Results 21 to 30 of about 9,166 (164)
Docking, synthesis and antiproliferative activity of N-acylhydrazone derivatives designed as combretastatin A4 analogues. [PDF]
PLoS ONE, 2014 Cancer is the second most common cause of death in the USA. Among the known classes of anticancer agents, the microtubule-targeted antimitotic drugs are considered to be one of the most important.
Daniel Nascimento do Amaral +11 more
doaj +1 more source
RHEOLOGICAL PROPERTIES OF INDOLIC ALKALOIDS OBTAINED FROM NATURAL PRODUCTS [PDF]
Romanian Journal of Petroleum & Gas TechnologyIndole chemistry is a fascinating and complex field. The foul-smelling indole molecule is the building block for various natural and chemical products. Moreover, some indole derivatives are vital pharmaceutical products or essential intermediates. Indole
Ana-Maria Neculai +2 more
doaj +1 more source
Vincristine in Combination Therapy of Cancer: Emerging Trends in Clinics
Biology, 2021 Treatment of blood malignancies and other cancer diseases has been mostly unfeasible, so far. Therefore, novel treatment regimens should be developed and the currently used ones should be further elaborated. A stable component in various cancer treatment
Jan Škubník +3 more
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Kufa Journal for Veterinary Medical Sciences, 2011 Pathological, cytogenetical comparative study was the main objectives of this project between the influence of ethanolic extract of Vinca rosea and Vinblastine (vinca alkaloid) as chemotherapy.
Aoula E. Aqubi +2 more
doaj +1 more source
Molecules, 2023 Vinca sardoa (Stearn) Pignatti, known as Sardinian periwinkle, is widely diffused in Sardinia (Italy). This species contains indole alkaloids, which are known to have a great variety of biological activities.
Daniela De Vita +14 more
doaj +1 more source
Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan
Natural Products and Bioprospecting, 2017 Three new pyridine type alkaloids, (−)-vinmajpyridines A–C (1–3), along with two known alkaloids, have been isolated from the aerial parts of Vinca major cultivated in Pakistan.
Xin Wei +11 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum +5 more
wiley +1 more source
Future Science OA, 2022 Bringing to a halt the cell cycle in mitosis and interfering with its normal progression is one of the most successful anti-cancer strategies used nowadays. Classically, several kinds of anti-cancer drugs like taxanes and vinca alkaloids directly inhibit
Rand Shahin, Salah Aljamal
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Vincristine‐induced peripheral neuropathy (VIPN) is a common side effect in children and adolescents treated with vincristine. Assessing VIPN, especially in young children, is challenging due to a lack of sensitive tools. This limits our understanding of the nature and risk factors of VIPN. This study aimed to investigate neurofilament light chain
Peter Erik Lotko Pontoppidan +8 more
wiley +1 more source
Modifications on the Basic Skeletons of Vinblastine and Vincristine
Molecules, 2012 The synthetic investigation of biologically active natural compounds serves two main purposes: (<em>i</em>) the total synthesis of alkaloids and their analogues; (<em>ii</em>) modification of the structures for producing more ...
Csaba Szántay +3 more
doaj +1 more source