Results 91 to 100 of about 12,377 (183)

A Localized Complex of Two Protein Oligomers Controls the Orientation of Cell Polarity

mBio, 2017
Signaling hubs at bacterial cell poles establish cell polarity in the absence of membrane-bound compartments. In the asymmetrically dividing bacterium Caulobacter crescentus, cell polarity stems from the cell cycle-regulated localization and turnover of ...
Adam M. Perez, Thomas H. Mann, Keren Lasker, Daniel G. Ahrens, Michael R. Eckart, Lucy Shapiro   +5 more
doaj   +1 more source

The ribonuclease E regulator RebA is essential for diazotrophic growth in the cyanobacterium Anabaena PCC 7120

mLife, Volume 4, Issue 5, Page 516-526, October 2025.
Abstract Ribonuclease E (RNase E) is central to bacterial RNA metabolism. In cyanobacteria, its activity is inhibited by RebA, a key mechanism for controlling cell morphology. Here, we demonstrate that rebA is essential for diazotrophic growth of Anabaena PCC 7120, a filamentous cyanobacterium capable of forming heterocysts—specialized nitrogen‐fixing ...
Sujuan Liu, Zhenyu Wang, Guiming Lin, Wenkai Li, Xiaoli Zeng, Ju‐Yuan Zhang, Cheng‐Cai Zhang   +6 more
wiley   +1 more source

Complete genome sequence of Caulobacter crescentus [PDF]

Proceedings of the National Academy of Sciences, 2001
The complete genome sequence of Caulobacter crescentus was determined to be 4,016,942 base pairs in a single circular chromosome encoding 3,767 genes. This organism, which grows in a dilute aquatic environment, coordinates the cell division cycle and multiple cell differentiation events.
W C, Nierman, T V, Feldblyum, M T, Laub, I T, Paulsen, K E, Nelson, J A, Eisen, J F, Heidelberg, M R, Alley, N, Ohta, J R, Maddock, I, Potocka, W C, Nelson, A, Newton, C, Stephens, N D, Phadke, B, Ely, R T, DeBoy, R J, Dodson, A S, Durkin, M L, Gwinn, D H, Haft, J F, Kolonay, J, Smit, M B, Craven, H, Khouri, J, Shetty, K, Berry, T, Utterback, K, Tran, A, Wolf, J, Vamathevan, M, Ermolaeva, O, White, S L, Salzberg, J C, Venter, L, Shapiro, C M, Fraser, J, Eisen   +37 more
openaire   +2 more sources

Mechanisms and Pathological Significance of Liquid–Liquid Phase Separation in Bacteria

The FASEB Journal, Volume 39, Issue 18, 30 September 2025.
LLPS in bacterial infections. In biological systems, the molecular mechanisms underlying LLPS are primarily driven by multivalent protein–protein interactions, protein‐nucleic acid interactions, and intramolecular interactions mediated by IDR. Through LLPS, proteins form condensates that function as ‘microfactories,’ playing crucial roles in regulating
Yanxiao Zhao, Enhui Dai, Mentao Zhang, Yifan Wu, Dongjie Sun, Jiabo Ding   +5 more
wiley   +1 more source

Genome‐Wide Analysis of DtxR and HrrA Regulons Reveals Novel Targets and a High Level of Interconnectivity Between Iron and Heme Regulatory Networks in Corynebacterium glutamicum

Molecular Microbiology, Volume 124, Issue 2, Page 115-130, August 2025.
Iron is essential for life, yet excessive levels can quickly lead to cellular damage via oxidative stress, underscoring the need for global regulators of iron and heme homeostasis. In this study, we present a genome‐wide analysis of the binding patterns of DtxR and HrrA in Corynebacterium glutamicum . Our findings highlight the interconnected nature of
Aileen Krüger, Ulrike Weber, Julia Frunzke   +2 more
wiley   +1 more source

Cell cycle constraints on capsulation and bacteriophage susceptibility

eLife, 2014
Despite the crucial role of bacterial capsules in pathogenesis, it is still unknown if systemic cues such as the cell cycle can control capsule biogenesis.
Silvia Ardissone, Coralie Fumeaux, Matthieu Bergé, Audrey Beaussart, Laurence Théraulaz, Sunish Kumar Radhakrishnan, Yves F Dufrêne, Patrick H Viollier   +7 more
doaj   +1 more source

Metabolic Engineering of Komagataella phaffii and Process Optimization for Biosynthesis of 1,2,4‐Butanetriol From Xylose

Biotechnology Journal, Volume 20, Issue 7, July 2025.
Graphical Abstract and Lay Summary The yeast K. phaffii was engineered to produce butanetriol from xylose employing a modified Damhs pathway. The optimization of oxygen availability, culture pH, and initial cell density resulted in a 147% increase in renewable butanetriol production in batch fermentation.
Débora Trichez, Thályta Pacheco, Clara Vida G. C. Carneiro, Jessica C. Bergmann, João Ricardo M. de Almeida   +4 more
wiley   +1 more source

Toward Design Principles for Biomolecular Condensates for Metabolic Pathways

Advanced Biology, Volume 9, Issue 5, May 2025.
Biomolecular condensates are membrane‐less compartments found through‐out nature which can serve as reaction crucibles for biochemical processes. This review explores the design strategies underlying how condensates can be used in biotechnology to enhance multistep enzyme cascades including enhancement by mass action and substrate channeling, and ...
Alain A.M. André, Nikita Rehnberg, Ankush Garg, Magnus Kjærgaard   +3 more
wiley   +1 more source

TipN’s involvement with centromere segregation in Caulobacter crescentus

, 2023
ABSTRACT Bacteria’s ability to maintain chromosomal integrity throughout their life cycle is crucial for their survival. In Caulobacter crescentus , the polar factor TipN has been proposed to be involved with the partitioning system ParABS. However, cells with tipN
Morgan Letzkus, Corey Trela, Paola E. Mera   +2 more
openaire   +2 more sources

Characterization of the Weimberg Pathway in Caulobacter crescentus

Fermentation, 2018
Caulobacter crescentus is a gram-negative bacterium that can utilize xylose as a substrate using the Weimberg pathway, which converts xylose to α-ketoglutarate in five steps without carbon loss.
Henrik Almqvist, Sara Jonsdottir Glaser, Celina Tufvegren, Lisa Wasserstrom, Gunnar Lidén   +4 more
doaj   +1 more source