Results 61 to 70 of about 22,469,227 (260)

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

The Human Microbiome and the Missing Heritability Problem

open access: yesFrontiers in Genetics, 2017
The “missing heritability” problem states that genetic variants in Genome-Wide Association Studies (GWAS) cannot completely explain the heritability of complex traits.
Santiago Sandoval-Motta   +6 more
doaj   +1 more source

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure [PDF]

open access: yes, 2011
Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans1, 2, 3. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N =
Döring, Angela   +999 more
core   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Identification of novel drug targets for multiple sclerosis by integrating plasma genetics and proteomes

open access: yesExperimental Gerontology
Background: Genome-wide association studies (GWAS) have revealed numerous loci associated with multiple sclerosis (MS). However, the challenge lies in deciphering the mechanisms by which these loci influence the target traits.
Yi Liu   +7 more
doaj   +1 more source

Improved heritability estimation from genome-wide SNPs [PDF]

open access: yes, 2012
Narrow-sense heritability (h(2)) is an important genetic parameter that quantifies the proportion of phenotypic variance in a trait attributable to the additive genetic variation generated by all causal variants.
Johnson, Michael R.   +7 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Gene-centric characteristics of genome-wide association studies. [PDF]

open access: yesPLoS ONE, 2007
BACKGROUND: The high-throughput genotyping chips have contributed greatly to genome-wide association (GWA) studies to identify novel disease susceptibility single nucleotide polymorphisms (SNPs).
Changzheng Dong   +5 more
doaj   +1 more source

Genome-wide association study of behavioural and psychiatric features in human prion disease. [PDF]

open access: yes, 2015
Prion diseases are rare neurodegenerative conditions causing highly variable clinical syndromes, which often include prominent neuropsychiatric symptoms.
Carswell, C   +9 more
core  

Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution [PDF]

open access: yes, 2009
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist–hip ratio (WHR). We selected 26 SNPs
Boehnke, M.   +999 more
core   +1 more source

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