Results 11 to 20 of about 9,194 (163)

Systemic anti-cancer therapy associated with the occurrence of peripheral neurotoxicity and, specifically, peripheral neuropathy. [PDF]

Int J Cancer
What's new? While the effectiveness of systemic anticancer therapy is well documented, it commonly causes severe toxicity. This study of the 467 systemic anticancer therapy agents currently approved globally for clinical and/or research purposes found that peripheral neurotoxicity is associated with 45% of classical chemotherapies, 21% of targeted ...
Higgins C, Gauthier LR, Smith BH, Colvin L.   +3 more
europepmc   +2 more sources

Vinca alkaloids as a potential cancer therapeutics: recent update and future challenges [PDF]

3 Biotech, 2023
Pradeep Kumar, Tiwari Shubham, Kulshrestha Saurabh   +2 more
exaly   +2 more sources

Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan

Natural Products and Bioprospecting, 2017
Three new pyridine type alkaloids, (−)-vinmajpyridines A–C (1–3), along with two known alkaloids, have been isolated from the aerial parts of Vinca major cultivated in Pakistan.
Afsar Khan, Xu-Dong Zhao, Ya-Ping Liu
exaly   +3 more sources

Negative-Pressure Cavitation Extraction of Four Main Vinca Alkaloids from <em>Catharanthus </em><em>r</em><em>oseus</em> Leaves [PDF]

Molecules, 2012
In the present study, an improved method termed negative-pressure cavitation extraction (NPCE) followed by reverse phase high-performance liquid chromatography (RP-HPLC) was developed for the extraction and quantification of vindoline (VDL ...
Yuangang Zu, Xiaorui Guo, Yujie Fu, Meng Luo, Wei Wang, Liuqing Yang, Fansong Mu   +6 more
doaj   +2 more sources

Cardiotoxic Effects of Yew Tree and Pink Periwinkle Alkaloids

Безопасность и риск фармакотерапии, 2021
Antitumour herbal medicines based on pink periwinkle and yew tree alkaloids are included in combination therapies for many types of cancer. The use of these classes of products may entail cardiotoxic effects leading to life-threatening conditions.
G. S. Mal, E. B. Artyushkova, M. P. Gladchenko, A. A. Ivanova   +3 more
doaj   +1 more source

Larvicidal Effect of Vinca Fruit Extract (Vinca rosea) Against Aedes aegypti Larvae and Secondary Metabolites Profile by Thin Layer Chromatography

Biology, Medicine & Natural Product Chemistry, 2014
Background: Vinca rosea is known contain alkaloids, it was usually used to treat various diseases. Alkaloids from Vinca leaves are also already known have larvicidal activity. Based on this toxicological activity, the fruit of Vinca rosea was selected to
Rahmawati Ekaputri, Sudarsono Sudarsono, Budi Mulyaningsih   +2 more
doaj   +1 more source

P061 (0125) CHEMOTHERAPY-INDUCED POLYNEUROPATHY IN PATIENTS WITH HODGKIN LYMPHOMA TREATED WITH VINCA-ALKALOIDS [PDF]

HemaSphere, 2018
doaj   +2 more sources

Determination of Active Ingredients, Mineral Composition and Antioxidant Properties of Hydroalcoholic Macerates of Vinca minor L. Plant from the Dobrogea Area

Molecules, 2023
In recent decades, new alternative therapies using drugs containing active ingredients of natural origin have been a hot topic for medical research. Based on the confirmed therapeutic potential of the Vinca minor plant, considered in the specialized ...
Ana-Maria Neculai, Gabriela Stanciu, Magdalena Mititelu   +2 more
doaj   +1 more source

Indole Alkaloids from and Growing in Turkey

Natural Product Communications, 2012
A new indole alkaloid, 11-hydroxypolyneuridine, was isolated from Vinca major subsp. major L. and the known indole alkaloids vallesiachotamine and isovallesiachotamine from Vinca minor L.
Fatemeh Bahadori, Gülaçtι Topçu, Mehmet Boǧa, Ayla Türkekul, Ufuk Kolak, Murat Kartal   +5 more
doaj   +1 more source

Biosynthesis and Modulation of Terpenoid Indole Alkaloids in Catharanthus roseus: A Review of Targeting Genes and Secondary Metabolites

Journal of Pure and Applied Microbiology, 2021
The medicinal plant C. roseus synthesizes biologically active alkaloids via the terpenoid indole alkaloid (TIAs) biosynthetic pathway. Most of these alkaloids have high therapeutic value, such as vinblastine and vincristine.
Mukesh Kumar Sharma, Mohan Kumar, Renu
doaj   +1 more source