Results 51 to 60 of about 694,836 (334)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Has EU Accession Boosted Patent Performance in the EU-13? A Critical Evaluation Using Causal Impact Analysis with Bayesian Structural Time-Series Models

Forecasting, 2022
This paper provides new insights into the causal effects of the enlargement of the European Union (EU) on patent performance. The study focuses on the new EU member states (EU-13) and accession is considered as an intervention whose causal effect is ...
Agnieszka Kleszcz, Krzysztof Rusek
doaj   +1 more source

Causality fields in nonlinear causal effect analysis

Frontiers of Information Technology & Electronic Engineering, 2022
与线性因果相比, 非线性因果具有更复杂的特点和内涵. 本文主要讨论非线性因果中的若干个问题, 并着重强调因果域的概念. 本文基于广泛应用的计算模型和方法, 围绕非线性因果分析与计算以及因果域的识别问题提出相应观点和建议, 并通过几个具体案例揭示非线性因果在处理复杂因果推断问题中的重要性和现实意义.
Aiguo Wang, Li Liu, Jiaoyun Yang, Lian Li   +3 more
openaire   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies.

Lancet Neurology, 2019
BACKGROUND Genome-wide association studies (GWAS) in Parkinson's disease have increased the scope of biological knowledge about the disease over the past decade.
M. Nalls, C. Blauwendraat, C. Vallerga, K. Heilbron, S. Bandres-Ciga, Diana Chang, M. Tan, D. Kia, A. Noyce, Angli Xue, J. Bras, Emily Young, R. Coelln, J. Simón-Sánchez, C. Schulte, Manu Sharma, L. Krohn, L. Pihlstrøm, A. Siitonen, H. Iwaki, H. Leonard, F. Faghri, J. R. Gibbs, D. Hernandez, Sonja W. Scholz, J. Botía, Maria Martinez, J. Corvol, S. Lesage, J. Jankovic, L. Shulman, Margaret Sutherland, P. Tienari, K. Majamaa, M. Toft, O. Andreassen, Tushar Bangale, A. Brice, Jian Yang, Z. Gan-Or, T. Gasser, P. Heutink, J. Shulman, N. Wood, D. Hinds, J. Hardy, H. Morris, J. Gratten, P. Visscher, R. Graham, A. Singleton, A. Adarmes-Gómez, M. Aguilar, A. Aitkulova, V. Akhmetzhanov, R. Alcalay, I. Álvarez, V. Álvarez, F. Barrero, J. A. B. Yarza, I. Bernal‐Bernal, Kimberley J. Billingsley, M. Blázquez, Marta Bonilla‐Toribio, J. Botía, M. Boungiorno, K. Brockmann, V. Bubb, D. Buiza‐Rueda, A. Cámara, F. Carrillo, M. Carrión-Claro, D. Cerdán, V. Chelban, J. Clarimón, C. Clarke, Y. Compta, M. Cookson, D. Craig, F. Danjou, M. Diez-Fairen, O. Dols-Icardo, J. Duarte, R. Durán, F. Escamilla-Sevilla, V. Escott-Price, M. Ezquerra, C. Feliz, M. Fernández, R. Fernández-Santiago, S. Finkbeiner, T. Foltynie, C. García, P. Garcia-Ruiz, M. G. Heredia, P. Gómez-Garre, M. González, I. González‐Aramburu, S. Guelfi, R. Guerreiro, J. Hardy, S. Hassin-Baer, J. Hoenicka, P. Holmans, H. Houlden, J. Infante, S. Jesús, A. Jiménez-Escrig, Gulnaz Kaishybayeva, R. Kaiyrzhanov, A. Karimova, K. J. Kinghorn, S. Kõks, J. Kulisevsky, M. Labrador-Espinosa, H. Leonard, P. Lewis, J. López-Sendón, R. Lovering, S. Lubbe, C. Lungu, D. Macias, C. Manzoni, J. Marín, J. Marinus, M. Marti, I. M. Torres, J. Martínez-Castrillo, M. Mata, N. Mencacci, C. Méndez-del-Barrio, B. Middlehurst, A. Mínguez, P. Mir, K. Mok, E. Muñoz, Derek P. Narendra, O. Ojo, N. Okubadejo, A. Pagola, P. Pastor, F. Errazquin, T. Periñán-Tocino, L. Pihlstrøm, H. Plun-Favreau, J. Quinn, L. R'bibo, X. Reed, E. Rezola, M. Rizig, P. Rizzu, L. Robak, A. S. Rodriguez, G. Rouleau, J. Ruiz‐Martinez, C. Ruz, M. Ryten, D. Sadykova, S. Schreglmann, C. Shashkin, M. Sierra, E. Suárez-Sanmartin, P. Taba, C. Tabernero, Manuela Tan, J. P. Tartari, C. Tejera-Parrado, E. Tolosa, D. Trabzuni, F. Valldeoriola, J. J. Hilten, K. Keuren-Jensen, L. Vargas‐González, L. Vela, F. Vives, N. Williams, N. Zharkinbekova, Zharkyn Zharmukhanov, Elena Zholdybayeva, A. Zimprich, P. Ylikotila, L. Shulman, S. Reich, J. Savitt, M. Agee, B. Alipanahi, A. Auton, R. Bell, K. Bryc, S. Elson, P. Fontanillas, N. Furlotte, K. Huber, B. Hicks, E. Jewett, Yunxuan Jiang, A. Kleinman, Keng-Han Lin, N. Litterman, J. McCreight, M. McIntyre, K. McManus, J. Mountain, E. Noblin, C. Northover, S. Pitts, G. D. Poznik, J. Sathirapongsasuti, J. Shelton, S. Shringarpure, C. Tian, J. Tung, V. Vacic, Xin Wang, C. Wilson, Tim Anderson, Steven R Bentley, J. Dalrymple-Alford, Javed Fowdar, G. Halliday, A. Henders, I. Hickie, Irfahan Kassam, Martin Kennedy, John W Kwok, S. Lewis, G. Mellick, Grant Montgomery, J. Pearson, Toni L. Pitcher, J. Sidorenko, P. Silburn, C. Vallerga, P. Visscher, L. Wallace, N. Wray, Futao Zhang   +236 more
semanticscholar   +1 more source

Causal link between hypothyroidism and gastric cancer risk: insights gained through multivariable Mendelian randomization and mediation analysis

Frontiers in Endocrinology
BackgroundGastric cancer (GC) is the third leading cause of cancer death worldwide, and hypothyroidism has been identified as a potential influencing factor.
Tianyue Zhang, Jie Qiao, Yuanyou Wang, Yinying Zhou, Hammza Jabbar Abdl Sattar Hamoudi, Mhd Alaa Al Hendi, Jun Wang   +6 more
doaj   +1 more source

Phenome-wide Mendelian randomisation analysis identifies causal factors for age-related macular degeneration [PDF]

, 2022
Thomas Julian, Johnathan Cooper‐Knock, Stuart MacGregor, Hui Guo, Tariq Aslam, Eleanor Sanderson, Graeme C. Black, Panagiotis I. Sergouniotis   +7 more
openalex   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Probabilistic Analysis of Basic Causes of Vessel–Platform Allision Accidents

Journal of Marine Science and Engineering
This paper proposes a methodology to estimate the probability of basic causes of allision accidents between vessels and offshore platforms that overcomes the problem of data scarcity required for causal analysis.
Utkarsh Bhardwaj, Angelo Palos Teixeira, C. Guedes Soares   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source