Results 291 to 300 of about 108,576 (328)

Bufalin Inhibits Cytokine Storm by Regulating TLR4/TLR3 Signaling Pathway

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Bufalin is one main component of the dried venom from Bufo gargarizans Cantor, which has anti‐tumor, cardiotonic, anti‐inflammatory and other physiological activities. However, in recent years, researchers have mainly paid attention to its anti‐tumor effect and neglected its anti‐inflammatory effect.
Xixi Liu, Chencheng Li, Jing Yang, Weiguang Zhang, Zhongxiao Hu, Xiaoli Zhang, Reaila Jianati, Fang Tian, Xingbin Dai, Zuqiong Xu, Biqing Chen, Xuejun Zhu   +11 more
wiley   +1 more source

Cathepsin L promotes oesophageal squamous cell carcinoma development and may be associated with tumour-associated macrophages. [PDF]

Heliyon
Zhang Z, Wang J, Shi Y, Wang B, Wang D.
europepmc   +1 more source

In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug Transporters

The Journal of Clinical Pharmacology, Volume 66, Issue 2, February 2026.
Abstract Bemnifosbuvir is a novel oral guanosine nucleotide prodrug candidate for the treatment of chronic hepatitis C virus infection. Potential drug–drug interactions (DDIs) of bemnifosbuvir as a substrate or perpetrator with regard to ATP‐binding cassette (ABC) and solute carrier (SLC) transporters were evaluated in vitro and in clinical studies ...
Xiao‐Jian Zhou, Alex Vo, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Arantxa Horga, Nancy Agrawal, Janet Hammond   +9 more
wiley   +1 more source

A serological test based on mutated recombinant Fasciola hepatica cathepsin L protease for the diagnosis of equine fasciolosis

Philipp A. Kronenberg, Nathalie Fouché, Mary Sekiya, Pauline Liechti, Caroline F. Frey, Grace Mulcahy, Ramon M. Eichenberger   +6 more
openalex   +1 more source

Largely Distinct Post‐Translational Modifications Differentiate Skeletal Muscle Wasting Caused by Cancer, Dexamethasone and Aging

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Skeletal muscle wasting and weakness are prominent disease features. Originally considered to arise from common transcriptional changes, recent analyses demonstrated that different stimuli induce muscle wasting via largely distinct mRNA and protein changes.
Anna Stephan, Flavia A. Graca, Suresh Poudel, Yingxue Fu, Yong‐Dong Wang, Myriam Labelle, Fabio Demontis   +6 more
wiley   +1 more source

Molecular characterization of EcCLP1, a new putative cathepsin L protease from Echinococcus canadensis. [PDF]

Parasite
Naidich A, Gutierrez AM, Camicia F.
europepmc   +1 more source

Modulation of cathepsin L expression and NF-kB signalling pathway effectors by advanced glycation end-products in retinal pigment epithelial cells

, 2016
Nur Musfirah Mahmud, Umar Sharif, Paul Kay, Tengku Ain Kamalden, Yit C. Yang, Simon Harding, Luminita Paraoan   +6 more
openalex   +1 more source

Identification of Dual Inhibitors Targeting Main Protease (M^pro) and Cathepsin L as Potential Anti-SARS-CoV-2 Agents. [PDF]

ACS Med Chem Lett
Previti S, Ettari R, Calcaterra E, Roggia M, Natale B, Weldert AC, Müller-Ruttloff C, Salisch F, Irto A, Cigala RM, Ziebuhr J, Schirmeister T, Cosconati S, Zappalà M.   +13 more
europepmc   +1 more source

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Anti-Cathepsin L Monoclonal Antibodies That Distinguish Cathepsin L from Cathepsin V

Biological Chemistry, 2001
Cathepsin L is a lysosomal cysteine protease involved in intracellular protein degradation. Recently, several new cysteine proteases have been identified. Human cathepsin V, a thymus- and testis-specific human cysteine protease, shares 78% sequence identity with human cathepsin L.
N, Kopitar-Jerala, T, Bevec, D, Barlic-Maganja, F, Gubensek, V, Turk   +4 more
openaire   +2 more sources

Cathepsin L in glioma progression: Comparison with cathepsin B

Cancer Detection and Prevention, 2005
Lysosomal cysteine cathepsins have been implicated in tumor progression. This study is aimed to reveal differential expression and compare the prognostic significance of cathepsins B and L in glioma patients.The histological slides of 82 patients with primary astrocytic tumors were reviewed.
Tadej, Strojnik, Rajko, Kavalar, Miha, Trinkaus, Tamara T, Lah   +3 more
openaire   +2 more sources