Results 151 to 160 of about 9,525 (211)

Conserved early steps of stemmadenine biosynthesis. [PDF]

open access: yesJ Biol Chem
Kamileen MO   +11 more
europepmc   +1 more source

Molecular Pharmacokinetics of Catharanthus (Vinca) Alkaloids

Journal of Clinical Pharmacology, 2007
This review focuses on the published data regarding the molecular determinants (enzymes, transporters, orphan nuclear receptors) of Catharanthus (vinca) alkaloids pharmacokinetics in humans. The clinical impact of these determinants (drug disposition, drug‐drug interactions) is also discussed.
Dominique Levêque
exaly   +3 more sources

Catharanthus Alkaloids XXXII: Isolation of Alkaloids from Catharanthus Trichophyllus Roots and Structure Elucidation of Cathaphylline

Journal of Pharmaceutical Sciences, 1976
Further examination of the cytotoxic alkaloid fractions of Catharanthus trichophyllus roots afforded nine alkaloids. Two of these alkaloids, lochnericine and horhammericine, are responsible for part of the cytotoxic activity. The structure elucidation of cathaphylline, a new beta-anilino acrylate derivative, is described.
Geoffrey A. Cordell   +2 more
exaly   +3 more sources

The Catharanthus Alkaloids:Pharmacognosy and Biotechnology

Current Medicinal Chemistry, 2004
The Catharanthus (or Vinca) alkaloids comprise a group of about 130 terpenoid indole alkaloids. Vinblastine is now marketed for more than 40 years as an anticancer drug and became a true lead compound for drug development. Due to the pharmaceutical importance and the low content in the plant of vinblastine and the related alkaloid vincristine ...
Robert, van Der Heijden   +4 more
openaire   +2 more sources

Imaging MS Analysis in Catharanthus roseus

2022
To understand how the plant regulates metabolism, it is important to determine where metabolites localize in the tissues and cells. Single-cell level omics approaches in plants have shown remarkable development over the last several years, and this data has been instrumental in gene discovery efforts for enzymes and transporters involved in metabolism.
Yamamoto, K.   +3 more
openaire   +3 more sources

Production of anthocyanins by Catharanthus roseus

Fitoterapia, 2003
A stable cell suspension line of Catharanthus roseus producing anthocyanin was obtained. In this strain it was found that approximately 30% of cells regularly accumulated these metabolites and that anthocyanin accumulation occurred between the second half of log phase and the stationary phase of the culture growth cycle.
FILIPPINI, RAFFAELLA   +3 more
openaire   +3 more sources

Catharanthus Alkaloids X. Isolation of Lanceine and Vinosidine from Catharanthus Lanceus Roots

Journal of Pharmaceutical Sciences, 1967
In a continuing search for new biologically active entities in Catharanthus lanceus, additional work on the root (A) fraction has led to the isolation of two alkaloids. One of these, lanceine, was previously isolated from this plant by other workers. Vinosidine, however, although previously reported in a related species, is reported from this species ...
R N, Blomster   +2 more
openaire   +2 more sources

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