Results 31 to 40 of about 83,539 (199)

Vinca minor L. alkaloids and their biological activity (inhibition of human cholinesterases) V. [PDF]

, 2020
Vašíčková A.: Alkaloids of Vinca minor L. and their biological activity (inhibition of human cholinesterases) V. Diploma thesis, Charles University, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Botany, Hradec Králové 2020. From the
Vašíčková, Alžběta
core  

Phytochemical Analysis and In Vitro Antileukemic Activity of Alkaloid-Enriched Extracts from Vinca sardoa (Stearn) Pignatti

Molecules, 2023
Vinca sardoa (Stearn) Pignatti, known as Sardinian periwinkle, is widely diffused in Sardinia (Italy). This species contains indole alkaloids, which are known to have a great variety of biological activities.
Daniela De Vita, Claudio Frezza, Fabio Sciubba, Chiara Toniolo, Camilla Badiali, Rita Petrucci, Martina Bortolami, Paola Di Matteo, Daniele Rocco, Annarita Stringaro, Marisa Colone, Andrea Maxia, Maria Teresa Petrucci, Mauro Serafini, Sebastiano Foddai   +14 more
doaj   +1 more source

Plant‐Derived Natural Product Nanodelivery System in Cancer Therapy

Phytotherapy Research, EarlyView.
This review comprehensively summarizes the recent progress and emerging concepts in nanotechnology‐based delivery systems for plant‐derived natural products, with a particular focus on their application in precision cancer therapy. ABSTRACT Plant‐derived natural products have emerged as important sources of anticancer agents because of their diverse ...
Changqi Shi, LuLu Zhang, Lan Yan, Qi Geng, Li Li, Xiaojuan He, Ning Zhao, Yong Tan, Xiaomeng Zhang, Cheng Lu   +9 more
wiley   +1 more source

Enhanced anti-tumour effects of vinca alkaloids given separately from cytostatic therapies.

, 2013
Background and Purpose In polychemotherapy protocols, that is for treatment of neuroblastoma and Ewing sarcoma, Vinca alkaloids and cell cycle-arresting drugs are usually administered on the same day.
Pfeiffer, S., Jeremias, I., Amtmann, E., Pannert, L., Ehrhardt, H., Wachter, F.   +5 more
core   +1 more source

Modifications on the Basic Skeletons of Vinblastine and Vincristine

Molecules, 2012
The synthetic investigation of biologically active natural compounds serves two main purposes: (<em>i</em>) the total synthesis of alkaloids and their analogues; (<em>ii</em>) modification of the structures for producing more ...
Csaba Szántay, György Kalaus, László Hazai, Péter Keglevich   +3 more
doaj   +1 more source

Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

Cancer Cell International, 2022
Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy, along with others, which not only put a tremendous economic effect on ...
Praveen Dhyani, Cristina Quispe, Eshita Sharma, Amit Bahukhandi, Priyanka Sati, Dharam Chand Attri, Agnieszka Szopa, Javad Sharifi-Rad, Anca Oana Docea, Ileana Mardare, Daniela Calina, William C. Cho   +11 more
doaj   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Kinesin spindle protein inhibitors in cancer: from high throughput screening to novel therapeutic strategies

Future Science OA, 2022
Bringing to a halt the cell cycle in mitosis and interfering with its normal progression is one of the most successful anti-cancer strategies used nowadays. Classically, several kinds of anti-cancer drugs like taxanes and vinca alkaloids directly inhibit
Rand Shahin, Salah Aljamal
doaj   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Fabrication of edge-curled petals-like covalent organic frameworks and their properties for extracting indole alkaloids from complex biological samples

Journal of Pharmaceutical Analysis, 2022
In this study, a functionalized covalent-organic framework (COF) was first synthesized using porphyrin as the fabrication unit and showed an edge-curled, petal-like and well-ordered structure.
Fanrong Sun, Ligai Bai, Mingxue Li, Changqing Yu, Haiyan Liu, Xiaoqiang Qiao, Hongyuan Yan   +6 more
doaj   +1 more source