Results 61 to 70 of about 83,539 (199)

Cytoskeletal Dynamics in Cancer: From Pathogenesis to Treatment

MedComm, Volume 7, Issue 10, October 2026.
This review systematically addresses the fundamental roles of the cytoskeleton (actin filaments, microtubules, and intermediate filaments) in cancer progression. We focus on how cytoskeletal dynamics regulate tumor proliferation, metastasis, and programmed cell death, while also modulating the immune microenvironment. Understanding these mechanisms may
Jie Chen, Wenxi Yang, Yonghan Song, Yuanhao Zhang, Jia Ma, Tingyao Wang, Jijun Zheng, Hebin Zhang, Yiyao Liu, Jinhao Zeng   +9 more
wiley   +1 more source

The Role of the Antidepressants in Managing Chemotherapy‐Induced Neuropathic Pain: A Systematic Review

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
From symptom relief to multimodal care: duloxetine and amitriptyline may reduce established CIPN‐related pain and provide a therapeutic foundation for future combination strategies. ABSTRACT Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and debilitating complication of cancer treatment, characterized by neuropathic pain, sensory ...
Rosamaria Caminiti, Valeria Mazza, Saverio Nucera, Francesca Oppedisano, Lucia Carmela Passacatini, Jessica Maiuolo, Valentina Malafoglia, Alessandro Giorgio, Andrea Soluri, Claudia Pileggi, Carlo Tomino, Vincenzo Mollace, Sara Ilari, Carolina Muscoli   +13 more
wiley   +1 more source

Vinca minor L. alkaloids and their biological activity II.

, 2021
Pavuková, S.:Vinca minor L. alkaloids and their biological activity II. Diploma thesis, Charles University, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Botany, Hradec Králové 2020. Vinca minor L.
Pavuková, Simona
core  

Pharmacological significance of Catharanthus roseus in cancer management: A review

Pharmacological Research - Modern Chinese Medicine
Introduction: Catharanthus roseus, commonly known as Vinca Rosea or Madagascar periwinkle, is a significant plant species within the Apocynaceae family, known for its diverse medicinal properties and ornamental attributes, long embraced by Chinese ...
Siddharth Goswami, Amena Ali, Madhulika Esther Prasad, Pallavi Singh   +3 more
doaj   +1 more source

Sequence Inversion Dictates the Antiproliferative Activity of Bidirectional Tryptophan‐Containing Dipeptide Libraries

Journal of Peptide Science, Volume 32, Issue 10, October 2026.
Reversing the peptide backbone sequence of novel tryptophyl‐dipeptides uncovers profound changes in synthetic accessibility and antineoplastic profiles against human solid tumors. Phenotypic screening identifies a conformationally restricted lead architecture that achieves sub‐micromolar growth inhibition, confirming sequence topology as a critical ...
J. Benamer Díaz, Adam N. Khan, Aday González‐Bakker, José M. Padrón   +3 more
wiley   +1 more source

Dutch survey pyrrolizidine alkaloids in animal forage [PDF]

, 2009
Pyrrolizidine alkaloids (PAs) are secondary plant metabolites produced by a number of plants from the Asteraceae (Compositae), Boriginaceae and Fabaceae (Leguminosae) families.
Jong, J., de, de Jong, J., Oosterink, J.E., Beumer, B., Mulder, P.P.J.   +4 more
core  

Model of the molecular mechanism of stathmin interplay with Vinca alkaloids and taxanes.

, 2015
Left side of the cartoon depicts a situation in which the level of expression is normal, i.e. not higher in the tumor that in the surrounding cells: stabilizing effect of paclitaxel and destabilizing effect of Vinca alkaloids, while right side depicts a ...
Vincent Peyrot (94785), Philipp O. Tsvetkov (196284), François Devred (747656), Soazig Malesinski (747655), Anna Kruczynski (333895)   +4 more
core   +1 more source

HURP binding to the vinca domain of β-tubulin accounts for cancer drug resistance

Nature Communications
Vinca alkaloids, a class of tubulin-binding agent, are widely used in treating cancer, yet the emerging resistance compromises their efficacy. Hepatoma up-regulated protein (HURP), a microtubule-associated protein displaying heightened expression across ...
Athira Saju, Po-Pang Chen, Tzu-Han Weng, Su-Yi Tsai, Akihiro Tanaka, Yu-Ting Tseng, Chih-Chia Chang, Chun-Hsiung Wang, Yuta Shimamoto, Kuo-Chiang Hsia   +9 more
doaj   +1 more source

The First Global Report on the Alkaloid Aspidospermidine in Vinca herbacea: A Potential Source of Anticancer Alkaloid Precursors

Future Natural Products
Vinca herbacea Waldst. & Kit., a rare perennial species of the Apocynaceae family, is distributed across temperate regions of Western Asia and Eastern Europe. However, its presence in Iran is restricted to a few recorded sites.
Mohammad Kordkatouli, Aryan Sateei
doaj   +1 more source

Mitotic Block of Human Blood Cells by Vinca herbacea, Catharanthus roseus and Colchicine Alkaloids [PDF]

Journal of Medicinal Plants and By-products, 2018
Catharanthus roseus (L.) G.Don is a plant which produces anticancer and anti-mitotic indole alkaloids. Colchicine is an anti-mitotic drug. Anti-mitotic effects of Vinca herbacea Waldst. & Kit. indole alkaloids is unknown.
Babak Delnavaz Hashemloian, Azra Ataei Azimi   +1 more
doaj