Results 41 to 50 of about 1,107,991 (320)

Meta-analysis of genome-wide association studies for height and body mass index in ∼700,000 individuals of European ancestry

bioRxiv, 2018
Genome-wide association studies (GWAS) stand as powerful experimental designs for identifying DNA variants associated with complex traits and diseases. In the past decade, both the number of such studies and their sample sizes have increased dramatically.
L. Yengo, J. Sidorenko, K. Kemper, Zhili Zheng, A. Wood, M. Weedon, T. Frayling, J. Hirschhorn, Jian Yang, P. Visscher   +9 more
semanticscholar   +1 more source

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies.

Lancet Neurology, 2019
BACKGROUND Genome-wide association studies (GWAS) in Parkinson's disease have increased the scope of biological knowledge about the disease over the past decade.
M. Nalls, C. Blauwendraat, C. Vallerga, K. Heilbron, S. Bandres-Ciga, Diana Chang, M. Tan, D. Kia, A. Noyce, Angli Xue, J. Bras, Emily Young, R. Coelln, J. Simón-Sánchez, C. Schulte, Manu Sharma, L. Krohn, L. Pihlstrøm, A. Siitonen, H. Iwaki, H. Leonard, F. Faghri, J. R. Gibbs, D. Hernandez, Sonja W. Scholz, J. Botía, Maria Martinez, J. Corvol, S. Lesage, J. Jankovic, L. Shulman, Margaret Sutherland, P. Tienari, K. Majamaa, M. Toft, O. Andreassen, Tushar Bangale, A. Brice, Jian Yang, Z. Gan‐Or, T. Gasser, P. Heutink, J. Shulman, N. Wood, D. Hinds, J. Hardy, H. Morris, J. Gratten, P. Visscher, R. Graham, A. Singleton, A. Adarmes-Gómez, M. Aguilar, A. Aitkulova, Vadim Akhmetzhanov, R. Alcalay, I. Álvarez, V. Álvarez, F. Barrero, J. A. B. Yarza, I. Bernal‐Bernal, Kimberley J. Billingsley, M. Blázquez, Marta Bonilla‐Toribio, J. Botía, M. Boungiorno, K. Brockmann, V. Bubb, D. Buiza‐Rueda, A. Cámara, F. Carrillo, M. Carrión-Claro, D. Cerdán, V. Chelban, J. Clarimón, C. Clarke, Y. Compta, M. Cookson, D. Craig, F. Danjou, M. Diez-Fairen, O. Dols-Icardo, J. Duarte, R. Durán, F. Escamilla-Sevilla, V. Escott-Price, M. Ezquerra, C. Feliz, M. Fernández, R. Fernández-Santiago, S. Finkbeiner, T. Foltynie, C. García, P. Garcia-Ruiz, M. G. Heredia, P. Gómez-Garre, M. González, I. González‐Aramburu, S. Guelfi, R. Guerreiro, J. Hardy, S. Hassin-Baer, J. Hoenicka, P. Holmans, H. Houlden, J. Infante, S. Jesús, A. Jiménez-Escrig, Gulnaz Kaishybayeva, R. Kaiyrzhanov, A. Karimova, K. J. Kinghorn, S. Kõks, J. Kulisevsky, M. Labrador-Espinosa, H. Leonard, P. Lewis, J. López-Sendón, R. Lovering, S. Lubbe, C. Lungu, D. Macias, C. Manzoni, J. Marín, J. Marinus, M. Marti, I. M. Torres, J. Martínez-Castrillo, M. Mata, N. Mencacci, C. Méndez-del-Barrio, B. Middlehurst, A. Mínguez, P. Mir, K. Mok, E. Muñoz, Derek P. Narendra, O. Ojo, N. Okubadejo, A. Pagola, P. Pastor, F. Errazquin, T. Periñán-Tocino, L. Pihlstrøm, H. Plun-Favreau, J. Quinn, L. R'bibo, X. Reed, E. Rezola, M. Rizig, P. Rizzu, L. Robak, A. Rodríguez, G. Rouleau, J. Ruiz‐Martinez, C. Ruz, M. Ryten, D. Sadykova, S. Schreglmann, C. Shashkin, M. Sierra, E. Suárez-Sanmartin, P. Taba, C. Tabernero, Manuela Tan, J. P. Tartari, C. Tejera-Parrado, E. Tolosa, D. Trabzuni, F. Valldeoriola, J. J. Hilten, K. Keuren-Jensen, L. Vargas‐González, L. Vela, F. Vives, N. Williams, N. Zharkinbekova, Zharkyn Zharmukhanov, Elena Zholdybayeva, A. Zimprich, P. Ylikotila, L. Shulman, S. Reich, J. Savitt, M. Agee, B. Alipanahi, A. Auton, R. Bell, K. Bryc, S. Elson, P. Fontanillas, N. Furlotte, K. Huber, B. Hicks, E. Jewett, Yunxuan Jiang, A. Kleinman, Keng-Han Lin, N. Litterman, J. McCreight, M. McIntyre, K. McManus, J. Mountain, E. Noblin, C. Northover, S. Pitts, G. D. Poznik, J. Sathirapongsasuti, J. Shelton, S. Shringarpure, C. Tian, J. Tung, V. Vacic, Xin Wang, C. H. Wilson, Tim Anderson, Steven R. Bentley, J. Dalrymple-Alford, Javed Fowdar, G. Halliday, A. Henders, I. Hickie, Irfahan Kassam, Martin Kennedy, John W Kwok, S. Lewis, G. Mellick, Grant Montgomery, J. Pearson, Toni L. Pitcher, J. Sidorenko, P. Silburn, C. Vallerga, P. Visscher, L. Wallace, N. Wray, Futao Zhang   +236 more
semanticscholar   +1 more source

