Results 161 to 170 of about 95,571 (251)

Positive selection screen identifies natural product β-catenin inactivators

Matthew W. Boudreau, Vítor F. Freire, Sophie C. Corbett, Lucero Martínez-Fructuoso, Shilpa R. Shenoy, Wenyu Yu, Rohitesh Kumar, Christopher C. Thornburg, Rhone K. Akee, Brian D. Peyser, Qinqin Jiang, Jennifer Splaine, Jamie L. Pfaff, Dongli Yu, Benjamin C. Chandler, Dinah M. Abeja, Katherine A. Donovan, Jianwei Che, Benjamin L. Lampson, Mariana Cooke, Marcelo G. Kazanietz, Patricia Szajner, Jennifer A. Smith, Vidyasagar Koduri, Tanja Grkovic, Barry R. O’Keefe, William G. Kaelin   +26 more
openalex   +1 more source

CHD8‐Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs

Advanced Science, EarlyView.
In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Yuanyuan Huang, Zhenhua Hu, Jiali Liao, Lijun Huang, Jinyu Liu, Chen Tu, Yuchen Li, Lulu Xie, Shilei Bi, Xiaobo Fang, Jingsi Chen, Lili Du, Wei Sun, Haibin Wang, Shuang Zhang, Dunjin Chen, Zhaowei Tu   +16 more
wiley   +1 more source

β-Catenin Signaling in Hepatocellular Carcinoma: Mechanisms of Therapeutic Resistance and Emerging Therapeutic Strategies

Anastasia Chambers, Morgan Reeves, Abhishek P Shrestha, Siri Yarrapatni, Sérgio M. Duarte, Ali Zarrinpar   +5 more
openalex   +1 more source

Isocyanate‐Modified Melatplatin(IV) Enhances Antitumor Efficacy via TCF4/COL6A3‐Mediated Extracellular Matrix Remodeling and cGAS‐STING Pathway Activation in Bladder Cancer

Advanced Science, EarlyView.
A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang, Xiaomeng Liu, Tao Zhu, Zirun Su, Ruiping Liu, Zhe Li, Kaixuan Du, Kaipeng Jia, Chong Fu, Yuda Lin, Zihan Xue, Zhe Zhang, Chong Shen, Yunkai Qie, Zhouliang Wu, Zhiheng Liu, Kangkang Liu, Jingyuan Xu, Hailong Hu   +18 more
wiley   +1 more source

VWA2 fuels colon cancer growth and immune evasion through Wnt/β-catenin signaling

Yanlin He, Jiang Chen, Huaqian Dong, Xiuya Ren, Tian Tian, Wei Xie, Tao Yang   +6 more
openalex   +1 more source

Liquid‐Responsive Shape‐Memory Nanofiber‐Reinforced Scaffolds for Cartilage Repair

Advanced Science, EarlyView.
A liquid‐responsive shape‐memory, nanofiber‐reinforced QCG scaffold combines conformal defect filling, an aligned architecture that is structurally permissive for endogenous cell infiltration, and sustained KGN release. This integrated design enhances BMSC viability, migratory activity, and chondrogenic differentiation and promotes hyaline cartilage ...
Jiyang Zeng, Wei Li, Yawei Li, Zhiming Tu, Hong Ma, Yuliang Dai, Zhaoling Ma, Tao Yuan, Bing Wang   +8 more
wiley   +1 more source

Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation

Advanced Science, EarlyView.
Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Jiajia Lu, Yue Xi, Sheng Wang, Ye Chen, Jiajie Yang, Xiaojian Shi   +5 more
wiley   +1 more source

Downstream of β-catenin: A positive feedback loop between Goosecoid and Nodals in Spemann’s organizer

Yagmur Azbazdar, Edward M. De Robertis
openalex   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

CRIF1 promotes aggressive phenotypes and is associated with reduced paclitaxel-induced apoptosis in endometrial cancer cells through Wnt/β-catenin-related signaling [PDF]

Juan Shao, Huanmei Sun, Hu Zhang, Zhanpeng Zhu, Yingchun Duan, Jiashi Gu   +5 more
openalex   +1 more source