Results 71 to 80 of about 477,715 (269)

Bivariate Causal Discovery and Its Applications to Gene Expression and Imaging Data Analysis

Frontiers in Genetics, 2018
The mainstream of research in genetics, epigenetics, and imaging data analysis focuses on statistical association or exploring statistical dependence between variables.
Rong Jiao, Nan Lin, Zixin Hu, David A. Bennett, Li Jin, Li Jin, Momiao Xiong   +6 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Multi-Dimensional Causal Discovery [PDF]

, 2013
We propose a method for learning causal relations within high-dimensional tensor data as they are typically recorded in non-experimental databases. The method allows the simultaneous inclusion of numerous dimensions within the data analysis such as ...
Kostas Stathis, Royal Holloway, Stefano Bromuri, Ulrich Schaechtle   +3 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Imperfect gold standard gene sets yield inaccurate evaluation of causal gene identification methods

Communications Biology
Causal gene discovery methods are often evaluated using reference sets of causal genes, which are treated as gold standards (GS) for the purposes of evaluation.
Lijia Wang, Xiaoquan Wen, Jean Morrison
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Argumentative Causal Discovery

Proceedings of the TwentyFirst International Conference on Principles of Knowledge Representation and Reasoning
Causal discovery amounts to unearthing causal relationships amongst features in data. It is a crucial companion to causal inference, necessary to build scientific knowledge without resorting to expensive or impossible randomised control trials.
Russo, Fabrizio, Rapberger, Anna, Toni, Francesca   +2 more
openaire   +2 more sources

Causality, Causal Discovery, and Causal Inference in Structural Engineering

, 2022
Much of our experiments are designed to uncover the cause(s) and effect(s) behind a data generating mechanism (i.e., phenomenon) we happen to be interested in. Uncovering such relationships allows us to identify the true working of a phenomenon and, most importantly, articulate a model that may enable us to further explore the phenomenon on hand and/or
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source