ICAM-1 molecular mechanism and genome wide SNP's association studies
Indian Heart Journal, 2015 Macrophages transformed foam cell formation occurs as a result of leukocyte accumulation mediated through intercellular adhesion molecule 1 (ICAM1), vascular cell adhesion molecule 1 (VCAM1), and E-selectin, secreted by inflamed or damaged endothelium ...
C. Anbarasan +3 more
doaj +1 more source
Rapid scoring of genes in microbial pan-genome-wide association studies with Scoary
Genome Biology, 2016 Genome-wide association studies (GWAS) have become indispensable in human medicine and genomics, but very few have been carried out on bacteria. Here we introduce Scoary, an ultra-fast, easy-to-use, and widely applicable software tool that scores the ...
O. Brynildsrud +3 more
semanticscholar +1 more source
Genome-wide association studies: a primer [PDF]
Psychological Medicine, 2009 There have been nearly 400 genome-wide association studies (GWAS) published since 2005. The GWAS approach has been exceptionally successful in identifying common genetic variants that predispose to a variety of complex human diseases and biochemical and anthropometric traits. Although this approach is relatively new, there are many excellent reviews of
Corvin, A. +2 more
openaire +4 more sources
Power analysis for genome-wide association studies
BMC Genetics, 2007 Background Genome-wide association studies are a promising new tool for deciphering the genetics of complex diseases. To choose the proper sample size and genotyping platform for such studies, power calculations that take into account genetic model, tag ...
Klein Robert J
doaj +1 more source
Identification of Novel Genetic Variants Related to Trabecular Bone Score in Community-Dwelling Older Adults [PDF]
Endocrinology and Metabolism, 2020 Background As the genetic variants of trabecular bone microarchitecture are not well-understood, we performed a genome-wide association study to identify genetic determinants of bone microarchitecture analyzed by trabecular bone score (TBS).
Sung Hye Kong +8 more
doaj +1 more source
netgwas: An R Package for Network-Based Genome-Wide Association Studies
, 2019 Graphical models are powerful tools for modeling and making statistical inferences regarding complex associations among variables in multivariate data.
Arends, Danny +2 more
core +1 more source
High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping. [PDF]
, 2015 Human genome-wide association studies have identified thousands of loci associated with disease phenotypes. Genome-wide association studies also have become feasible using rodent models and these have some important advantages over human studies ...
Churchill, Gary A +6 more
core +1 more source
Statistical methods for Mendelian randomization in genome-wide association studies: A review
Computational and Structural Biotechnology Journal, 2022 Graphical ...
Frederick J. Boehm, Xiaoping Zhou
semanticscholar +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
DongâWoo Shin +2 more
wiley +1 more source
Main insights of genome wide association studies into HCV-related HCC
Egyptian Liver Journal, 2020 Background Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-mortality globally. Hepatocarcinogenesis is a complex multifactorial process.
Inas Maged Moaz +3 more
doaj +1 more source