Results 291 to 300 of about 623,994 (347)

Phylogenomic analysis of Cation Diffusion Facilitator proteins uncovers Ni2+/Co2+ transporters

Metallomics, 2013
The ubiquitous Cation Diffusion Facilitator proteins (CDF) play a key role in maintaining the cellular homeostasis of essential metal ions. Previous neighbor-joining phylogenetic analysis classified CDF proteins into three substrate-defined groups: Zn(2+), Fe(2+)/Zn(2+) and Mn(2+). These studies were unable to discern substrate-defined clades for Ni(2+)
Ciro, Cubillas, Pablo, Vinuesa, Maria Luisa, Tabche, Alejandro, García-de los Santos   +3 more
openaire   +2 more sources

Transport of asymmetric dimethylarginine (ADMA) by cationic amino acid transporter 2 (CAT2), organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1)

Amino Acids, 2013
Asymmetric dimethylarginine (ADMA), inhibiting the nitric oxide (NO) synthesis from L-arginine, is a known cardiovascular risk factor. Our aim was to investigate if ADMA and/or L-arginine are substrates of the human cationic amino acid transporters 2A (CAT2A, SLC7A2A) and 2B (CAT2B, SLC7A2B), the organic cation transporter 2 (OCT2, SLC22A2), and the ...
Joachim, Strobel, Fabian, Müller, Oliver, Zolk, Beate, Endreß, Jörg, König, Martin F, Fromm, Renke, Maas   +6 more
openaire   +2 more sources

Protein partitioning and transport in supported cationic acrylamide‐based hydrogels

AIChE Journal, 2003
AbstractThe partitioning and transport of myoglobin in cationic, acrylamide‐based hydrogels are studied by a microscopic visualization method. Homogeneous cationic gels are synthesized inside fused‐silica capillaries with a square section, which allow a direct determination of protein concentration profiles during transient adsorption and desorption ...
Shawn M. Russell, Emily B. Belcher, Giorgio Carta   +2 more
openaire   +1 more source

Peptide models for protein-mediated cation transport

Canadian Journal of Biochemistry, 1980
Substances which can perturb the transmembrane cation balance in a predictable manner have wide-ranging uses in the study of cellular processes. We have undertaken to examine transmembrane calcium transport on the molecular level through the design and synthesis of a series of ionophoric peptides as models for protein-mediated calcium transport ...
openaire   +2 more sources

The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations

Trends in Pharmacological Sciences, 2006
Multidrug and toxic compound extrusion (MATE) proteins, comprising the most recently designated family of multidrug transporter proteins, are widely distributed in all kingdoms of living organisms, although their function is far from understood. The bacterial MATE-type transporters that have been characterized function as exporters of cationic drugs ...
Hiroshi, Omote, Miki, Hiasa, Takuya, Matsumoto, Masato, Otsuka, Yoshinori, Moriyama   +4 more
openaire   +2 more sources

Interaction among anion, cation and glucose transport proteins in the human red cell

The Journal of Membrane Biology, 1989
The time course of binding of the fluorescent stilbene anion exchange inhibitor. DBDS (4.4'-dibenzamido-2.2'-stilbene disulfonate), to band 3 can be measured by the stopped-flow method. We have previously used the reaction time constant. tau DBDS, to obtain the kinetic constants for binding and, thus, to report on the conformational state of the band 3
A, Janoshazi, A K, Solomon
openaire   +2 more sources

PDZ Adaptor Protein PDZK2 Stimulates Transport Activity of Organic Cation/Carnitine Transporter OCTN2 by Modulating Cell Surface Expression

Drug Metabolism and Disposition, 2006
A part of the organic cation transporter families (OCT3, OCTN1, and OCTN2) has recently been identified to physically interact with PDZ (PSD95, Dlg, and ZO1) domain-containing proteins, although the physiological relevance of such interaction has not yet been fully examined.
Chizuru, Watanabe, Yukio, Kato, Tomoko, Sugiura, Yoshiyuki, Kubo, Tomohiko, Wakayama, Shoichi, Iseki, Akira, Tsuji   +6 more
openaire   +2 more sources

Protein kinase inhibition differentially regulates organic cation transport.

Canadian journal of physiology and pharmacology, 2010
Previous studies showed that amantadine transport increased while tetraethylammonium (TEA) transport decreased in kidney tissue from diabetic rats. Changes in transport activity were reversed by exogenous insulin. We hypothesized that this difference in transport regulation is due to differential regulation of different transport systems.
Alexander M, Gerlyand, Daniel S, Sitar
openaire   +1 more source

Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4)

Pharmacogenetics and Genomics, 2007
OCTN1 is a multispecific transporter of organic cations and zwitterions, including several clinically important drugs as well as the antioxidant ergothioneine. OCTN1 is highly expressed in the kidney, where it is thought to aid in active secretion of organic cations, and may facilitate the active reabsorption of ergothioneine.
Thomas J, Urban, Chen, Yang, Leah L, Lagpacan, Chaline, Brown, Richard A, Castro, Travis R, Taylor, Conrad C, Huang, Douglas, Stryke, Susan J, Johns, Michiko, Kawamoto, Elaine J, Carlson, Thomas E, Ferrin, Esteban G, Burchard, Kathleen M, Giacomini   +13 more
openaire   +2 more sources

Structural Requirements for Drug Inhibition of the Liver Specific Human Organic Cation Transport Protein 1

Journal of Medicinal Chemistry, 2008
The liver-specific organic cation transport protein (OCT1; SLC22A1) transports several cationic drugs including the antidiabetic drug metformin and the anticancer agents oxaliplatin and imatinib. In this study, we explored the chemical space of registered oral drugs with the aim of studying the inhibition pattern of OCT1 and of developing predictive ...
Gustav, Ahlin, Johan, Karlsson, Jenny M, Pedersen, Lena, Gustavsson, Rolf, Larsson, Pär, Matsson, Ulf, Norinder, Christel A S, Bergström, Per, Artursson   +8 more
openaire   +2 more sources