Results 41 to 50 of about 450,356 (259)

Sequencing-based genome-wide association studies reporting standards

Cell Genomics, 2021
Summary: Genome sequencing has recently become a viable genotyping technology for use in genome-wide association studies (GWASs), offering the potential to analyze a broader range of genome-wide variation, including rare variants.
Aoife McMahon, Elizabeth Lewis, Annalisa Buniello, Maria Cerezo, Peggy Hall, Elliot Sollis, Helen Parkinson, Lucia A. Hindorff, Laura W. Harris, Jacqueline A.L. MacArthur   +9 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Genome-wide association studies and the genetics of entrepreneurship [PDF]

European Journal of Epidemiology, 2010
Entrepreneurship is a vital element of well-functioning economies. It is sometimes denoted as their ‘scarcest input factor’. Entrepreneurs introduce innovations into the economic system and may contribute towards higher productivity levels and hence economic growth [1, 2, 3].
van der Loos, M.J.H.M., Koellinger, Ph.D., Groenen, P.J.F., Thurik, A.R.   +3 more
openaire   +7 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

ICAM-1 molecular mechanism and genome wide SNP's association studies

Indian Heart Journal, 2015
Macrophages transformed foam cell formation occurs as a result of leukocyte accumulation mediated through intercellular adhesion molecule 1 (ICAM1), vascular cell adhesion molecule 1 (VCAM1), and E-selectin, secreted by inflamed or damaged endothelium ...
C. Anbarasan, M. Bavanilatha, K. Latchumanadhas, S. Ajit Mullasari   +3 more
doaj   +1 more source

Identification of Novel Genetic Variants Related to Trabecular Bone Score in Community-Dwelling Older Adults [PDF]

Endocrinology and Metabolism, 2020
Background As the genetic variants of trabecular bone microarchitecture are not well-understood, we performed a genome-wide association study to identify genetic determinants of bone microarchitecture analyzed by trabecular bone score (TBS).
Sung Hye Kong, Ji Won Yoon, Jung Hee Kim, JooYong Park, Jiyeob Choi, Ji Hyun Lee, A Ram Hong, Nam H. Cho, Chan Soo Shin   +8 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A genome-wide association study of aging

Neurobiology of Aging, 2011
Human longevity and healthy aging show moderate heritability (20%-50%). We conducted a meta-analysis of genome-wide association studies from 9 studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium for 2 outcomes: (1) all-cause mortality, and (2) survival free of major disease or death.
Walter, Stefan, Atzmon, Gil, Völker, Uwe, Yu, Lei, Arnold, Alice, Benjamin, Emelia J, Biffar, Reiner, Buchman, Aron S, Boerwinkle, Eric, Couper, David, De Jager, Philip L, Evans, Denis A, Demerath, Ellen W, Harris, Tamara B, Hoffmann, Wolfgang, Hofman, Albert, Karasik, David, Kiel, Douglas P, Kocher, Thomas, Kuningas, Maris, Launer, Lenore J, Lohman, Kurt K, Lutsey, Pamela L, Garcia, Melissa E, Mackenbach, Johan, Marciante, Kristin, Psaty, Bruce M, Reiman, Eric M, Rotter, Jerome I, Seshadri, Sudha, Shardell, Michelle D, Smith, Albert V, van Duijn, Cornelia, Walston, Jeremy, Kaplan, Robert C, Zillikens, M Carola, Bandinelli, Stefania, Baumeister, Sebastian E, Bennett, David A, Ferrucci, Luigi, Gudnason, Vilmundur, Kivimaki, Mika, Liu, Yongmei, Murabito, Joanne M, Newman, Anne B, Kumari, Meena, Tiemeier, Henning, Franceschini, Nora, Lunetta, Kathryn L, Milaneschi, Yuri, Tanaka, Toshiko, Tranah, Gregory J   +51 more
openaire   +3 more sources

Power analysis for genome-wide association studies

BMC Genetics, 2007
Background Genome-wide association studies are a promising new tool for deciphering the genetics of complex diseases. To choose the proper sample size and genotyping platform for such studies, power calculations that take into account genetic model, tag ...
Klein Robert J
doaj   +1 more source