Genome-wide association studies for Alzheimer’s disease: bigger is not always better

Brain Communications, 2022
As the size of genome-wide association studies increase, the number of associated trait loci identified inevitably increase. One welcomes this if it allows the better delineation of the pathways to disease and increases the accuracy of genetic prediction
V. Escott-Price, J. Hardy
semanticscholar   +1 more source

Simulating variance heterogeneity in quantitative genome wide association studies

BMC Bioinformatics, 2018
Background Analyzing Variance heterogeneity in genome wide association studies (vGWAS) is an emerging approach for detecting genetic loci involved in gene-gene and gene-environment interactions.
Ahmad Al Kawam, Mustafa Alshawaqfeh, James J. Cai, Erchin Serpedin, Aniruddha Datta   +4 more
doaj   +1 more source

Reporting and Interpretation in Genome-Wide Association Studies [PDF]

, 2007
In the context of genome-wide association studies we critique a number of methods that have been suggested for flagging associations for further investigation.
Wakefield, Jon
core   +5 more sources

Iterative Usage of Fixed and Random Effect Models for Powerful and Efficient Genome-Wide Association Studies

PLoS Genetics, 2016
False positives in a Genome-Wide Association Study (GWAS) can be effectively controlled by a fixed effect and random effect Mixed Linear Model (MLM) that incorporates population structure and kinship among individuals to adjust association tests on ...
Xiaolei Liu, Meng Huang, B. Fan, E. Buckler, Zhiwu Zhang   +4 more
semanticscholar   +1 more source

Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

Genome Biology, 2021
Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a ...
D. McCartney, J. Min, R. Richmond, A. Lu, M. Sobczyk, G. Davies, L. Broer, Xiuqing Guo, A. Jeong, Jeesun Jung, S. Kasela, S. Katrinli, Pei-lun Kuo, P. Matías-García, Pashupati P. Mishra, Marianne Nygaard, T. Palviainen, A. Patki, L. Raffield, S. Ratliff, T. Richardson, O. Robinson, M. Soerensen, Dianjianyi Sun, P. Tsai, M. D. Zee, R. Walker, Xiaochuan Wang, Yunzhang Wang, R. Xia, Zongli Xu, Jie Yao, Wei Zhao, A. Correa, E. Boerwinkle, P. Dugué, P. Durda, H. Elliott, C. Gieger, E. D. Geus, S. Harris, G. Hemani, M. Imboden, M. Kähönen, S. Kardia, J. Kresovich, Shengxu Li, K. Lunetta, M. Mangino, D. Mason, A. McIntosh, J. Mengel-From, A. Moore, J. Murabito, M. Ollikainen, J. Pankow, N. Pedersen, A. Peters, S. Polidoro, D. Porteous, O. Raitakari, S. Rich, D. Sandler, E. Sillanpää, Alicia K. Smith, M. Southey, K. Strauch, H. Tiwari, Toshiko Tanaka, T. Tillin, A. Uitterlinden, D. Berg, J. Dongen, James G. Wilson, John Wright, Idil Yet, D. Arnett, S. Bandinelli, J. Bell, Alexandra M. Binder, D. Boomsma, Wei Chen, K. Christensen, K. Conneely, P. Elliott, L. Ferrucci, M. Fornage, S. Hägg, C. Hayward, M. Irvin, J. Kaprio, D. Lawlor, T. Lehtimäki, F. Lohoff, L. Milani, R. Milne, N. Probst-Hensch, A. Reiner, B. Ritz, J. Rotter, Jennifer A. Smith, Jack A. Taylor, J. Meurs, P. Vineis, M. Waldenberger, I. Deary, C. Relton, S. Horvath, R. Marioni, T. I. G. Consortium, Nhlbi Trans-Omics for Precision Medicine Consortium   +110 more
semanticscholar   +1 more source

Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances [PDF]

, 2013
Twin and family studies indicate that the timing of primary tooth eruption is highly heritable, with estimates typically exceeding 80%. To identify variants involved in primary tooth eruption we performed a population based genome-wide association study ...
Alexei I. Zhurov, Anja Taanila, Anneli Pouta, Arshed M. Toma, Bakrania, Bayés de Luna, Beate St Pourcain, Bei, Bjarke Feenstra, Clive J. Hoggart, Cole, Cornelis, David M. Evans, Demetris Pillas, Di Cello, Eleftherohorinou, Eleftherohorinou, Elks, Ellen A. Nohr, Frank Geller, Freedman, Fujiwara, Geller, George Davey Smith, Ghazaleh Fatemifar, Golding, Goyal, Gu, Gudbjartsson, Hammarsund, Haraguchi, Hikake, Holmans, Horikoshi, Houlston, Hughes, Inga Prokopenko, Jernvall, Jia, John P. Kemp, Jon H. Tobias, Jussila, Kang, Kere, Kirsi Sipila, Lango Allen, Lavinia Paternoster, Levy, Li, Ligon, Mads Melbye, Marjo-Riitta Jarvelin, Meindl, Mikkola, Momoko Horikoshi, Mustonen, Nicholas J. Timpson, Nohr, Nunes, Nyholt, Paternoster, Pillas, Pispa, Pruim, Raija Lähdesmäki, Sabatti, Sakuraba, Simón-Sánchez, Soranzo, Srivastava, Stein, Stephen Richmond, Susan M. Ring, Taal, Taviaux, Tummers, Vainio, Vaz, Victoria J. Wright, Weedon, Willer, Wise, Yabe, Yang, Zhang   +84 more
core   +2 more sources

Genome-Wide Association Studies of Allergic Diseases

Allergology International, 2013
Allergic diseases are complex diseases caused by a combination of genetic and environmental factors. To determine the genetic components of these diseases and to discover the genes and cellular pathways underlying them, a large number of genetic studies ...
Mayumi Tamari, ShotaTanaka, Tomomitsu Hirota   +2 more
doaj   +1 more source

Sequencing-based genome-wide association studies reporting standards

Cell Genomics, 2021
Summary: Genome sequencing has recently become a viable genotyping technology for use in genome-wide association studies (GWASs), offering the potential to analyze a broader range of genome-wide variation, including rare variants.
Aoife McMahon, Elizabeth Lewis, Annalisa Buniello, Maria Cerezo, Peggy Hall, Elliot Sollis, Helen Parkinson, Lucia A. Hindorff, Laura W. Harris, Jacqueline A.L. MacArthur   +9 more
doaj   +1 more source