Results 151 to 160 of about 13,268,265 (360)

The Alzheimer's Disease Gene SORL1 Regulates Lysosome Function in Human Microglia

Glia, EarlyView.
ABSTRACT The SORL1 gene encodes the sortilin‐related receptor protein SORLA, a sorting receptor that regulates endo‐lysosomal trafficking of various substrates. Loss of function variants in SORL1 are causative for Alzheimer's disease (AD) and decreased expression of SORLA has been repeatedly observed in human AD brains. SORL1 is highly expressed in the
Swati Mishra, Nader Morshed, Sonia Beant Sidhu, Chizuru Kinoshita, Beth Stevens, Suman Jayadev, Jessica E. Young   +6 more
wiley   +1 more source

Novikov operad is not Koszul [PDF]

arXiv, 2009
An algebra with identities $a\circ(b\circ c-c\circ b)=(a\circ b)\circ c-(a\circ c)\circ b$ and $a\circ(b\circ c)=b\circ(a\circ c)$ is called Novikov. We show that Novikov operad is not Koszul.
arxiv  

SEARCHING FOR HIGGS BOSONS ON LHC USING $b$-TAGGING [PDF]

arXiv, 1995
We demonstrate that the detection of the SM and MSSM Higgs bosons will be possible at the LHC via $t\anti t b\anti b$ and $b\anti b b\anti b$ final state, provided $b$-tagging can be performed with good efficiency and purity.
arxiv  

Isolation and specificity of cathepsin B [PDF]

FEBS Letters, 1969
B. Keil, H. Keilová
openaire   +3 more sources

Research progress of neurovascular units involved in ischemic stroke

Ibrain, EarlyView.
The brain receives less blood when an ischemic stroke develops, which damages neurons and leads to an increased release of Pro‐inflammatory mediators that activate neurovascular unit (NVU). When the tight junctions are broken and the basement membrane is disrupted by matrix metalloproteinases produced by active endothelial and pericellular cells ...
Yu Yang, Hao Tong, Zhuo‐Fan Ye, Zu‐Cai Xu, Tao Tao   +4 more
wiley   +1 more source

The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity. [PDF]

, 1991
Djordje Müsil, Damir Zucić, Vito Türk, Richard A. Engh, Irmgard Mayr, Robert Huber, Tatjana Popović, Vito Türk, Takae Towatari, Nobuhiko Katunuma   +9 more
openalex   +1 more source

Cathepsin B cleavage of Ii from class II MHC alpha- and beta-chains. [PDF]

, 1991
V E Reyes, Shuai Lü, Robert E. Humphreys   +2 more
openalex   +1 more source

Research progress of antibody coupling technique in targeted drug delivery

Interdisciplinary Medicine, EarlyView.
Abstract Antibody‐drug conjugates are a cutting‐edge biotechnology recently attracting wide attention in the medical field. Binding antibodies to drug molecules could deliver drugs precisely to the site of the lesion, which shows great potential in the treatment of tumors and immune diseases.
Meng Li, Tiantian Wang, Dan Tan, Mengqi Wang, Changhai Lei, Yuqing Wang, Shi Hu   +6 more
wiley   +1 more source

Determination of Cathepsins B and H in Sera and Synovial Fluids of Patients with Different Joint Diseases [PDF]

, 1990
D Gabrijelcic, Anthony Annan-Prah, Biljana Rodic, Blaž Rozman, V. Cotič, Vito Türk   +5 more
openalex   +1 more source

Senescent cells: A therapeutic target for osteoporosis

Cell Proliferation, Volume 55, Issue 12, December 2022., 2022
Bone is a metabolically active tissue involved in physiological processes of locomotion, support and protection of soft tissues, calcium and phosphate storage, and harbouring of bone marrow. Bone is constituted by various types of cells undergoing continuous remodelling.
Tiantian Wang, Shishu Huang, Chengqi He
wiley   +1 more source