Results 41 to 50 of about 9,166 (164)

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

open access: yesThe FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti   +3 more
wiley   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise   +2 more
wiley   +1 more source

Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of Indole Alkaloids Isolated from Catharanthus roseus (L.) G. Don Cultivated Conventionally and Derived from In vitro Cultures

open access: yesNotulae Botanicae Horti Agrobotanici Cluj-Napoca, 2016
Catharanthus roseus (periwinkle) is a medicinal plant commonly known for its wide biological activity. In many countries different parts of this plant are used for the treatment of diabetes, hypertension and for menstrual regulation.
Aneta WESOŁOWSKA   +3 more
doaj   +1 more source

Protective effects of Vinca herbaceous extract against scopolamine-induced behavioral disturbances and brain oxidative stress in rats

open access: yesHeliyon, 2022
Ethnopharmacological relevance: Alzheimer's disease (AD) as the most common type of dementia, is affecting the life of many senior individuals around the world. Vinca herbacea Waldst. & Kit. (V.
Mir-Jamal Hosseini   +5 more
doaj   +1 more source

Efficacy and Safety of Subcutaneous Efgartigimod PH20 in Adults With Primary Immune Thrombocytopenia (ADVANCE SC): A Multicenter, Randomized, Double‐Blinded, Placebo‐Controlled, Phase 3 Trial

open access: yesAmerican Journal of Hematology, Volume 101, Issue 7, Page 1494-1506, July 2026.
ABSTRACT Primary autoimmune thrombocytopenia (ITP) is characterized by thrombocytopenia, bleeding, and reduced health‐related quality of life. In the Phase 3 ADVANCE IV study, intravenous efgartigimod induced significant platelet count responses versus placebo in patients with chronic ITP. ADVANCE SC, a Phase 3, multicenter, randomized, double‐blinded,
Nichola Cooper   +546 more
wiley   +1 more source

"AN IN VITRO INVESTIGATION ON THE INHIBITORY EFFECTS OF FOUR DIFFERENT SPECIES OF VINCA EXTRACTS ON LEISHMANIA MAJOR "

open access: yesIranian Journal of Public Health, 1997
Vinca minor, Vinca major, Vinca variegata and Vinca rosea are different species of Vinca genus, of Apocynaceae family. In addition to ornamental applications, they are placed in the group of medicinal plants , because of the various alkaloids they ...
M.Assmar   +8 more
doaj  

Antioxidant and Cytotoxic Properties of Piper spp. Volatile Oils That Inhibit Pathogenic Microorganisms

open access: yesFlavour and Fragrance Journal, Volume 41, Issue 4, Page 935-942, July 2026.
The samples were fungicidal against Candida, with MICs ranging from 62.5 to 250 μg/mL, and fungistatic against Penicillium adametzii, Aspergillus flavus and A. niger, with MICs of 1000 μg/mL. The volatile oils of Piper aduncum and Piper marginatum reduced the viability of MDA‐MB231 cells.
Midiã R. Oliveira   +11 more
wiley   +1 more source

In Vitro Antineoplastic Effects of Zataria multiflora: A Systematic Review of Mechanisms, Selectivity, and Synergy

open access: yesFood Science &Nutrition, Volume 14, Issue 7, July 2026.
Zataria multiflora (ZM) is an aromatic plant containing various bioactive components, including phenolic compounds, flavonoids, and terpenoids. Here, we systematically review 27 articles to explore the effect of ZM on different cancer/normal cell lines.
Alireza Khanahmad   +6 more
wiley   +1 more source

Pharmacological significance of Catharanthus roseus in cancer management: A review

open access: yesPharmacological Research - Modern Chinese Medicine
Introduction: Catharanthus roseus, commonly known as Vinca Rosea or Madagascar periwinkle, is a significant plant species within the Apocynaceae family, known for its diverse medicinal properties and ornamental attributes, long embraced by Chinese ...
Siddharth Goswami   +3 more
doaj   +1 more source

Mediastinal Lymphoma in 70 Dogs Treated With Lomustine or Anthracycline‐Based Multi‐Agent Chemotherapy

open access: yesVeterinary and Comparative Oncology, Volume 24, Issue 2, Page 382-392, June 2026.
ABSTRACT Primary mediastinal lymphoma is rare in dogs and literature exploring this disease is limited. Therefore, the aim of this study was to describe presentation, treatment and outcome in a large cohort of dogs with mediastinal lymphoma and explore prognostic factors including chemotherapy protocol. This retrospective multi‐institute study included
Diogo Machado   +11 more
wiley   +1 more source

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