Journal of Pure and Applied Microbiology, 2021 The medicinal plant C. roseus synthesizes biologically active alkaloids via the terpenoid indole alkaloid (TIAs) biosynthetic pathway. Most of these alkaloids have high therapeutic value, such as vinblastine and vincristine.
Mukesh Kumar Sharma, Mohan Kumar, Renu
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Effect of vinpocetine on retrograde axoplasmic transport [PDF]
, 2007 Många avancerade och komplexa system används idag run-tom i världen och flera av dem är väldigt viktiga att de fungerar och fortsätter göra det. För att inte förstöra dessa system så kan en dry-run användas om någonting behöver uppdateras eller ändras ...
Knyihár-Csillik, Erzsébet +6 more
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M2I-1 disrupts the in vivo interaction between CDC20 and MAD2 and increases the sensitivities of cancer cell lines to anti-mitotic drugs via MCL-1s [PDF]
, 2019 Background Drugs such as taxanes, epothilones, and vinca alkaloids are widely used in the treatment of breast, ovarian, and lung cancers but come with major side effects such as neuropathy and loss of neutrophils and as single agents have a lack of ...
Dang, Nanmao +7 more
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BMC Cancer, 2008 Background Vinca alkaloids are an important class of anticancer agents and semisynthetic vinca alkaloids are developed to improve the therapeutic index of this class of drugs.
Pattyn Greet GO +7 more
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Docking, synthesis and antiproliferative activity of N-acylhydrazone derivatives designed as combretastatin A4 analogues. [PDF]
PLoS ONE, 2014 Cancer is the second most common cause of death in the USA. Among the known classes of anticancer agents, the microtubule-targeted antimitotic drugs are considered to be one of the most important.
Daniel Nascimento do Amaral +11 more
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Repurposing screen identifies mebendazole as a clinical candidate to synergise with docetaxel for prostate cancer treatment [PDF]
, 2020 BACKGROUND: Docetaxel chemotherapy in prostate cancer has a modest impact on survival. To date, efforts to develop combination therapies have not translated into new treatments. We sought to develop a novel therapeutic strategy to tackle chemoresistant
Dufès, Christine +9 more
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RHEOLOGICAL PROPERTIES OF INDOLIC ALKALOIDS OBTAINED FROM NATURAL PRODUCTS [PDF]
Romanian Journal of Petroleum & Gas TechnologyIndole chemistry is a fascinating and complex field. The foul-smelling indole molecule is the building block for various natural and chemical products. Moreover, some indole derivatives are vital pharmaceutical products or essential intermediates. Indole
Ana-Maria Neculai +2 more
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Vincristine in Combination Therapy of Cancer: Emerging Trends in Clinics
Biology, 2021 Treatment of blood malignancies and other cancer diseases has been mostly unfeasible, so far. Therefore, novel treatment regimens should be developed and the currently used ones should be further elaborated. A stable component in various cancer treatment
Jan Škubník +3 more
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Effect of Processing Methods on Nutritive and Antinutritive Properties of Seeds of Brachystegia eurycoma and Detarium microcarpum from Nigeria [PDF]
, 2009 Proximate analysis of the seeds of Brachystegia eurycoma and Detrarium microcarpum were carried out on both the dehulled and undehulled samples of the flour.
Iweala, E. E. J. +3 more
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Chemotherapy-induced peripheral neuropathy in cancer patients : a four-arm randomized trial on the effectiveness of electroacupuncture [PDF]
, 2013 Purpose. Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting side effect of cytostatic drugs. Since there are no proven therapeutic procedures against CIPN, we were interested to define the role of electroacupuncture (EA) from
Bartsch, Hans Helge +5 more
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