Results 181 to 190 of about 16,076,570 (308)

Investigating the Causal Effect of Potential Therapeutic Agents for Colorectal Cancer Prevention: A Mendelian Randomization Analysis. [PDF]

Cancer Epidemiol Biomarkers Prev
Fryer E, Bishop DT, Campbell PT, Chan AT, Le Marchand L, Li CI, Moreno V, Gunter MJ, Phipps AI, Grant RC, Schmit SL, Martin RM, Yarmolinsky J, Haycock P.   +13 more
europepmc   +1 more source

Causal effect questioned

American Journal of Obstetrics and Gynecology, 1990
openaire   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Assessment of the causal effect of lifestyle factors on postoperative infections based on Mendelian randomization. [PDF]

Medicine (Baltimore)
Fu WJ, Ni XX, Yang H, Lian W, Xu F.
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Commentary: Estimating causal effects [PDF]

International Journal of Epidemiology, 2002
Jay S Kaufman, Sol Kaufman
openaire   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Estimating the causal effect of cardiometabolic conditions on socioeconomic and healthcare outcomes: a scoping review of Mendelian randomization studies. [PDF]

Health Econ Rev
Pedron S, Tan X, Maushagen J, Stephan AJ, Burns J, Sanderson E, Wade K, Laxy M.   +7 more
europepmc   +1 more source

GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability

Nature Neuroscience, 2018
J. Pasman, K. Verweij, K. Verweij, Z. Gerring, S. Stringer, S. Sanchez-Roige, J. Treur, A. Abdellaoui, M. Nivard, B. Baselmans, Jue-Sheng Ong, Hill F. Ip, M. D. Zee, M. Bartels, F. Day, P. Fontanillas, S. Elson, H. Wit, L. Davis, J. Mackillop, J. Derringer, Susan J T Branje, C. Hartman, A. Heath, P. Lier, P. Madden, R. Mägi, W. Meeus, G. Montgomery, A. Oldehinkel, Z. Pausova, J. Ramos-Quiroga, T. Paus, M. Ribasés, M. Ribasés, J. Kaprio, M. Boks, J. Bell, T. Spector, J. Gelernter, D. Boomsma, N. Martin, S. Macgregor, J. Perry, A. Palmer, D. Posthuma, M. Munafo, Nathan A. Gillespie, Nathan A. Gillespie, E. Derks, J. Vink   +50 more
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source