Results 181 to 190 of about 1,964,226 (308)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

How do mass shootings shape the social media discourse on guns in the US Congress? Causal discovery and topic modeling. [PDF]

PLOS Glob Public Health
Bukhanevych D, Succar R, Porfiri M.
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Large-scale causal discovery using interventional data sheds light on gene network structure in k562 cells. [PDF]

Nat Commun
Brown BC, Tokolyi A, Morris JA, Lappalainen T, Knowles DA.   +4 more
europepmc   +1 more source

Aristotle: stratified causal discovery for omics data. [PDF]

BMC Bioinformatics, 2022
Mansouri M, Khakabimamaghani S, Chindelevitch L, Ester M.   +3 more
europepmc   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Exploring Causal Pathways to Sleep Quality in Young Adults Using a Multimodal Data-Driven Causal Discovery Analysis. [PDF]

Nat Sci Sleep
Xiao X, Wang Y, Dong D, Wang W, Li Z, Guo Y.   +5 more
europepmc   +1 more source

Causal discovery replicates symptomatic and functional interrelations of posttraumatic stress across five patient populations. [PDF]

Front Psychiatry, 2022
Pierce B, Kirsh T, Ferguson AR, Neylan TC, Ma S, Kummerfeld E, Cohen BE, Nielson JL.   +7 more
europepmc   +1 more source

Contexts of Causal Discovery

, 2012
I distinguish two notions of the “context of discovery”. The traditional notion opposes it to the context of justification but another, more recent, notion relates it to the methodology of causal inference. Reichenbach himself seems to have subscribed the more recent notion and, not surprisingly, his contribution to the field of causal discovery has ...
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source