Results 91 to 100 of about 1,751,067 (274)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

DOUBLE PRINCIPAL COMPONENTS ANALYSIS FOR CATEGORICAL DATA AND ITS APPLICATION TO A MIGRATION STUDY EL DOBLE ANÁLISIS EN COMPONENTES PRINCIPALES PARA DATOS CATEGÓRICOS Y SU APLICACIÓN EN UN ESTUDIO DE MIGRACIÓN

Revista Colombiana de Estadística, 2006
We adapted the double principal component analysis (DACP) (Bouroche 1975), developed for the analysis of three-dimensional quantitative data, to categorical data by mean of the Chi-squared distance between rows and columns profile of a contingency table ...
Pérez Raúl Alberto, Lera Lydia, Boquet Ana   +2 more
doaj  

Break Barriers: Motivation and Obstacles in Secondary School Teacher Education

Education Sciences
The quality of teacher education represents a fundamental pillar for effective educational systems. European and Czech educational policies emphasise alignment with labour market demands and continuous professional development of teachers.
Andrea Hlubučková, Karel Tomšík, Lucie Smékalová, Karel Tomšík, Kateřina Tomšíková   +4 more
doaj   +1 more source

Clustering of categorical variables around latent variables [PDF]

In the framework of clustering, the usual aim is to cluster observations and not variables. However the issue of variable clustering clearly appears for dimension reduction, selection of variables or in some case studies (sensory analysis, biochemistry ...
Jérome SARACCO (GREThA UMR CNRS 5113), Marie CHAVENT (IMB UMR CNRS 5251), Vanessa KUENTZ (IMB UMR CNRS 5251)   +2 more
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

El doble análisis en componentes principales para datos categóricos y su aplicación en un estudio de migración

Revista Colombiana de Estadística, 2006
Se hace una adaptación del método doble análisis en componentes principales (DACP) (Bouroche 1975), creado para el análisis de datos cuantitativos de tipo cúbico, a datos categóricos mediante la utilización de la distancia Chi-cuadrado entre perfiles ...
RAÚL ALBERTO PÉREZ, LYDIA LERA, ANA BOQUET   +2 more
doaj  

Statistical integration in excise supervision: Multinomial logistic regression for detecting risk factors of tobacco factory excise violations

Desimal
Excise tax serves as a fiscal instrument used by the government to control the consumption of goods with negative externalities for society and the environment, such as tobacco and alcoholic beverages.
Boy Riansyah, Nisa Nur Aisyah, Anwar Fitrianto, Aam Alamudi   +3 more
doaj   +1 more source

Participatory Evaluation of Integrated Pest and Soil Fertility Management Options Using Ordered Categorical Data Analysis [PDF]

During participatory rural appraisals, farmers at the Lake Victoria basin of Kenya and Uganda identified Striga, stemborer and declining soil fertility as three major constraints to maize production To reduce food insecurity, several innovative ...
De Groote, Hugo, Kanampiu, Fred, Khan, Zeyaur R., Odhiambo, George D., Rutto, Esther, Vanlauwe, Bernard   +5 more
core   +1 more source