Results 41 to 50 of about 430,711 (260)

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

Genome-wide association studies and the genetics of entrepreneurship [PDF]

European Journal of Epidemiology, 2010
Entrepreneurship is a vital element of well-functioning economies. It is sometimes denoted as their ‘scarcest input factor’. Entrepreneurs introduce innovations into the economic system and may contribute towards higher productivity levels and hence economic growth [1, 2, 3].
van der Loos, M.J.H.M., Koellinger, Ph.D., Groenen, P.J.F., Thurik, A.R.   +3 more
openaire   +7 more sources

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

Genome Wide Association Studies Using Multiple-lactation Breeding Value in Holsteins [PDF]

Asian-Australasian Journal of Animal Sciences, 2015
A genome wide association study was conducted using estimated breeding value (EBV) for milk production traits from 1st to 4th lactation. Significant single nucleotide polymorphism (SNP) markers were selected for each trait and the differences were ...
Kwang-Hyun Cho, Jae-Don Oh, Hee-bal Kim, Kyung-Do Park, Joon-Ho Lee   +4 more
doaj   +1 more source

Clinical, Histopathological, and Molecular Characterization of Pediatric MN1::ZNF341‐Associated Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A lethal round‐cell malignancy with an MN1::ZNF341 fusion has recently been reported in three infants. Here, we describe four further tumors, three in newborns (including monozygotic twins), and one in an adolescent. Detailed clinical, radiological, and histopathological data differentiate these tumors from their main mimics, neuroblastoma and
Thomas R. W. Oliver, Dyanne Rampling, Barbara Walkowiak, Nathaniel D. Anderson, Manas Dave, Henry Lee‐Six, Sadie Baskind, Pooja Balasubramanian, Glenn Anderson, Conor Parks, Toochi Ogbonnah, Emilia R. Robertson, Simon Hannam, Rohan Verma, John C. Achermann, Liina Palm, Neil Sebire, Thomas Jacques, Tom Watson, Carryl Dryden, Karin Straathof, Mette Jorgensen, Olga Slater, Sam Behjati, Sarita Depani, J. Ciaran Hutchinson   +25 more
wiley   +1 more source

ICAM-1 molecular mechanism and genome wide SNP's association studies

Indian Heart Journal, 2015
Macrophages transformed foam cell formation occurs as a result of leukocyte accumulation mediated through intercellular adhesion molecule 1 (ICAM1), vascular cell adhesion molecule 1 (VCAM1), and E-selectin, secreted by inflamed or damaged endothelium ...
C. Anbarasan, M. Bavanilatha, K. Latchumanadhas, S. Ajit Mullasari   +3 more
doaj   +1 more source

Admixture Mapping Reveals Candidate Regions for Methotrexate Neurotoxicity Susceptibility: A Reducing Disparities in Acute Leukemia Consortium Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris, Priya B. Shetty, Olga A. Taylor, Elizabeth G. Atkinson, Melissa A. Richard, M. Monica Gramatges, Mark Zobeck, Sandi Pruitt, Amy Hughes, M. Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Han Chen, Bing Yu, Philip J. Lupo, Karen R. Rabin, Michael E. Scheurer, Austin L. Brown, The REDIAL Consortium   +24 more
wiley   +1 more source

A genome-wide association study of aging

Neurobiology of Aging, 2011
Human longevity and healthy aging show moderate heritability (20%-50%). We conducted a meta-analysis of genome-wide association studies from 9 studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium for 2 outcomes: (1) all-cause mortality, and (2) survival free of major disease or death.
Walter, Stefan, Atzmon, Gil, Völker, Uwe, Yu, Lei, Arnold, Alice, Benjamin, Emelia J, Biffar, Reiner, Buchman, Aron S, Boerwinkle, Eric, Couper, David, De Jager, Philip L, Evans, Denis A, Demerath, Ellen W, Harris, Tamara B, Hoffmann, Wolfgang, Hofman, Albert, Karasik, David, Kiel, Douglas P, Kocher, Thomas, Kuningas, Maris, Launer, Lenore J, Lohman, Kurt K, Lutsey, Pamela L, Garcia, Melissa E, Mackenbach, Johan, Marciante, Kristin, Psaty, Bruce M, Reiman, Eric M, Rotter, Jerome I, Seshadri, Sudha, Shardell, Michelle D, Smith, Albert V, van Duijn, Cornelia, Walston, Jeremy, Kaplan, Robert C, Zillikens, M Carola, Bandinelli, Stefania, Baumeister, Sebastian E, Bennett, David A, Ferrucci, Luigi, Gudnason, Vilmundur, Kivimaki, Mika, Liu, Yongmei, Murabito, Joanne M, Newman, Anne B, Kumari, Meena, Tiemeier, Henning, Franceschini, Nora, Lunetta, Kathryn L, Milaneschi, Yuri, Tanaka, Toshiko, Tranah, Gregory J   +51 more
openaire   +3 more sources

Power analysis for genome-wide association studies

BMC Genetics, 2007
Background Genome-wide association studies are a promising new tool for deciphering the genetics of complex diseases. To choose the proper sample size and genotyping platform for such studies, power calculations that take into account genetic model, tag ...
Klein Robert J
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source