Results 41 to 50 of about 83,539 (199)

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source

Survival outcomes in dogs treated with vinorelbine‐based adjuvant treatment following surgical resection of grade II and III pulmonary carcinoma

Journal of Small Animal Practice, EarlyView.
Objectives Pulmonary carcinoma in dogs is commonly managed with surgical resection; however, the role of adjuvant chemotherapy for grade II and III carcinomas remains unclear. This retrospective multicentre study investigated the outcomes in dogs treated with vinorelbine‐based adjuvant treatment (as monotherapy or combined chemotherapy) following ...
N. Wong, L. Brockley, S. Rajan, J. Yu
wiley   +1 more source

Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae) [PDF]

, 2013
BACKGROUND: Malaria, trypanosomiasis and leishmaniasis have an overwhelming impact in the poorest countries in the world due to their prevalence, virulence and drug resistance ability.
Swaleh, S. M., Hassanali, Ahmed, Ndiege, Isaiah O, Brun, R., Dalsgaard, Petur, Ahmed Hassanali, Ndiege, I. O., Malebo, Hamisi M, Monical Cal, Petur Dalsgaard, Maurice O Omolo, Hassanali, A., Wenzler, T., Sequin, U., Hamburger, M., Wenzler, Tanja, Tanja Wenzler, Omolo, M. O., Omolo, Maurice O, Hamisi M Malebo, Dalsgaard, P., Cal, M., Häussinger, Daniel, Daniel Häussinger, Häussinger, D., Hamburger, Matthias, Brun, Reto, Sauda M Swaleh, Malebo, H. M., Séquin, Urs, Isaiah O Ndiege, Reto Brun, Cal, Monical, Swaleh, Sauda M, Urs Séquin, Matthias Hamburger   +35 more
core   +2 more sources

Report on Vincristine-Producing Endophytic Fungus Nigrospora zimmermanii from Leaves of Catharanthus roseus

Metabolites, 2022
Vincristine is an anti-cancer compound and one of the most crucial vinca alkaloids produced by the medicinal plant Catharanthus roseus (L.) G. Don. (Apocynaceae). This plant is home to hundreds of endophytic microbes, which produce a variety of bioactive
Kanchan Birat, Reem Binsuwaidan, Tariq Omar Siddiqi, Showkat Rasool Mir, Nawaf Alshammari, Mohd Adnan, Rahila Nazir, Bushra Ejaz, Moien Qadir Malik, Rikeshwer Prasad Dewangan, Syed Amir Ashraf, Bibhu Prasad Panda   +11 more
doaj   +1 more source

Management of Eprinomectin Neurotoxicosis in Cats

Journal of Veterinary Emergency and Critical Care, EarlyView.
ABSTRACT Objective To provide a resource for managing eprinomectin neurotoxicosis in cats, emphasizing the unique aspects of this particular macrocyclic lactone. Etiology The label dose of eprinomectin‐containing parasiticides causes neurotoxicosis in P‐glycoprotein–deficient cats.
Katrina L. Mealey, Linda G. Martin, Victoria P. Kastenholz   +2 more
wiley   +1 more source

THE ANTIMICROBIAL EFFECT OF GENUS VINCA ON SOME PATHOGEN MICROORGANISM

Iranian Journal of Public Health, 1995
Vinca major, minor and rosea are three species of vinca genus and Apocynaceae family. The present work is to investigate antimicrobial effects of these plants against Candida albicans, Pseudomonas aeroginosa and Staphylococus aureus.
S.Mehrab, A. Majd, T. Tamadon   +2 more
doaj  

Growth light substantially affects both primary and secondary metabolic processes in Catharanthus roseus plants

Photosynthetica, 2023
Common periwinkle (Catharanthus roseus L.) is an important medicinal plant used by the pharmaceutical industry. The present work aimed to determine the effect of low light intensity on the primary and secondary metabolic processes, using various ...
F. GHOLIZADEH, É. DARKÓ, K. BENCZÚR, K.Á. HAMOW, M. DERNOVICS, K. NAGY, T. JANDA, M.R. RADY, G. GOHARI, M. PÁL, V.N. LE, G. SZALAI   +11 more
doaj   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

One-Pot Synthesis of Vinca Alkaloids–Phomopsin Hybrids

, 2016
Hybrids of vinca alkaloids and phomopsin A have been elaborated with the aim of interfering with the “vinca site” and the “peptide site” of the vinca domain in tubulin.
María Concepción García Alvarez (1786645), Françoise Guéritte (1786639), Olga Gherbovet (1786642), Fanny Roussi (1502851), Federico Gago (60533), Sylviane Thoret (475087), Claire Coderch (1786636), Jérôme Bignon (1574956)   +7 more
core   +1 more source

Serial growth plate monitoring in a 3‐month‐old Labrador retriever receiving vinblastine chemotherapy

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract A 3‐month‐old, male, entire Labrador retriever was presented for evaluation of a congenital mast cell tumour of the right pinna. Pinnectomy and regional lymphadenectomy confirmed a high‐grade mast cell tumour with nodal pre‐metastasis. Eight vinblastine chemotherapy treatments were administered over 12 weeks.
Paige A. A. Brown, Kate M. Sippel, Alison Masyr   +2 more
wiley   +1 more source