Results 71 to 80 of about 16,117 (210)

Cell cycle checkpoint in cancer: a therapeutically targetable double-edged sword [PDF]

, 2016
Major currently used anticancer therapeutics either directly damage DNA or target and upset basic cell division mechanisms like DNA replication and chromosome segregation.
DELLA MONICA, ROSA, GRIECO, DOMENICO, Visconti, Roberta   +2 more
core   +1 more source

Second Line Treatment Decision as Per Standard of Care or Foundation Medicine in Patients With Locally Advanced or Metastatic Non‐Small Cell Lung Cancer

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Background Molecular genetic profiling is crucial for treatment choice in patients with advanced non‐small cell lung cancer (NSCLC). The Lung‐ONE study aimed to determine the clinical utility of comprehensive genomic profile (CGP) tests, such as FoundationOne CDx or FoundationOne Liquid, in guiding second line therapy decisions for advanced ...
Federico Rojo, Enriqueta Felip, Oscar Juan Vidal, Rosario García Campelo, David Aguiar Bujanda, Josefa Terrasa Pons, Rafael López‐Castro, Antonio Calles, Alfredo Paredes Lario, Reyes Bernabé Caro, Isidoro Barneto Aranda, Luis García‐Palacios, Javier De Castro Carpeño   +12 more
wiley   +1 more source

DNA Binding Studies of Vinca Alkaloids: Experimental and Computational Evidence

Natural Product Communications, 2012
Fluorescence studies on the indole alkaloids vinblastine sulfate, vincristine sulfate, vincamine and catharanthine have demonstrated the DNA binding ability of these molecules.
Prateek Pandya, Surendra P. Gupta, Kumud Pandav, Ritu Barthwal, B. Jayaram, Surat Kumar   +5 more
doaj   +1 more source

Magnetic resonance imaging patterns of tumor response to chemotherapy in desmoid‐type fibromatosis

Cancer Medicine, 2021
Background We aimed to investigate changes in volume and MRI T2‐weighted intensity in desmoid‐type fibromatosis (DF) receiving methotrexate plus vinca‐alkaloids (MTX‐VA) at Istituto Nazionale dei Tumori, Milan.
Edoardo Zanchetta, Chiara Maura Ciniselli, Annalisa Bardelli, Chiara Colombo, Silvia Stacchiotti, Giacomo Giulio Baldi, Salvatore Provenzano, Rossella Bertulli, Federica Bini, Alessandra Casale, Francesca Gabriella Greco, Andrea Ferrari, Paolo Verderio, Marco Fiore, Alessandro Gronchi, Paolo Giovanni Casali, Carlo Morosi, Elena Palassini   +17 more
doaj   +1 more source

Mechanism of Gzma‐mediated GEF‐H1 activation in intestinal epithelial cells leading to intestinal barrier dysfunction in sepsis

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
Abstract Background Sepsis‐induced intestinal injury is a severe complication associated with dysfunction affecting multiple organ systems and a significantly elevated risk of death. Intestinal barrier dysfunction plays a central role, but the underlying molecular pathways remain incompletely understood. The present study sought to explore how the Gzma/
Zexing Lin, Haiyang Jiang, Chujun Ni, Liting Deng, Huan Yang, Runnan Wang, Peizhao Liu, Xuanheng Li, Yilong Yu, Weijie Li, Bo Liao, Juanhan Liu, Weizhen Li, Jiaxin Yang, Yue Chao, Haiqing Liu, Xiuwen Wu, Jianan Ren, Yun Zhao   +18 more
wiley   +1 more source

HURP binding to the vinca domain of β-tubulin accounts for cancer drug resistance

Nature Communications
Vinca alkaloids, a class of tubulin-binding agent, are widely used in treating cancer, yet the emerging resistance compromises their efficacy. Hepatoma up-regulated protein (HURP), a microtubule-associated protein displaying heightened expression across ...
Athira Saju, Po-Pang Chen, Tzu-Han Weng, Su-Yi Tsai, Akihiro Tanaka, Yu-Ting Tseng, Chih-Chia Chang, Chun-Hsiung Wang, Yuta Shimamoto, Kuo-Chiang Hsia   +9 more
doaj   +1 more source

The First Global Report on the Alkaloid Aspidospermidine in Vinca herbacea: A Potential Source of Anticancer Alkaloid Precursors

Future Natural Products
Vinca herbacea Waldst. & Kit., a rare perennial species of the Apocynaceae family, is distributed across temperate regions of Western Asia and Eastern Europe. However, its presence in Iran is restricted to a few recorded sites.
Mohammad Kordkatouli, Aryan Sateei
doaj   +1 more source

Mitotic Block of Human Blood Cells by Vinca herbacea, Catharanthus roseus and Colchicine Alkaloids [PDF]

Journal of Medicinal Plants and By-products, 2018
Catharanthus roseus (L.) G.Don is a plant which produces anticancer and anti-mitotic indole alkaloids. Colchicine is an anti-mitotic drug. Anti-mitotic effects of Vinca herbacea Waldst. & Kit. indole alkaloids is unknown.
Babak Delnavaz Hashemloian, Azra Ataei Azimi   +1 more
doaj  

Cancer Neuroscience: Innovative Conception and Emerging Strategy of Therapy

MedComm, Volume 7, Issue 4, April 2026.
In this review, we summarize nerve–cancer interactions and conclude two additional interactions, “perineural invasion” and “neuro‐microbic‐oncology.” Emphasizing the important role of nerves in tumor progression. The nervous system also contributes to the development of cancer comorbidities such as cancer depression and cognitive dysfunction.
Ting Wang, Zikai Dong, Yongfei Wang, Ziyi An, Siyuan Wang, Wei‐Lin Jin   +5 more
wiley   +1 more source

Involvement of cannabinoid signaling in vincristine-induced gastrointestinal dysmotility in the rat [PDF]

, 2017
[Background]: In different models of paralytic ileus, cannabinoid receptors are overexpressed and endogenous cannabinoids are massively released, contributing to gastrointestinal dysmotility.
Abalo, Raquel, Girón, Rocío, López-Pérez, Ana E., Martín, M. Isabel, Uranga-Ocio, José Antonio, Vera, Gema   +5 more
core   +1 more source