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Cathepsin B Is a Prorenin Processing Enzyme
Hypertension, 1996Abstract Conversion of prorenin to renin results from proteolytic cleavage of a 43-amino-acid prorenin prosegment in renal juxtaglomerular cells. The enzyme that performs this processing is not known. Of several enzymes proposed, cathepsin B is a candidate because it colocalizes with renin in juxtaglomerular cell secretory ...
John D. Baxter +2 more
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Secretion of cathepsin B and tumour invasion
Biochemical Society Transactions, 1994Lysosomal proteases in health and disease 1,ysosomal proteases have been implicated in a variety of pathophysiological processes, such as the malignant progression of tumours [ 11, muscular dystrophy [2], acute inflammation [3] and complications accompanying the ageing process [4].
Magnus Abrahamson +2 more
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Cathepsin-B induced controlled release from peptide-capped mesoporous silica nanoparticles.
Chemistry, 2014New capped silica mesoporous nanoparticles for intracellular controlled cargo release within cathepsin B expressing cells are described. Nanometric mesoporous MCM-41 supports loaded with safranin O (S1-P) or doxorubicin (S2-P) containing a molecular gate
C. de la Torre +8 more
semanticscholar +1 more source
Analytical Chemistry, 2014
Cathepsin B has been suggested to be a prognostic marker of melanoma, glioma, and a variety of cancers such as brain, breast, colon, esophageal, gastric, lung, ovarian, and thyroid cancers.
Chan Kim +5 more
semanticscholar +1 more source
Cathepsin B has been suggested to be a prognostic marker of melanoma, glioma, and a variety of cancers such as brain, breast, colon, esophageal, gastric, lung, ovarian, and thyroid cancers.
Chan Kim +5 more
semanticscholar +1 more source
Binding Specificity of Papain and Cathepsin B
Enzyme, 1986In order to obtain useful information for the design of inhibitors of cathepsin B, an important enzyme in both physiological and pathological processes, the modes of interaction between ligands and thiol proteases (papain and cathepsin B) were analyzed.
Kenji Akahane, Hideaki Umeyama
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A radioimmunoassay for total human cathepsin B
Clinica Chimica Acta, 1982A radioimmunoassay for human cathepsin B is described, which demonstrates the usefulness of protein A-bearing Staphylococcus aureus as an immunosorbent in a system where the primary antibody IgG has a low binding affinity for protein A. The removal of bound antigen from the incubation mixture is achieved by the use of a rabbit second step antiserum ...
Anneliese D. Recklies, John S. Mort
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Cathepsin B is a mediator of organelle-specific initiation of ferroptosis.
Biochemical and Biophysical Research Communications - BBRC, 2020Feimei Kuang +4 more
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Cathepsin B Expression in Human Tumors
1996Cathepsin B has been linked to tumor progression through observations that its activity, secretion or membrane association are increased. The most malignant tumors, and specifically the cells at the invasive edge of those tumors, express the highest activity.
Isabelle M. Berquin, Bonnie F. Sloane
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Nihon geka hokan. Archiv fur japanische Chirurgie, 1994
Serum cathepsin B levels and urinary excretion of cathepsin B in the patients with gastric cancer were significantly higher than those in the control non-cancer patients. Moreover, cancer tissue cathepsin B content was significantly higher than that in the normal tissue.
T, Hirano, H, Yoshioka
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Serum cathepsin B levels and urinary excretion of cathepsin B in the patients with gastric cancer were significantly higher than those in the control non-cancer patients. Moreover, cancer tissue cathepsin B content was significantly higher than that in the normal tissue.
T, Hirano, H, Yoshioka
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Binding of Cathepsin B by Haptoglobin
1982Abstract Haptoglobin can bind lysosomal Cathepsin B 1 . The active site of the enzyme is not required for binding, but complexing results in enzyme inhibition.
David Burnett +2 more
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