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Genome-wide association studies [PDF]
Nature Reviews Methods Primers, 2021 Genome- wide association studies (GWAS) test hundreds of thousands of genetic variants across many genomes to find those statistically associated with a specific trait or disease. This methodology has generated a myriad of robust associations for a range of traits and diseases, and the number of associated variants is expected to grow steadily as GWAS ...
E. Uffelmann +8 more
semanticscholar +8 more sources
Chapter 11: Genome-wide association studies.
PLoS Computational Biology, 2012 Genome-wide association studies (GWAS) have evolved over the last ten years into a powerful tool for investigating the genetic architecture of human disease.
William S Bush, Jason H Moore
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Guidelines for genome-wide association studies. [PDF]
PLoS Genetics, 2012 Genome-wide association studies (GWAS) have revolutionized human genetics. They have led to the identification of thousands of loci that affect both normal variation and susceptibility to disease, and have clarified our understanding of the genetic architecture of complex traits.
Gregory S Barsh +3 more
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Replication in Genome-Wide Association Studies
Statistical Science, 2010 Replication helps ensure that a genotype-phenotype association observed in a genome-wide association (GWA) study represents a credible association and is not a chance finding or an artifact due to uncontrolled biases.
Ioannidis, John P. A. +2 more
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Status and prospects of genome‐wide association studies in plants
The Plant Genome, 2021 Genome‐wide association studies (GWAS) have developed into a powerful and ubiquitous tool for the investigation of complex traits. In large part, this was fueled by advances in genomic technology, enabling us to examine genome‐wide genetic variants ...
Laura Tibbs Cortes +2 more
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Genome-Wide Association Studies of Asthma
Allergology International, 2011 Bronchial asthma is a common inflammatory disease caused by a combination of genetic and environmental factors. To discover the genes and cellular pathways underlying asthma, a large number of genetic studies have been conducted.
Mayumi Tamari +2 more
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‘Next-generation’ genome wide association studies [PDF]
Hereditary Cancer in Clinical Practice, 2012 Hopper J +8 more
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Genome-Wide Association Study on Longitudinal Change in Fasting Plasma Glucose in Korean Population [PDF]
Diabetes & Metabolism Journal, 2023 Background Genome-wide association studies (GWAS) on type 2 diabetes mellitus (T2DM) have identified more than 400 distinct genetic loci associated with diabetes and nearly 120 loci for fasting plasma glucose (FPG) and fasting insulin level to date ...
Heejin Jin +6 more
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Genome-Wide Association Study Identifies Loci Associated with Sensitive Skin
Cosmetics, 2020 Individuals suffering from sensitive skin often have other skin conditions and/or diseases, such as fair skin, freckles, rosacea, or atopic dermatitis. Genome-wide association studies (GWAS) have been performed for some of these conditions, but not for ...
Miranda A. Farage +4 more
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Genome-Wide Association Studies in Atherosclerosis [PDF]
Current Atherosclerosis Reports, 2011 Cardiovascular disease remains the major cause of worldwide morbidity and mortality. Its pathophysiology is complex and multifactorial. Because the phenotype of cardiovascular disease often shows a marked heritable pattern, it is likely that genetic factors play an important role.
Sivapalaratnam, S. +7 more
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