Results 61 to 70 of about 450,356 (259)

Identification of novel drug targets for multiple sclerosis by integrating plasma genetics and proteomes

Experimental Gerontology
Background: Genome-wide association studies (GWAS) have revealed numerous loci associated with multiple sclerosis (MS). However, the challenge lies in deciphering the mechanisms by which these loci influence the target traits.
Yi Liu, Qian Wang, Yuhui Zhao, Liu Liu, Jingxi Hu, Yao Qiao, Jinyi Chen, Chao Qin   +7 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Genome-Wide Association Studies and Beyond [PDF]

Annual Review of Public Health, 2010
Genome-wide association studies (GWAS) provide an important avenue for undertaking an agnostic evaluation of the association between common genetic variants and risk of disease. Recent advances in our understanding of human genetic variation and the technology to measure such variation have made GWAS feasible.
openaire   +2 more sources

Gene-centric characteristics of genome-wide association studies. [PDF]

PLoS ONE, 2007
BACKGROUND: The high-throughput genotyping chips have contributed greatly to genome-wide association (GWA) studies to identify novel disease susceptibility single nucleotide polymorphisms (SNPs).
Changzheng Dong, Ziliang Qian, Peilin Jia, Ying Wang, Wei Huang, Yixue Li   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Meta-Analysis in Genome-Wide Association Studies [PDF]

Pharmacogenomics, 2009
The advent of genome-wide association studies has allowed considerable progress in the identification and robust replication of common gene variants that confer susceptibility to common diseases and other phenotypes of interest. These genetic effect sizes are almost invariably moderate to small in magnitude and single studies, even if large, are ...
Zeggini, E., Ioannidis, J. P.
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Novel candidate plasma proteins for the pathogenesis and treatment of atopic dermatitis revealed by proteome-wide association study

Scientific Reports
Atopic dermatitis (AD) is an immune-related skin disease with a genetic background. Numerous loci have been identified associated with AD to better comprehend its complicated genetic mechanisms by genome‑wide association studies (GWASs). However, current
Chen Luo, YaJing Zhang, QiFan Feng, KaiXin Yao, LeiLei Zheng, Ye Yang, WenXin Zheng, Feng Li, YongQiang Lv, Yue Cai   +9 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Genome-Wide Association Study of Vascular Dementia [PDF]

Stroke, 2012
Background and Purpose— Most studies investigating the genetics of dementia have focused on Alzheimer disease, but little is known about the genetics of vascular dementia. The aim of our study was to identify new loci associated with vascular dementia. Methods— We performed a genome-
Schrijvers, Elisabeth M.C., Schürmann, Britta, Koudstaal, Peter J., Van Den Bussche, Hendrik, Van Duijn, Cornelia M., Hentschel, Frank, Heun, Reinhard, Hofman, Albert, Jessen, Frank, Kölsch, Heike, Kornhuber, Johannes, Peters, Oliver, Rivadeneira, Fernando, Rüther, Eckart, Uitterlinden, André G., Riedel-Heller, Steffi, Dichgans, Martin, Wiltfang, Jens, Maier, Wolfgang, Breteler, Monique M.B., Ikram, M. Arfan   +20 more
openaire   +5 more sources