Results 61 to 70 of about 694,836 (334)
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Frontiers in PharmacologyBackgroundStatins, which are medications that lower lipid levels, are extensively used to decrease cardiovascular disease risk. Recently, the use of statins in cancer prevention has attracted considerable interest.
Rongkang Li +10 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Causal analysis, Correlation-Response, and Dynamic cavity [PDF]
, 2015 The purpose of this note is to point out analogies between causal analysis in statistics and the correlation-response theory in statistical physics. It is further shown that for some systems the dynamic cavity offers a way to compute the stationary state
E. Aurell, G. Ferraro
semanticscholar +1 more source
Zhongguo dizhi zaihai yu fangzhi xuebaoExtreme rainfall is often accompanied by mass geological disasters, which seriously endangers the safety of people 's lives and property in prone areas and affects the healthy development of the economy and society.
Yun NAN +6 more
doaj +1 more source
Causal mediation analysis: From simple to more robust strategies for estimation of marginal natural (in)direct effects [PDF]
, 2021 Trang Quynh Nguyen +6 more
openalex +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Applied SciencesPavement performance prediction serves as a core basis for maintenance decision-making. Although numerous studies have been conducted, most focus on road segments and aggregate indicators such as IRI and PCI, with limited attention to the daily ...
Yifan Sun, Qian Gao, Feng Li, Yuchuan Du
doaj +1 more source
A Sensitivity Analysis Approach for the Causal Hazard Ratio in Randomized and Observational Studies [PDF]
, 2022 Rachel Axelrod, Daniel Nevo
openalex +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source