Results 41 to 50 of about 118,840 (299)
The role of proteases in pathologies of the synovial joint [PDF]
, 2008 Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost frictionless surface for articulation.
Buttle, D, Jones, GC, Riley, GP
core +1 more source
The Role of Cathepsin B in Peritoneal Fibrosis due to Peritoneal Dialysis
International Journal of Nephrology, 2019 Glucose-containing peritoneal dialysis (PD) solution causes peritoneal fibrosis (PF) characterized by accumulation of extracellular matrix (ECM) in the submesothelial layer.
Su Ah Sung +4 more
doaj +1 more source
Biomolecules, 2021 Background: Epithelial ovarian cancer remains one of the leading variants of gynecological cancer with a high mortality rate. Feasibility and technical competence for screening and detection of epithelial ovarian cancer remain a major obstacle and the ...
Hemangi Ranade +7 more
doaj +1 more source
Plasma Cathepsin S and Cathepsin S/Cystatin C Ratios Are Potential Biomarkers for COPD [PDF]
Disease Markers, 2016 Purpose. This study aimed to examine whether plasma levels of cathepsin S or its inhibitor, cystatin C, may serve as biomarkers for COPD.Patients and Methods. We measured anthropometrics and performed pulmonary function tests and chest CT scans on 94 patients with COPD and 31 subjects with productive cough but no airflow obstruction (“at risk”; AR). In
Takahiro Nakajima +15 more
openaire +3 more sources
Subnormothermic Perfusion in the Isolated Rat Liver Preserves the Antioxidant Glutathione and Enhances the Function of the Ubiquitin Proteasome System. [PDF]
, 2016 The reduction of oxidative stress is suggested to be one of the main mechanisms to explain the benefits of subnormothermic perfusion against ischemic liver damage. In this study we investigated the early cellular mechanisms induced in isolated rat livers
Alva, Norma +4 more
core +4 more sources
Mechanism of p27 upregulation induced by downregulation of cathepsin B and uPAR in glioma
Molecular Oncology, 2011 Cathepsin B and urokinase plasminogen activator receptor (uPAR) are overexpressed in gliomas. Deregulation of the G1 phase cell cycle machinery is a common feature of cancers. p27Kip1 (p27) is one of the major cyclin‐CDK regulators in the G1 phase.
Sreelatha Gopinath +6 more
doaj +1 more source
Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis.
PLoS ONE, 2012 Chronic HIV infection leads to the development of cognitive impairments, designated as HIV-associated neurocognitive disorders (HAND). The secretion of soluble neurotoxic factors by HIV-infected macrophages plays a central role in the neuronal ...
Eillen J Rodriguez-Franco +8 more
doaj +1 more source
Cathepsin-mediated regulation of autophagy in saposin C deficiency [PDF]
Autophagy, 2013 Saposin C deficiency, a rare variant form of Gaucher disease, is due to mutations in the prosaposin gene (PSAP) affecting saposin C expression and/or function. We previously reported that saposin C mutations affecting one cysteine residue result in autophagy dysfunction.
Tatti M +4 more
openaire +2 more sources
Protease inhibitors targeting coronavirus and filovirus entry. [PDF]
, 2015 In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet +10 more
core +1 more source
Advanced Functional Materials, EarlyView.Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz +3 more
wiley +1 more source