Results 41 to 50 of about 344,099 (237)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Synthesis and butadiene polymerization behaviors of cationic cobalt-based catalyst

Journal of Saudi Chemical Society, 2017
A series of cationic cobalt-based compounds bearing different neutral N-bearing ligands (1,10-phenanthroline, bipyridine, benzimidazole, terpyridine) and anionic ligands (trifluoromethanesulfonate, methanesulfonate) were synthesized and the simple ...
Li Liu, Xu Zhang, Heng Liu, Xuequan Zhang, Qihu Qin, Guangping Sun, Hexin Zhang   +6 more
doaj   +1 more source

Naphthoxy Bounded Ferrocenium Salts as Cationic Photoinitiators for Epoxy Photopolymerization

International Journal of Photoenergy, 2009
To improve the absorption and the bulk of arene ligands, two naphthoxy bounded ferrocenium salts as new cationic photoinitiators, (η6-α-naphthoxybenzene) (η5-cyclopentadienyl) iron hexafluorophosphate (NOFC-1) and (η6-β-naphthoxybenzene) (η5 ...
Zh. Q. Li, M. Li, G. L. Li, Y. Chen, X. N. Wang, T. Wang   +5 more
doaj   +1 more source

Complexes of aluminum, iron(III), and gallium(III) chlorides with ethers in synthesis of highly reactive polyisobutylene

Журнал Белорусского государственного университета: Химия, 2020
In this review, the latest achievements in the field of cationic polymerization of isobutylene catalyzed by the complexes of conventional Lewis acids with ethers are presented.
Sergei V. Kostjuk
doaj   +1 more source

Recent Advances in bis-Chalcone-Based Photoinitiators of Polymerization: From Mechanistic Investigations to Applications

Molecules, 2021
Over the past several decades, photopolymerization has become an active research field, and the ongoing efforts to develop new photoinitiating systems are supported by the different applications in which this polymerization technique is involved ...
Nicolas Giacoletto, Frédéric Dumur
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Cationic Polymerization of Vinyl Ethers Containing an Oxyethylene Chain and a Urethane Linkage in Their Substituents [PDF]

, 2007
2-(2-vinyloxyethoxy)ethyl phenylcarbamate (VEEPC)and 2-[2-(2-vinyloxyethoxy)ethoxy] ethy phenylcarbamate (VEEEPC) were synthesized by the reactions of pheny isocyanate with di(ethylene glycol) mono vinyl ether, respectively, and were purified by ...
市村, 健太, ICHIMURA, Kenta, 橋本, 保, HASHIMOTO, Tamotsu   +3 more
core  

Observation of eliminative cationic polymerization within van der Waals clusters [PDF]

, 1991
We report the first observation of eliminative cationic polymerization within van der Waals (vdW) clusters following electron impact ionization at pressures of 10−8 Torr.
El-Shall, M. Samy, Schriver, K. E., K. E. Schriver, M. Samy El-Shall   +3 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source