Results 1 to 10 of about 9,166 (164)

Vinca Alkaloids

International Journal of Preventive Medicine, 2013
Vinca alkaloids are a subset of drugs obtained from the Madagascar periwinkle plant. They are naturally extracted from the pink periwinkle plant, Catharanthus roseus G. Don and have a hypoglycemic as well as cytotoxic effects.
Maryam Moudi, Rusea Go, Christina Yong Seok Yien, Mohd Nazre   +3 more
doaj   +5 more sources

Cardiovascular safety profile of taxanes and vinca alkaloids: 30 years FDA registry experience [PDF]

Open Heart, 2021
Objective Antimicrotubular agents are among the most commonly used classes of chemotherapeutic agents, but the risk of cardiovascular adverse events (CVAEs) remains unclear.
Avirup Guha, Sarju Ganatra, Brijesh Patel, Daniel Addison, Anita Deswal, Sherry-Ann Brown, Michael Fradley, Akshee Batra, Lauren A Baldassarre, Nihar Desai, Neal Weintraub, Zeeshan Hussain, Vivek Agarwala, Purvish M Parikh, Arjun Ghosh   +14 more
doaj   +2 more sources

TrpA1 activation in peripheral sensory neurons underlies the ionic basis of pain hypersensitivity in response to vinca alkaloids. [PDF]

PLoS ONE, 2017
Chemotherapy induced peripheral neuropathy (CIPN), a side effect of many anti-cancer drugs including the vinca alkaloids, is characterized by a severe pain syndrome that compromises treatment in many patients.
Nina Boiko, Geraldo Medrano, Elizabeth Montano, Nan Jiang, Claire R Williams, Ngonidzashe B Madungwe, Jean C Bopassa, Charles C Kim, Jay Z Parrish, Kenneth M Hargreaves, James D Stockand, Benjamin A Eaton   +11 more
doaj   +2 more sources

Artificial cell vesicle-mediated delivery of Catharanthus roseus (L.) G. Don-derived vinca alkaloids for enhanced antitumor efficacy [PDF]

Frontiers in Bioengineering and Biotechnology
Vinca alkaloids, a class of naturally derived antimitotic agents isolated from Catharanthus roseus, have long been established as potent chemotherapeutic drugs for the treatment of various malignancies.
Xiaodong Zhuang, Liangjiu Huang, Risheng Liu, Liwen Guan, Xingyue Fang, Ting Ma   +5 more
doaj   +2 more sources

Drug fever—an immune-mediated delayed type hypersensitivity reaction to Vinca alkaloids in pediatric oncology patients, possibly mediated by cysteinyl leukotrienes [PDF]

Frontiers in Allergy
BackgroundDrug hypersensitivity reactions are common in pediatric hemato-oncology patients due to multiple factors including immune compromise and pharmacological complexities. Fever can signify severe delayed-type hypersensitivity reactions such as drug
Mona I. Kidon, Mona I. Kidon, Mona I. Kidon, Soad Haj Yahia, Soad Haj Yahia, Soad Haj Yahia, Gadi Abebe-Campino, Gadi Abebe-Campino, Nancy Agmon-Levin, Nancy Agmon-Levin, Nancy Agmon-Levin, Michal Yelon, Michal Yelon   +12 more
doaj   +2 more sources

Evaluation of the Effect of Loratadine versus Diosmin/Hesperidin Combination on Vinca Alkaloids-Induced Neuropathy: A Randomized Controlled Clinical Trial [PDF]

Pharmaceuticals
Neurological injury is a crucial problem that interferes with the therapeutic use of vinca alkaloids as well as the quality of patient life. This study was conducted to assess the impact of using loratadine or diosmin/hesperidin on neuropathy induced by ...
Noha Kamal, Mahmoud S. Abdallah, Essam Abdel Wahed, Nagwa A. Sabri, Sarah Farid Fahmy   +4 more
doaj   +2 more sources

Attempted Synthesis of Vinca Alkaloids Condensed with Three-Membered Rings [PDF]

Molecules, 2018
Our successful work for the synthesis of cyclopropanated vinblastine and its derivatives by the Simmons–Smith reaction was followed to build up further three-membered rings into the 14,15-position of the vindoline part of the dimer alkaloid ...
András Keglevich, Szabolcs Mayer, Réka Pápai, Áron Szigetvári, Zsuzsanna Sánta, Miklós Dékány, Csaba Szántay, Péter Keglevich, László Hazai   +8 more
doaj   +2 more sources

Sensitivity of docetaxel-resistant MCF-7 breast cancer cells to microtubule-destabilizing agents including vinca alkaloids and colchicine-site binding agents. [PDF]

PLoS ONE, 2017
IntroductionOne of the main reasons for disease recurrence in the curative breast cancer treatment setting is the development of drug resistance. Microtubule targeted agents (MTAs) are among the most commonly used drugs for the treatment of breaset ...
Richard C Wang, Xinmei Chen, Amadeo M Parissenti, Anil A Joy, Jack Tuszynski, David N Brindley, Zhixiang Wang   +6 more
doaj   +2 more sources

Supportive care challenges in a resource limited oncology setting: prevalence and management of anthracycline and vinca alkaloid extravasation in Sudan [PDF]

BMC Cancer
Background Chemotherapy extravasation is a serious complication of cancer treatment, particularly with vesicant agents such as anthracyclines and vinca alkaloids. Data from low-resource settings, particularly in Sudan remain limited.
Asmaa Ramadan Alzahman, Yousif B. Hamadalneel, Bashir A. Yousef, Mawahib A. Mustafa, Mohammed H. Alnazeer, Elkhanssa Abdelhameed Ahmed Elhag   +5 more
doaj   +2 more sources

Systemic anti-cancer therapy associated with the occurrence of peripheral neurotoxicity and, specifically, peripheral neuropathy. [PDF]

Int J Cancer
What's new? While the effectiveness of systemic anticancer therapy is well documented, it commonly causes severe toxicity. This study of the 467 systemic anticancer therapy agents currently approved globally for clinical and/or research purposes found that peripheral neurotoxicity is associated with 45% of classical chemotherapies, 21% of targeted ...
Higgins C, Gauthier LR, Smith BH, Colvin L.   +3 more
europepmc   +2 more sources