Results 11 to 20 of about 15,255 (159)

Active symptom control with or without oral vinorelbine in patients with relapsed malignant pleural mesothelioma (VIM): A randomised, phase 2 trial

EClinicalMedicine, 2022
Summary: Background: Currently, there is no US Food and Drug Administration approved therapy for patients with pleural mesothelioma who have relapsed following platinum-doublet based chemotherapy. Vinorelbine has demonstrated useful clinical activity in
Dean A. Fennell, Catharine Porter, Jason Lester, Sarah Danson, Paul Taylor, Michael Sheaff, Robin M Rudd, Aarti Gaba, Sara Busacca, Lisette Nixon, Georgina Gardner, Liz Darlison, Charlotte Poile, Cathy Richards, Peter-Wells Jordan, Gareth Griffiths, Angela Casbard   +16 more
doaj   +3 more sources

Hypertrophic Osteopathy Associated With Primary Pulmonary Histiocytic Sarcoma in a Dog. [PDF]

Vet Med Sci
ABSTRACT Hypertrophic osteopathy (HO) is a paraneoplastic or parainflammatory syndrome characterised by painful periosteal new bone formation and soft tissue swelling, most commonly associated with thoracic neoplasia. The pathogenesis of HO remains incompletely understood and may involve neurovascular mechanisms, altered pulmonary filtration of ...
Rinaldi V, Ridolfi F, Finotello R, Rosto M, Luciani A, Boari A, Crisi PE.   +6 more
europepmc   +2 more sources

Unveiling Candidate Markers for Drug Resistance or Synthetic Lethality in Cervical Cancer: Integrative Analysis of Genetic and Pharmacoprofiling. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Introduction Systemic cervical cancer management continues to be challenging. Numerous chemotherapies have been approved, but predicting response is difficult due to the lack of biomarkers. Here, we analyze the genetic and protein profiles of 20 cervical cancer cell lines (CCCLs) and explore their correlation with drug response patterns to ...
Scholl S, Nery ED, Gestraud P, Halladjian M, Girard E, Soria A, Anthony E, De Koning L, Servant N, Berns E, Kamal M.   +10 more
europepmc   +2 more sources

Efficacy and safety of inetetamab-containing regimens in patients with HER2-positive metastatic breast cancer: a real-world retrospective study in China

Frontiers in Oncology, 2023
BackgroundInetetamab (cipterbin) is an innovative anti-HER2 humanized monoclonal antibody. The efficacy and safety of a combination of inetetamab and vinorelbine in the first-line treatment of human epidermal receptor positive (HER2+) metastatic breast ...
Xiaoyu Liu, Peng Zhang, Chao Li, Xiang Song, Xiang Song, Zhaoyun Liu, Wenna Shao, Sumei Li, Xinzhao Wang, Xinzhao Wang, Zhiyong Yu, Zhiyong Yu   +11 more
doaj   +1 more source

Effects of Pachyman in Combination with Vinorelbine and Cisplatin on Tumor Growth and the Expression of EGFR and K-ras in Mice with Lung Cancer

Digital Chinese Medicine, 2018
: Objective To examine the effects of pachyman in combination with vinorelbine and cisplatin on tumor growth and the expression of epidermal growth factor receptor (EGFR) and K-ras in a mouse model of lung cancer induced using the human lung cancer cell ...
Ke WEI, Jia-Hao ZHOU, Yong-Chao CHEN, Jia-Ming TIAN, Meng-Jin SUN, Xin-Wen DAI, Bai-Hui LI, Ling LI, Fang-Liang ZHOU, Yi NING, Jue HU, Qin XIANG, Bo ZHANG, Fang-Guo LU   +13 more
doaj   +1 more source

Real-World Efficacy of Metronomic Chemotherapy in Advanced Breast Cancer Across Molecular Subtypes. [PDF]

Cancer Med
ABSTRACT Objective Metronomic chemotherapy (mCHT) is widely used in the treatment of breast cancer due to its low toxicity and convenience. However, there remain real‐world studies with satisfactory samples focusing on mCHT in advanced breast cancer. Methods Enrolled patients were assigned into capecitabine‐based (X‐based) group and other mCHT group ...
Zhou H, Chen L, Lu Q, Wu H, Jiang K, Xu F, Wang S.   +6 more
europepmc   +2 more sources

Risk factors for venous irritation in patients receiving vinorelbine: a retrospective study

Journal of Pharmaceutical Health Care and Sciences, 2018
Background Vinorelbine is known to be effective in the treatment of non-small cell lung cancer and breast cancer. However, venous irritation is a common side effect.
Yoshihito Morimoto, Kumika Miyawaki, Reisuke Seki, Kazuhiro Watanabe, Masayoshi Hirohara, Takao Shinohara   +5 more
doaj   +1 more source

Alveolar rhabdomyosarcoma has superior response rates to vinorelbine compared to embryonal rhabdomyosarcoma in patients with relapsed/refractory disease: A meta‐analysis

Cancer Medicine, 2023
Background Patients with alveolar rhabdomyosarcoma (ARMS) have inferior outcomes compared to patients with embryonal rhabdomyosarcoma (ERMS) and more effective chemotherapy options are needed for these patients.
Wendy Allen‐Rhoades, Philip J. Lupo, Michael E. Scheurer, Yueh‐Yun Chi, John F. Kuttesch, Rajkumar Venkatramani, William H. Meyer, Leo Mascarenhas   +7 more
doaj   +1 more source

Comparison between Vinorelbine–Carboplatin and Vinorelbine–Cisplatin in Stage III–IV EGFR Mutations-Negative NSCLC

Asian Journal of Oncology, 2022
Introduction There are a substantial number of lung cancer patients with negative mutations in Indonesia. This type of cancer is deemed to be the major contributor of lung cancer patient’s death.
Laksmi Wulandari, Gatot Soegiarto, Anna Febriani, Farah Fatmawati, Wirya Sastra Amran   +4 more
doaj   +1 more source

Vinorelbine Potently Induces Placental Cell Death, Does Not Harm Fertility and is a Potential Treatment for Ectopic Pregnancy

EBioMedicine, 2018
Ectopic pregnancies complicate 1–2 pregnancies and are a leading cause of maternal death. An effective oral drug therapy that replaces surgery might make its treatment safer, cheaper, simpler and therefore more widely accessible. The only current medical
Roxanne Hastie, Elgene Lim, Pavel Sluka, Lisa Campbell, Andrew W. Horne, Lenore Ellett, Natalie J. Hannan, Fiona Brownfoot, Tu'uhevaha J. Kaitu'u-Lino, Stephen Tong   +9 more
doaj   +1 more source