Cytostatic and Non-Apoptotic Effects of Vinorelbine-Based Therapy in 3D Endometrial Cancer Spheroids [PDF]
BiologyResistance to apoptosis represents a major therapeutic challenge in advanced and recurrent endometrial cancer. This study investigated whether vinorelbine, alone or in combination with lithium chloride (LiCl) or medroxyprogesterone acetate (MPA ...
Berna Yıldırım +3 more
doaj +2 more sources
Vinorelbine With or Without Thiotepa for HER2‐Negative Metastatic Breast Cancer: A Propensity Score Analysis [PDF]
Cancer MedicineBackground Vinorelbine is commonly used to treat metastatic breast cancer (mBC), while thiotepa is known for its ability to cross the blood–brain barrier.
Aurelia Robert +15 more
doaj +2 more sources
Symptomatic and pathological features in chemical phlebitis rat model by injection vinorelbine via dorsal pedal vein [PDF]
Scientific ReportsIntravenous administration of vesicants or irritants frequently leads to chemical phlebitis. We aimed to establish a chemical phlebitis rat model by injection vinorelbine via dorsal pedal vein and evaluate the general symptoms as well as the pathological
Haijie Ji +10 more
doaj +2 more sources
EClinicalMedicine, 2022 Summary: Background: Currently, there is no US Food and Drug Administration approved therapy for patients with pleural mesothelioma who have relapsed following platinum-doublet based chemotherapy. Vinorelbine has demonstrated useful clinical activity in
Sarah Danson +2 more
exaly +3 more sources
Identification of YAP regulators through high-throughput screening and NanoBiT-based validation-drug repositioning for cancer therapy [PDF]
Animal Cells and SystemsYes-associated protein (YAP), a key co-transcription factor of the Hippo pathway, is a promising drug target for cancer therapy due to its critical role in promoting cell proliferation, survival, and tumor progression when dysregulated.
Ji-Youn Lim +6 more
doaj +2 more sources
A Case Report of Advanced Pulmonary Adenocarcinoma in a Dog Managed with Chemotherapy and Cytokine-Based Immunotherapy [PDF]
AnimalsPulmonary adenocarcinoma in dogs, particularly in advanced stages, carries a poor prognosis with limited therapeutic options. Immunotherapeutic approaches that activate natural killer (NK) cells may provide additional clinical benefit.
Kyu-Duk Yeon, Ji-Hyuk Seo, Jung-Hyun Kim
doaj +2 more sources
Case Report of Acute Severe Hyponatremia Induced by Desmopressin Administration During Chemotherapy [PDF]
Clinical Case ReportsPatients undergoing chemotherapy are prone to developing hyponatremia due to insufficient oral intake because of nausea and vomiting, administration of large volumes of intravenous fluids, syndrome of inappropriate antidiuretic hormone secretion induced ...
Koutaro Ono +6 more
doaj +2 more sources
npj Breast Cancer, 2022 While therapies such as chemotherapy combined with immunotherapy, sacituzumab govitecan, and PARP inhibitors are available for metastatic TNBC, on disease progression after these therapies, the mainstay of therapy is chemotherapy.
Dou-Dou Li +6 more
doaj +1 more source
Phase I Study of Oral Vinorelbine in Combination with Erlotinib in Advanced Non-Small Cell Lung Cancer (NSCLC) Using Two Different Schedules. [PDF]
PLoS ONE, 2016 PURPOSE:This study aimed to evaluate the safety, tolerability and pharmacokinetics of the combination of oral vinorelbine with erlotinib using the conventional (CSV) and metronomic (MSV) dosing schedules in patients with advanced non-small cell lung ...
Natalia Sutiman +8 more
doaj +1 more source
Cells, 2023 Metastasis, rather than the growth of the primary tumor, accounts for approximately 90% of breast cancer patient deaths. Microtentacles (McTNs) formation represents an important mechanism of metastasis.
Vasileios Vardas +8 more
doaj +1 more source