Results 211 to 220 of about 23,286,860 (307)

Unraveling the genetic basis of metabolic traits and benign adrenal tumors: a comprehensive causal analysis. [PDF]

Int J Clin Exp Pathol
Chen J, Li X, Zuo J, Fu Y, Zhao L, Xie J, Deng C, Zhan P, Li Z, Chen S, Li H, Gong Y, Chen P, Zhao J, Chen B, Wang H, Fu S.   +16 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Precuneus Region Drives Brain Network Changes in Tremor-Dominant Parkinson's Disease: Insights from a Morphological Causal Analysis. [PDF]

MedComm (2020)
Zhang M, Zhou S, Yang P, Wang H, Ding J, Wang X, Chen X, Zhang C, Wang A, Gao Y, Liu Q, Ji Y, Jiang Y, Shi L, Han C, Yang Z, Feng T, Zhang J, Meng F.   +18 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Composite variable bias: causal analysis of weight outcomes. [PDF]

Int J Obes (Lond)
Ali R, Prestwich A, Ge J, Griffiths C, Allmendinger R, Shahgholian A, Chen YW, Mansournia MA, Gilthorpe MS.   +8 more
europepmc   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Developing a monitoring and assessment program with diatoms, an improved metric calculation method, and causal analysis for Big Cypress National Preserve, Florida (USA). [PDF]

Environ Monit Assess
Stevenson RJ, Whelan KRT, Prats MC.
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Local habitual movement as a mechanism for Schistosoma mansoni transmission resurgence – a causal analysis

Lim RM, Arinaitwe M, Babayan SA, Nankasi A, Atuhaire A, Namukuta A, Nicholas M, Pedersen AB, Webster JP, Lamberton PH, Clark J.   +10 more
europepmc   +1 more source

Ethnic Disparities in Severe Maternal Morbidity and the Contribution of Deprivation: A Population-Based Causal Analysis. [PDF]

BJOG
Geddes-Barton D, Goldacre R, Knight M, Vousden N, Ramakrishnan R.   +4 more
europepmc   +1 more source