Results 31 to 40 of about 16,117 (210)

Comparative pathological and cytogenetical study of ethanolic extract of Vinca rosea L. and Vinblastine in treating mammary gland adenocarcinoma implanted mice

open access: yesKufa Journal for Veterinary Medical Sciences, 2011
    Pathological, cytogenetical comparative study was the main objectives of this project between the influence of ethanolic extract of Vinca rosea and Vinblastine (vinca alkaloid) as chemotherapy.
Aoula E. Aqubi   +2 more
doaj   +1 more source

Indole diterpenoid natural products as the inspiration for new synthetic methods and strategies. [PDF]

open access: yes, 2017
Indole terpenoids comprise a large class of natural products with diverse structural topologies and a broad range of biological activities. Accordingly, indole terpenoids have and continue to serve as attractive targets for chemical synthesis.
Corsello, Michael A   +2 more
core   +1 more source

Phytochemical Analysis and In Vitro Antileukemic Activity of Alkaloid-Enriched Extracts from Vinca sardoa (Stearn) Pignatti

open access: yesMolecules, 2023
Vinca sardoa (Stearn) Pignatti, known as Sardinian periwinkle, is widely diffused in Sardinia (Italy). This species contains indole alkaloids, which are known to have a great variety of biological activities.
Daniela De Vita   +14 more
doaj   +1 more source

Bioinformatic Analysis for the Validation of Novel Biomarkers for Cancer Diagnosis and Drug Sensitivity [PDF]

open access: yes, 2015
Background: The genetic control of tumour progression presents the opportunity for bioinformatics and gene expression data to be used as a basis for tumour grading.
Lockwood, Laura Anne Rebecca
core   +2 more sources

Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan

open access: yesNatural Products and Bioprospecting, 2017
Three new pyridine type alkaloids, (−)-vinmajpyridines A–C (1–3), along with two known alkaloids, have been isolated from the aerial parts of Vinca major cultivated in Pakistan.
Xin Wei   +11 more
doaj   +1 more source

Kinesin spindle protein inhibitors in cancer: from high throughput screening to novel therapeutic strategies

open access: yesFuture Science OA, 2022
Bringing to a halt the cell cycle in mitosis and interfering with its normal progression is one of the most successful anti-cancer strategies used nowadays. Classically, several kinds of anti-cancer drugs like taxanes and vinca alkaloids directly inhibit
Rand Shahin, Salah Aljamal
doaj   +1 more source

Comparative study of the hypoglycemic and biochemical effects of Catharanthus roseus (Linn) g. apocynaceae (Madagascar periwinkle) and chlorpropamide (diabenese) on alloxan-induced diabetic rats [PDF]

open access: yes, 2005
The effect of the aqueous extracts of Catharanthus roseus and chlorpropamide (Diabenese) on the levels of serum cholesterol, total protein, lipid peroxidation, blood glucose and liver enzymes were compared in alloxan-induced diabetic rats.
Iweala, E. E. J., Okeke, C. U.
core   +1 more source

Efficacy and Safety of Subcutaneous Efgartigimod PH20 in Adults With Primary Immune Thrombocytopenia (ADVANCE SC): A Multicenter, Randomized, Double‐Blinded, Placebo‐Controlled, Phase 3 Trial

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT Primary autoimmune thrombocytopenia (ITP) is characterized by thrombocytopenia, bleeding, and reduced health‐related quality of life. In the Phase 3 ADVANCE IV study, intravenous efgartigimod induced significant platelet count responses versus placebo in patients with chronic ITP. ADVANCE SC, a Phase 3, multicenter, randomized, double‐blinded,
Nichola Cooper   +546 more
wiley   +1 more source

Modifications on the Basic Skeletons of Vinblastine and Vincristine

open access: yesMolecules, 2012
The synthetic investigation of biologically active natural compounds serves two main purposes: (<em>i</em>) the total synthesis of alkaloids and their analogues; (<em>ii</em>) modification of the structures for producing more ...
Csaba Szántay   +3 more
doaj   +1 more source

Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

open access: yesCancer Cell International, 2022
Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy, along with others, which not only put a tremendous economic effect on ...
Praveen Dhyani   +11 more
doaj   +1 more source

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