Results 271 to 280 of about 104,138 (306)

Role of calcium in the initiation of fast axonal transport of protein: Effects of divalent cations

Journal of Neurobiology, 1977
AbstractFast axonal transport of [3H]protein has been examined in bullfrog primary afferent neurons incubated in media supplemented with divalent cations that can act as agonists or antagonists of calcium ions. Incubation in calcium‐free medium (CFM) had no effect on the rate of transport, but reduced the amount of transported [3H]protein by 40–60 ...
Richard Hammerschlag, Charles Bakhit, Arlene Y. Chiu, Anant R. Dravid   +3 more
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Interaction among anion, cation and glucose transport proteins in the human red cell

The Journal of Membrane Biology, 1989
The time course of binding of the fluorescent stilbene anion exchange inhibitor. DBDS (4.4'-dibenzamido-2.2'-stilbene disulfonate), to band 3 can be measured by the stopped-flow method. We have previously used the reaction time constant. tau DBDS, to obtain the kinetic constants for binding and, thus, to report on the conformational state of the band 3
A, Janoshazi, A K, Solomon
openaire   +2 more sources

Phylogenomic analysis of Cation Diffusion Facilitator proteins uncovers Ni2+/Co2+ transporters

Metallomics, 2013
The ubiquitous Cation Diffusion Facilitator proteins (CDF) play a key role in maintaining the cellular homeostasis of essential metal ions. Previous neighbor-joining phylogenetic analysis classified CDF proteins into three substrate-defined groups: Zn(2+), Fe(2+)/Zn(2+) and Mn(2+). These studies were unable to discern substrate-defined clades for Ni(2+)
Ciro, Cubillas, Pablo, Vinuesa, Maria Luisa, Tabche, Alejandro, García-de los Santos   +3 more
openaire   +2 more sources

Protein intake and cation transport in the loop of Henle.

The Journal of laboratory and clinical medicine, 1989
High-protein intake enhances maximal urinary concentrating ability and suppresses tubuloglomerular feedback activity in a manner that correlates with enhanced salt reabsorption in the loop of Henle. In this article we describe studies designed to localize the site at which protein intake alters loop sodium uptake (JNa) in rats fed diets containing ...
F D, Seney, D, Marver
openaire   +1 more source

Interplay of the Organic Cation Transporters OCT1 and OCT2 with the Apically Localized Export Protein MATE1 for the Polarized Transport of Trospium

Molecular Pharmaceutics, 2019
The anticholinergic drug trospium is secreted into urine and, to a smaller extent, into bile. Chemically, it is an organic cation, and it is a substrate of the uptake transporters OCT1 and OCT2 as well as for the export proteins MATE1 and MATE2-K as determined in uptake studies using HEK293 cells.
Birgit Deutsch, Claudia Neumeister, Ulrich Schwantes, Martin F. Fromm, Jörg König   +4 more
openaire   +2 more sources

DIVALENT CATION SPECIFICITY OF THE CALCIUM REQUIREMENT FOR FAST TRANSPORT OF PROTEINS IN AXONS OF DESHEATHED NERVES

Journal of Neurochemistry, 1979
AbstractThe presence of a requirement for calcium during the fast transport of [3H]protein in axons was assessed in desheathed spinal nerves of bullfrog. The nerves were desheathed locally along 4 mm of their length, and desheathing was judged effective on the basis of an enhanced uptake of [3H]leucine into that region of nerve trunk.
P A, Lavoie, F, Bolen, R, Hammerschlag
openaire   +2 more sources

Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4)

Pharmacogenetics and Genomics, 2007
OCTN1 is a multispecific transporter of organic cations and zwitterions, including several clinically important drugs as well as the antioxidant ergothioneine. OCTN1 is highly expressed in the kidney, where it is thought to aid in active secretion of organic cations, and may facilitate the active reabsorption of ergothioneine.
Thomas J, Urban, Chen, Yang, Leah L, Lagpacan, Chaline, Brown, Richard A, Castro, Travis R, Taylor, Conrad C, Huang, Douglas, Stryke, Susan J, Johns, Michiko, Kawamoto, Elaine J, Carlson, Thomas E, Ferrin, Esteban G, Burchard, Kathleen M, Giacomini   +13 more
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Protein kinase inhibition differentially regulates organic cation transport.

Canadian journal of physiology and pharmacology, 2010
Previous studies showed that amantadine transport increased while tetraethylammonium (TEA) transport decreased in kidney tissue from diabetic rats. Changes in transport activity were reversed by exogenous insulin. We hypothesized that this difference in transport regulation is due to differential regulation of different transport systems.
Alexander M, Gerlyand, Daniel S, Sitar
openaire   +1 more source

Protein adsorption and transport in cation exchangers with a rigid backbone matrix with and without polymeric surface extenders

Biotechnology Progress, 2011
AbstractWe compare the properties and protein adsorption characteristics of two polymeric cation exchangers: UNOsphere S, which has an open macroporous architecture, and Nuvia S, which is based on a very similar backbone matrix but contains sulfonated polymeric surface extenders. A monoclonal IgG and lysozyme were used as model adsorbates.
Ernie X, Pérez Almodóvar, Yinying, Tao, Giorgio, Carta   +2 more
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[The relationship between the cation and protein content, cationic transport and the rate of protein synthesis detected in cells in the presence and in the absence of ouabain].

Tsitologiia, 1992
The measurements were made of monovalent cation (K+ + Rb+, Na+) and protein contents, of leucin incorporation into the protein (protein synthesis), and of ouabain-sensitive K+ influx during the growth of the Jurkat culture cells in the presence or in the absence of ouabain. All the data were calculated per cell. The time dependences of these parameters
V V, Osipov, L N, Glushankova, F V, Toropova, I I, Marakhova   +3 more
openaire   +1 more source