Results 201 to 210 of about 687,701 (312)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Causal effect of urinary sodium-to-creatinine ratio on gastrointestinal diseases: A two-sample Mendelian randomization study. [PDF]

Medicine (Baltimore)
Jiang Y, Zhang Z, Ding Y, Xu S, Chen R, Zheng Z, Bao M, He B, Li S.   +8 more
europepmc   +1 more source

Estimating the Bayesian posterior distribution of indirect effects in causal longitudinal mediation analysis

Many research studies aim to unveil the causal mechanism underlying a particular phenomenon; mediation analysis is increasingly used for this scope, and longitudinal data are particularly suited for mediation since they ensure the correct temporal order ...
Abbruzzo, Antonino, Di Maria, Chiara, Lovison, Gianfranco   +2 more
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Marginal causal effect of fungicide seed treatments on soybean yield and uncertain profitability in the US Midwest. [PDF]

Sci Rep
Esker PD, Shah DA, Mourtzinis S, Grassini P, Silva TS, Conley SP.   +5 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Assessing the causal effect of tobacco retail density on cardiovascular and pulmonary disease hospitalizations in the United States. [PDF]

Prev Med Rep
Baggett CD, Kuo TM, Zivich PN, Rudolph JE, Ribisl KM, Golden SD.   +5 more
europepmc   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Exploring the causal effect of genetically predicted blood and cerebrospinal fluid metabolites and metabolic pathways on intracranial aneurysm. [PDF]

J Int Med Res
Ding L, Cao W, Zhou Z, Mei Z, Chen B, Lu X, Chen W.   +6 more
europepmc   +1 more source

Causal Inference in Comparative and International Education

All phenomena in the social sciences are shaped by a complex web of variables, and using data to detect patterns and trends in such variables is important.
Kameshwara, K., Gorman, E.
core