Results 91 to 100 of about 1,819,138 (329)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
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The causal manipulation of chain event graphs [PDF]
, 2007 Discrete Bayesian Networks (BN’s) have been very successful as a framework both for inference and for expressing certain causal hypotheses. In this paper we present a class of graphical models called the chain event graph (CEG) models, that ...
Riccomagno, Eva, Smith, J. Q.
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Bivariate Causal Discovery and Its Applications to Gene Expression and Imaging Data Analysis
Frontiers in Genetics, 2018 The mainstream of research in genetics, epigenetics, and imaging data analysis focuses on statistical association or exploring statistical dependence between variables.
Rong Jiao +6 more
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CoRR, 2013 Appears in Proceedings of the Seventeenth Conference on Uncertainty in Artificial Intelligence (UAI2001)
Jin Tian 0001, Judea Pearl
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
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Beyond Covariation: Cues to Causal Structure
, 2010 Causal induction has two components: learning about the structure of causal models and learning about causal strength and other quantitative parameters. This chapter argues for several interconnected theses.
Hagmaye, Y +3 more
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Causal Graphs for EPR Experiments [PDF]
, 2013 We examine possible causal structures of experiments with entangled quantum objects. Previously, these structures have been obscured (i) by assuming a misleading probabilistic analysis of quantum non locality as 'Outcome Dependence or Parameter ...
Näger, Paul M +2 more
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Imperfect gold standard gene sets yield inaccurate evaluation of causal gene identification methods
Communications BiologyCausal gene discovery methods are often evaluated using reference sets of causal genes, which are treated as gold standards (GS) for the purposes of evaluation.
Lijia Wang, Xiaoquan Wen, Jean Morrison
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CoRREnes The proposed architecture is a mixture of experts, which allows for the model entities, such as the causal relationships, to be further parameterized. More specifically, an attempt is made to exploit a neural net as implementing neurons poses a great challenge for this dataset. To explain, a simple and fast Pearson coefficient linear model usually
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
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