Results 51 to 60 of about 72,832 (304)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Hydrophobic-cationic peptides modulate RNA polymerase ribozyme activity by accretion

Nature Communications, 2022
Macromolecular aggregates may have played an important role in the origin of life. Here, the authors report hydrophobic-cationic peptides that form insoluble aggregates, which reversibly accrete RNA on their surfaces, and enhance RNA polymerization by a ...
Peiying Li, Philipp Holliger, Shunsuke Tagami   +2 more
doaj   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Methyl Methacrylate and Alpha-Methyl Styrene: New Strategy for Synthesis of Bloc Copolymers for Use in Potential Biomedical Applications Generated by an Ecologic Catalyst Called Maghnite (Algerian MMT)

Bulletin of Chemical Reaction Engineering & Catalysis, 2016
A new model for synthesis of the plastics, block copolymers were prepared from methyl methacrylate (MMA) and alpha-methyl styrene (α-MS) by cationic copolymerization in the presence of a new and efficient catalyst of “Maghnite-Na” at 0 °C in bulk.
Moulkheir Ayat, Mohamed Belbachir, Abdelkader Rahmouni   +2 more
doaj   +1 more source

Copolymerization of ring-opening oxaspiro comonomer with denture base acrylic resin by free-radical/cationic hybrid polymerization

Journal of Pharmacy and Bioallied Sciences, 2021
Background: Polymerization shrinkage is an innate characteristic of thermo-polymerized denture base acrylic resin. Volumetric shrinkage is still a problem, although myriad material modifications.
Ranganathan Ajay, Vikraman Rakshagan, Murugesan Sreevarun, Dharanividhya Bhuvaneshkumar, Sekaran SajidaBegum, Veerakumar Vignesh   +5 more
doaj   +1 more source

Novel "green" catalysts for controlled ring-opening polymerization of lactide [PDF]

, 2010
Syntéza polylaktidu (PLA) polymerací za otevření kruhu cyklického monomeru (ROP) může být uskutečněna různými způsoby. Literatura uvádí více než 100 katalytických systémů, jejichž pomocí lze polylaktid a jiné biodegradabilní alifatické polyestery získat.
Surman, František
core  

Surface modification of UV Cured epoxy resins by click Chemistry

, 2010
A novel method for surface modification of UV-cured epoxy network was described. Photoinitiated cationic copolymerization of a bisepoxide, namely 3,4-epoxy cyclohexylmethyl 3,4-epoxycyclohexanecarboxylate (EEC) with epibromohydrine (EBH) by using a ...
Abadie, Adamson, Ak, Boey, Chandran, Chen, Collman, Dag, Decker, Decker, Decker, Dufour, Durmaz, Erbil, Ergin, Gacal, Gacal, Gao, Haensch, Haensch, Haensch, Karagoz, Kim, Kiskan, Kolb, Kukut, Li, Lummerstorfer, Lutz, Nagai, Nakajima, Opsteen, Parrish, Ranjan, Rengifo, Sangermano, Sangermano, Schlegel, Sun, Takimoto, Tasdelen, Tornoe, Tsarevsky, Tsarevsky, Wang, Yagci, Yagci, Yagci   +47 more
core   +1 more source

Zirconium and titanium complexes supported by tridentate LX2 ligands having two phenolates linked to furan, thiophene, and pyridine donors: precatalysts for propylene polymerization and oligomerization [PDF]

, 2008
Zirconium and titanium complexes with tridentate bis(phenolate)-donor (donor = pyridine, furan and thiophene) ligands have been prepared and investigated for applications in propylene polymerization.
Agapie, Theodor, Bercaw, John E., DiPasquale, Antonio G., Henling, Lawrence M., Rheingold, Arnold L.   +4 more
core   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source