Investigation of the Urinary Peptidome to Unravel Collagen Degradation in Health and Kidney Disease
ABSTRACT Naturally occurring fragments of collagen type I alpha 1 chain (COL1A1) have been previously associated with chronic kidney disease (CKD), with some fragments showing positive and others negative associations. Using urinary peptidome data from healthy individuals (n = 1131) and CKD patients (n = 5585) this aspect was investigated in detail ...
Ioanna K. Mina+7 more
wiley +1 more source
Studies on the inhibitors of cathepsins B and H in the brain
Tadahiro Shikimi
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Switch of CD4+ T Cell Differentiation from Th2 to Th1 by Treatment with Cathepsin B Inhibitor in Experimental Leishmaniasis [PDF]
Yoichi Maekawa+8 more
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Elevations in Cathepsin B Protein Content and Enzyme Activity Occur Independently of Glycosylation during Colorectal Tumor Progression [PDF]
Christine A. Iacobuzio‐Donahue+4 more
openalex +1 more source
Substrate/propeptide‐derived endo‐epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitors [PDF]
Norbert Schaschke+3 more
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Protease activity of cancer‐derived extracellular vesicles is quantified using a single microelectrode array in a microfluidic device to create two different electrokinetic‐based analyte collection mechanisms. First, dielectrophoresis is used to recover and purify EVs from plasma followed by electrophoresis to quantify protease activity using cleavable
Ella Stimson+9 more
wiley +1 more source
Bioactive food components and their inhibitory actions in multiple platelet pathways
A comprehensive overview of platelet multifunctional roles in CVD and other diseases and the effects of food components' modulatory effects are described. Abstract In addition to hemostasis and thrombosis, blood platelets are involved in various processes such as inflammation, infection, immunobiology, cancer metastasis, wound repair and angiogenesis ...
Diptimayee Das+7 more
wiley +1 more source
Hairpin loop mutations of chicken cystatin have different effects on the inhibition of cathepsin B, cathepsin L and papain [PDF]
Ennes A. Auerswald+5 more
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Understanding of endo/lysosomal escape of nanomaterials in biomedical application
This review summarized mainstream mechanisms of endo/lysosomal escape and design strategies of endo/lysosomal escapable nanoparticles in view of surface charge, polarity & hydrophobicity, particle morphology, and lysosomal escape agents. The utilization of endo/lysosomal escapable nanoparticles for vaccine delivery and genetic engineering are ...
Xin Wang+3 more
wiley +1 more source