Results 81 to 90 of about 1,751,067 (274)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Determining factors affecting regional poverty levels in Türkiye: a comparison of ordered discrete choice models

Journal of Health, Population and Nutrition
Background This study aims to determine the factors affecting the poverty rate among the households in question by region, the western, central, and eastern regions underwent research separately. Methods This study uses the ordered discrete choice models:
Şeyda Ünver, Ömer Alkan, Ali Kemal Çelik, Hayri Abar   +3 more
doaj   +1 more source

Correspondence analysis and categorical conjoint measurement [PDF]

We show the equivalence between the use of correspondence analysis (CA) of concadenated tables and the application of a particular version of conjoint analysis called categorical conjoint measurement (CCM).
Anna Torres
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Multiple Correspondence Analysis is a Useful Tool to Visualize Complex Categorical Correlated Data

International Journal of Population Data Science, 2017
Objectives We sought to identify the most expensive hospitalized individuals in the Canadian province of Saskatchewan in fiscal year 2012/13, and determine the primary cause of their high use of health services.
Jacqueline Quail, Meric Osman, Gary Teare   +2 more
doaj   +1 more source

Sensitivity and robustness in MDS configurations for mixed-type data: a study of the economic crisis impact on socially vulnerable Spanish people [PDF]

Multidimensional scaling (MDS) techniques are initially proposed to produce pictorial representations of distance, dissimilarity or proximity data. Sensitivity and robustness assessment of multivariate methods is essential if inferences are to be drawn ...
Aurea Grané, Rosario Romera
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

UTILIZING MULTINOMIAL LOGISTIC REGRESSION FOR DETERMINING THE FACTORS INFLUENCING BLOOD PRESSURE

Science Journal of University of Zakho
The aim of this study is to investigate the practical application of the Multinomial (many explanatory variables and many categories) Logistic Regression (MLR) model, which is a fundamental tool for analyzing not only for scale data but also for ...
Azad A. Shareef, Sherzad M. Ajeel, Hussein A. Hashem   +2 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Covariance and PCA for Categorical Variables

, 2007
Covariances from categorical variables are defined using a regular simplex expression for categories. The method follows the variance definition by Gini, and it gives the covariance as a solution of simultaneous equations.
Niitsuma, Hirotaka, Okada, Takashi
core   +1 more source