Results 231 to 240 of about 2,113,180 (319)

Taking a Climate and Health History: A One Health-Informed Approach to Primary Care and Services. [PDF]

Ann Glob Health
Abdoel Wahid F, Lichtveld M, Totoni S, Earle B.   +3 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

How effective are video animations as information tools for patients and the general public? An updated systematic review. [PDF]

Front Digit Health
Moe-Byrne T, Knapp P, Lidster A, Ahamed M, O'Hare H, Golder S, Lister J, Adamson J.   +7 more
europepmc   +1 more source

Social Categories Are Categories

, 2008
Social categories are like any other external category: there are consequences of miscategorizing. The fact that the members of the categories or the consequences are social does not make social categories special, as categories. Nor does the fact that many are conveyed verbally. (So are most other high-level categories.)
openaire   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Recency is sufficient for reconciling categorisation and memory: Commentary on Devraj et al. (2024). [PDF]

Psychon Bull Rev
Hutchinson DR, Little DR, Osth AF.
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Evaluating the impact of deep learning-based image denoising on low-dose CT for lung cancer screening. [PDF]

J Appl Clin Med Phys
Chen SS, Liu HH, Yang CC.
europepmc   +1 more source