Results 131 to 140 of about 39,164 (258)

Shared and specific molecular mechanisms of proteasome inhibitors in chemotherapy‐induced peripheral neurotoxicity

British Journal of Pharmacology, EarlyView.
This study compares the molecular mechanisms of chemotherapy‐related peripheral neurotoxicity of two proteasome inhibitors, bortezomib and carfilzomib, using a multidisciplinary approach to reveal that, alongside shared effects on mitochondria structure and function, the more neurotoxic drug BTZ has specific effects on microtubules and mitochondrial ...
Federico Iseppon, Alessio Malacrida, Alessia Chiorazzi, Annalisa Canta, Paola Alberti, Valentina Alda Carozzi, Eleonora Pozzi, Virginia Rodriguez‐Menendez, Laura Cherchi, Valentina Fabbro, Lisa Pagani, Elisa Tonelli, Laura Tapella, Andrea Mattarei, Sara Palermo, Daniele Cartelli, Mario Mauri, Noemi Scimia, Serena Stanga, Dmitry Lim, Carla Distasi, Marta Delconti, Clizia Chinello, Patricia Morcillo, Maria Elena Pero, Francesca Bartolini, Guido Cavaletti, Cristina Meregalli   +27 more
wiley   +1 more source

Harnessing Metabolic Priming to Engineer Human Nucleus Pulposus Macromass Overcoming Scalability‐Phenotype Tradeoff

Cell Proliferation, EarlyView.
Human platelet lysate acts as a metabolic primer for hNPCs, enhancing fatty acid oxidation to drive proliferation while preserving phenotype. This enables construction of high‐quality, large‐size macromasses without necrotic defects, demonstrating exceptional efficacy in repairing degenerated discs in situ and providing a novel paradigm for ...
Yingbo Wang, Ou Hu, Jian Wu, Sha Huang, Peng Lin, Pulin Yan, Yangyang Li, Huaijian Jin, Yutong Wu, Jun Zhu, Jungang Pu, Bo Hu, Jian He, Yibo Gan, Peng Liu   +14 more
wiley   +1 more source

Anesthetic challenges and successful management of a child with Pelizaeus-Merzbacher disease using general and caudal anesthesia.

J Anaesthesiol Clin Pharmacol, 2018
Kapoor R, Zavala AM, Van Meter A, Williams UU, Porche VH, Owusu-Agyemang P.   +5 more
europepmc   +1 more source

Point-of-care-ultrasound measurements of cardiovascular indices across awake, sedated, anesthetized, and recovered states in dogs. [PDF]

Front Vet Sci
Warhoe J, Zersen KM, Cavanagh AA.
europepmc   +1 more source

Neuroimmune alterations and nociceptive behavior in oral carcinogenesis in rats

European Journal of Oral Sciences, EarlyView.
Abstract Oral cancer pain is a frequent and debilitating symptom associated with tumor progression. Although neuronal mechanisms have been extensively studied, the role of immune and glial cells in the trigeminal nociceptive pathway remains poorly understood.
Joana Maria dos Santos Alves, Luiza Clertiani Vieira Alves, Vitória Tavares Bessa, Anamaria Falcão Pereira, Roberto César Pereira Lima Júnior, Mariana Lima Vale, Karuza Maria Alves Pereira, Delane Viana Gondim   +7 more
wiley   +1 more source

Comparative Study of the Effect of Continuous Caudal Epidural With General Anesthesia Versus General Anesthesia on Intraoperative and Postoperative Analgesic Requirements for Lumbar Fixation. [PDF]

Anesthesiol Res Pract
Samaan PME, Shawky EAM, Ghallab MAEA, El-Hennawy AME, Mohamed OMZ.   +4 more
europepmc   +1 more source

An unusual presentation of osteochondrosis in the elbows and tarsi of a Friesian colt

Equine Veterinary Education, EarlyView.
Summary This case report describes the clinical, diagnostic imaging results and post‐mortem findings in a foal that underwent reassessment following surgical management of angular limb deformities (ALD) and acute onset of gait abnormalities. Upon presentation, the foal showed an abnormal stiff gait characterised by bilateral medial limb collapse during
A. Torrent‐Crosa, A. Merchán‐Muñoz, C. Co, E. Borkowski   +3 more
wiley   +1 more source

Different injection speeds produce distinct temporal dynamics of optic nerve sheath diameter increase during caudal block in children: a prospective randomized trial. [PDF]

Front Pediatr
Yang W, Han D, Xie S, Zou S, Ma Y, Huang G, Pan S.   +6 more
europepmc   +1 more source

An Evaluation of Caudal Anesthesia

Korean Journal of Anesthesiology, 1995
Seog Hyun Jung, Jung Gil Hong, Byung Kwon Kim   +2 more
openaire   +1 more source

How to Do a Novel Transversalis Fascial Mesh Repair for Complex Ventral Hernias

ANZ Journal of Surgery, EarlyView.
Mina Sarofim, Ernest Cheng, Andrew Gilmore   +2 more
wiley   +1 more source