Results 51 to 60 of about 23,465 (251)
The Incoherent Root of Theological Fatalism
TheoLogicaThis paper begins with a standard argument for theological fatalism and unravels deeper dilemmas in stages, arriving at an argument that has nothing to do with divine foreknowledge or free will. I then focus on the problem of the incoherence or at least
Linda Zagzebski
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The Causal Efficacy of Consciousness
Entropy, 2020 Mental causation is vitally important to the integrated information theory (IIT), which says consciousness exists since it is causally efficacious.
Matthew Owen
doaj +1 more source
, 2007 We present a model of causality which is defined by the intersection of two distinct closure systems, ${cal I}$ and ${cal T}$. Next we present empirical evidence to demonstrate that this model has practical validity by examining computer trace data to reveal causal dependencies between individual code modules.
openaire +3 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
The Concept of Free Will as an Infinite Metatheoretic Recursion [PDF]
Interdisciplinary Description of Complex Systems, 2015 It is argued that the concept of free will, like the concept of truth in formal languages, requires a separation between an object level and a meta-level for being consistently defined.
Hashim Hanaan, Srikanth Radhakrishna
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Active Doings and the Principle of the Causal Closure of the Physical World
Organon F, 2019 Some philosophers hold that it would be impossible for us to do something actively if the physical world were causally closed, i.e., if in the physical world all events were caused by other physical events if they are caused at all.
Ansgar Beckermann
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source