Results 141 to 150 of about 29,235,414 (292)

Activity-Based Profiling of Papain-like Cysteine Proteases During Late-Stage Leaf Senescence in Barley

Plants
Leaf senescence is a developmental process that allows nutrients to be remobilized and transported to sink organs. Previously, papain-like cysteine proteases (PLCPs) have been found to be highly expressed during leaf senescence in different plant species.
Igor A. Schepetkin, Andreas M. Fischer
doaj   +1 more source

Cathepsin L proteases of the parasitic copepod, Lepeophtheirus salmonis

, 2012
The salmon louse, Lepeophtheirus salmonis, is a parasitic copepod that feeds on the mucus, skin and blood of salmonids. We describe the identification of two complete L. salmonis cathepsin L-like gene sequences and their molecular characterisation.
Dalton, John P., Mulcahy, Grace, Cunningham, E, Johnston, D, Copley, L, McCarthy, Elaine, Dalton, JP, Copley, Lorraine, Jackson, D, Johnston, DA, Mulcahy, G, Jackson, David, Cunningham, Eleanor, McCarthy, E   +13 more
core   +1 more source

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source

Regional localization of the porcine cathepsin H (CTSH) and cathepsin L (CTSL) genes

, 2001
The 3'-untranslated region (3¢-UTR) of the porcine cathepsin H (CTSH) cDNA sequence (EMBL no. AF001169)1 was used to design two polymerase chain reaction (PCR) primers that amplified a 100-bp fragment from pig total genomic DNA.
Russo V., Davoli R., Yerle M., Zijlstra C., Bosma A. A., Fontanesi L.   +5 more
core   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Peptidomimetic 2-cyanopyrrolidines as potent selective cathepsin L inhibitors

, 2008
Cathepsins have been found to have important physiological roles. The implication of cathepsin L in various types of cancers is well established. In a search for selective cathepsin L inhibitors as anticancer agents, a series of 2-cyanoprrolidine ...
Chouhan, Bishram S., Giridhar, Rajani, Yadav, Mange R., Menard, Robert, Shinde, Anil K.   +4 more
core   +1 more source

Integrative Genomic and Functional Investigation of the Multi‐Layered Genetic Architecture Between Anorexia Nervosa and Bone Loss

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Bone loss is a severe and often irreversible complication of anorexia nervosa (AN), yet the genetic mechanisms underlying this comorbidity remain underexplored. This study focuses on constructing a comprehensive genetic architecture between AN and estimated calcaneal bone mineral density (eBMD).
Tao Han, Yuke Wang, Yixiong Dang, Rong Xiang, Yan Zeng, Sheng He, Ye Ju, Zilan Chen, Ting Liu, Zihao Li, Yuqi Pang, Wanyi Tan, Jue Xu, Jingwen Jiang, Xia Jiang   +14 more
wiley   +1 more source

The release of lysosomal Pro⁃cathepsin L of BV⁃2 cells upon lipopolysaccharide stimulation and its toxicity to neurons

Chinese Journal of Contemporary Neurology and Neurosurgery, 2011
Objective To investigate the secretion of lysosomal Pro ⁃ cathepsin L and its contribution to neuronal apoptosis upon lipopolysaccharide (LPS) stimulation.
Hui ZHANG, Guidong LIU, Yue LOU, Qin XIAO, Shengdi CHEN   +4 more
doaj  

DENV2 NS1 increases the activity of cathepsin L protease.

, 2016
(A) Cathepsin L proteolytic activity (Magic Red assay, in red) in HPMEC monolayers over time (hpt) after treatment with DENV2 or WNV NS1 (5 μg/ml) and cathepsin L or B inhibitors (10 μM). Nuclei are stained with Hoechst (blue).
Eva Harris (27355), Henry Puerta-Guardo (400106), Dustin R. Glasner (2832614)   +2 more
core   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source