 more
doaj +1 more source
Categorical variables in developmental research : methods of analysis /
, 1996 This book provides developmental researchers with the basic tools for understanding how to utilize categorical variables in their data analysis. Covering the measurement of individual differences in growth rates, the measurement of stage transitions ...
Eye, Alexander von., Clogg, Clifford C.
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Speaking Stata: Graphing categorical and compositional data
A variety of graphs have been devised for categorical and compositional data, ranging from widely familiar to more unusual displays. Both official Stata commands and user-written programs are available.
Nicholas J. Cox
core
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Clustering Mixed Numeric and Categorical Dataset with Missing Values
, 2018 This dataset is created by the Dataset Generator (http://www.datasetgenerator.com) It is a mix of numeric and categorical attributes. It contains 10,000 records, includes 2 numeric attributes and 4 categorical attributes, the missing ratio is 10%.
Dinh, T (via Mendeley Data) +1 more
core +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source