Results 41 to 50 of about 16,117 (210)

Fabrication of edge-curled petals-like covalent organic frameworks and their properties for extracting indole alkaloids from complex biological samples

Journal of Pharmaceutical Analysis, 2022
In this study, a functionalized covalent-organic framework (COF) was first synthesized using porphyrin as the fabrication unit and showed an edge-curled, petal-like and well-ordered structure.
Fanrong Sun, Ligai Bai, Mingxue Li, Changqing Yu, Haiyan Liu, Xiaoqiang Qiao, Hongyuan Yan   +6 more
doaj   +1 more source

The Effect of Vincristine Sulphate on the Axoplasmic Flow of Proteins in Cultured Sympathetic Neurons [PDF]

, 1973
The effect of vincristine sulphate on the axoplasmic flow of labelled proteins in neurites of chick embryo sympathetic neurons growing in tissue culture was studied by autoradiography.
England, J. M., Goldstein, M. N., Kadin, M. E.   +2 more
core  

Isoform Specificity of a Compound Targeting Actin Filaments Containing Tropomyosin Tpm1.8/1.9

Cytoskeleton, EarlyView.
ABSTRACT The unbranched actin filaments in mammalian cells are usually composed of co‐polymers of a specific tropomyosin isoform with actin. Genetic manipulation has revealed that the tropomyosins largely define the functional properties of actin filaments in an isoform‐specific, non‐redundant manner.
Jeff Hook, Edna C. Hardeman, Peter W. Gunning   +2 more
wiley   +1 more source

Monomer indolalkaloidok és rokonvegyületeik szintézise = Synthesis of monomer indole alkaloids and related compounds [PDF]

, 2009
"A": Új biomimetikus szintézisutat dolgoztunk ki az ibofillidinváz felépítésére. Megvalósítottuk három alkaloid új, konvergens szintézisét, valamint további három alkaloidnak az első szintézisét.
Kalaus, György, Léder, László, Tóth, Flórián, Ujvári, Viktor   +3 more
core  

Design and Synthesis of Lactose‐Derived Ligands and Their Application in Asymmetric Friedel–Crafts Alkylation

European Journal of Organic Chemistry, EarlyView.
This work describes the synthesis of lactose‐ and glucose‐derived chiral ligands and their application in the catalytic enantioselective Friedel–Crafts alkylation of indole with a series of trans‐β‐nitrostyrenes. The optimal ligand was an acetate protected, lactose‐derived pyridyl imine and its zinc complex afforded ees up to 93% and yields up to 93 ...
Sandra Bulawa, Julia Bruno‐Colmenarez, Patrick J. Guiry   +2 more
wiley   +1 more source

Growth light substantially affects both primary and secondary metabolic processes in Catharanthus roseus plants

Photosynthetica, 2023
Common periwinkle (Catharanthus roseus L.) is an important medicinal plant used by the pharmaceutical industry. The present work aimed to determine the effect of low light intensity on the primary and secondary metabolic processes, using various ...
F. GHOLIZADEH, É. DARKÓ, K. BENCZÚR, K.Á. HAMOW, M. DERNOVICS, K. NAGY, T. JANDA, M.R. RADY, G. GOHARI, M. PÁL, V.N. LE, G. SZALAI   +11 more
doaj   +1 more source

Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys [PDF]

, 2011
Croton macrobothrys Baill, Euphorbiaceae, is a tree from the Atlantic Forest in Southern Brazil, used in traditional medicine and popularly known as "dragon's blood" and "pau-sangue".
CARVALHO, João E. de, CORDEIRO, Inês, DUARTE-ALMEIDA, Joaquim M., FURLAN, Cláudia M., MOTTA, Lucimar B., NEGRI, Giuseppina, RUIZ, Ana Lúcia T. G., SALATINO, Antonio, SALATINO, Maria L. F., Santos, Deborah Yara Alves Cursino dos   +9 more
core   +3 more sources

Antioxidant and Cytotoxic Properties of Piper spp. Volatile Oils That Inhibit Pathogenic Microorganisms

Flavour and Fragrance Journal, EarlyView.
The samples were fungicidal against Candida, with MICs ranging from 62.5 to 250 μg/mL, and fungistatic against Penicillium adametzii, Aspergillus flavus and A. niger, with MICs of 1000 μg/mL. The volatile oils of Piper aduncum and Piper marginatum reduced the viability of MDA‐MB231 cells.
Midiã R. Oliveira, Ely D. Alfaia Neto, Carlos Eduardo C. Alves, Renata Galvão de Azevedo, Alice F. Gomes, Flávia Juliana Reis de Sousa, Juan Campos de Oliveira, Larissa Raquel S. Maciel, Gemilson S. Pontes, Ari F. Hidalgo, Antonia Q. L. Souza, Rita C. Saraiva Nunomura   +11 more
wiley   +1 more source

Report on Vincristine-Producing Endophytic Fungus Nigrospora zimmermanii from Leaves of Catharanthus roseus

Metabolites, 2022
Vincristine is an anti-cancer compound and one of the most crucial vinca alkaloids produced by the medicinal plant Catharanthus roseus (L.) G. Don. (Apocynaceae). This plant is home to hundreds of endophytic microbes, which produce a variety of bioactive
Kanchan Birat, Reem Binsuwaidan, Tariq Omar Siddiqi, Showkat Rasool Mir, Nawaf Alshammari, Mohd Adnan, Rahila Nazir, Bushra Ejaz, Moien Qadir Malik, Rikeshwer Prasad Dewangan, Syed Amir Ashraf, Bibhu Prasad Panda   +11 more
doaj   +1 more source

Systemic anti‐cancer therapy associated with the occurrence of peripheral neurotoxicity and, specifically, peripheral neuropathy

International Journal of Cancer, EarlyView.
What's New? While the effectiveness of systemic anticancer therapy is well documented, it commonly causes severe toxicity. This study of the 467 systemic anticancer therapy agents currently approved globally for clinical and/or research purposes found that peripheral neurotoxicity is associated with 45% of classical chemotherapies, 21% of targeted ...
Cassie Higgins, Lynn R. Gauthier, Blair H. Smith, Lesley Colvin   +3 more
wiley   +1 more source