Results 81 to 90 of about 22,469,227 (260)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Pathway analysis comparison using Crohn's disease genome wide association studies

BMC Medical Genomics, 2010
Background The use of biological annotation such as genes and pathways in the analysis of gene expression data has aided the identification of genes for follow-up studies and suggested functional information to uncharacterized genes. Several studies have
Cho Judy, Abraham Clara, Ballard David, Zhao Hongyu   +3 more
doaj   +1 more source

A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels [PDF]

, 2009
The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). We meta-analyzed 3 genome-wide association studies for circulating adiponectin levels (n =
Stewart, A.F.R., Stewart, AFR, O'Rahilly, S. (Stephen), Epstein, S.E., Pastinen, Tomi, Samani, NJ, O'Rahilly, S., Abecasis, Gonçalo R., Witteman, JC, Langenberg Claudia, Hall, A.S. (Alistair), Beate Glaser, Kijoung Song, Hengstenberg, Christian, Stephen E Epstein, Ruth J. F. Loos, Evans, D, Daniel J Rader, Witteman, J., Wichmann, H.-E., Willenborg, C., Toshiko Tanaka, Mary-Susan Burnett, Stark, K, Hingorani Aroon, König, Inke R, Langenberg, C, Samani, N., Van Duijn, C.M., Stark, K. (Klaus), Peter Vollenweider, Stark Klaus, Willenborg, C. (Christina), Robert K. Semple, Evans, D., Davey Smith George, Van Duijn, CM, Richards, J.B., Erdmann Jeanette, Loos, Ruth J F, Grassl, M., Josephine M. Egan, Davey Smith, George, Perry, John R. B., Wichmann, H.E., Frayling, Timothy M., Sladek, R. (Rob), Wichmann, H.E. (Heinz Erich), Barter Phil, Stewart Alexandre F. R., Mooser, Vincent, Waeber Gerard, John R Thompson, Vollenweider Peter, Reinhard, W, Ricketts Sally L., Waterworth, D. (Dawn), Meigs, J., Stark, Klaus, Davey Smith, G., Wichmann, H-Erich, Willenborg, Christina, Melzer, D, Pastinen, T., Reilly Muredach P., Rocha, Nuno, Hivert, MF, Thompson, J., Sattar, N, Smith, GD, Barter, P., König, I.R. (Inke), Winogradow, J, Meigs, JB, Stewart, Alexandre F.R., Reinhard, W. (Wibke), Semple, Robert K.; id_orcid, Nicholas John Timpson, Hall, AS, Ferrucci, L. (Luigi), Hivert, M., Scott Grundy, Christina Willenborg, ?, ?, Naveed Sattar, Witteman, Jaquelin C. M, Hall, A., Duijn, Cornelia, Florez, Jose, Sladek, R, Van Duijn Cornelia M., Saxena, R, Reilly, Muredach P., Soranzo, N. (Nicole), Melzer, David, Mahley Robert, Glaser, B, Prokopenko, Inga, Christian Hengstenberg, Schunkert, H, Dupuis, Josee, Loos, R.J.F. (Ruth), Wareham, N.J. (Nick), Aulchenko, Y, Koenig, Inke R., George Davey Smith, Loos, Ruth J.F., Thompson, JR, Frayling Timothy M., Barter, Phil, Deloukas Panos, Aulchenko Yurii, Sladek, Robert, Hengstenberg, C. (Christian), Wareham, N.J., Schunkert, H., Marie-France Hivert, Glaser Beate, John R B Perry, Reilly, M.P. (Muredach), Nicholas J Wareham, Claudia Langenberg, Timothy M, Rader Daniel J., Thompson, John R, McPherson, R. (Ruth), Erdmann, Jeanette, Spector, T., Vincent Mooser, Thompson, John R., O'Rahilly, Stephen, Loos, Ruth J. F., Josée Dupuis, Rader, D.J. (Daniel), Burling, K.A. (Keith), Tim D Spector, Ferrucci, L, Erdmann, J., Jose C. Florez, Konig, IR, Loos, RJF, Reilly, M., Tomi Pastinen, Dupuis, J, Luigi Ferrucci, Burnett, M., McPherson, R, Reilly, MP, Alexandre F R Stewart, H-Erich Wichmann, Brent Richards, J., Deloukas, P., Inke R. König, Egan, JM, Hivert Marie-France, Ferrucci Luigi, Mooser, V. (Vincent), Erdmann, J, Keith Burling, Grundberg, E, Burling, K, Frayling, T.M. (Timothy), Muredach P. Reilly, Grundy, S.M. (Scott), Kesaniemi, Y Antero, Burnett, MS, Waterworth, Dawn, Wareham, NJ, Consortium, GIANT, Waterworth, D, Egan, J., Frayling, TM, Waterworth, D., Perry, J.R.B. (John), Janina Winogradow, Meigs, James B., Evans, David, Martina Grassl, Waeber, Gerard, Ruth J F Loos, Semple, Robert K., Witteman Jaquelin C. M., Wareham, N., Samani, N.J. (Nilesh), Winogradow, Janina, Grundy, S, Rader, D., Cornelia M. Van Duijn, Deloukas, Panos, Rocha, N. (Nuno), Prokopenko Inga, Wareham, Nicholas J., Grundberg Elin, Van Duijn, C., Grundy, Scott, Barter, P. (Phil), Deanfield, J., Meigs, J.B., Tikka-Kleemola, P. (Päivi), Perry, J.R.B., Hengstenberg Christian, McPherson Ruth, Rader, DJ, Epstein Stephen E., Burnett, Mary-Susan, Smith, A.V. (Davey), Egan, J.M., Hivert, Marie-France, Burnett Mary-Susan, Witteman, Jaquelin C M, Willenborg, C, James B Meigs, Timpson Nicholas John, Alistair S Hall, Vollenweider, P, Stewart, Alexandre F. R., Hingorani, A, Soranzo Nicole, Dupuis, J. (Josée), Mahley, R, Spector, TD, Elin Grundberg, Semple, R.K., Grassl, M. (Martina), Tanaka, T, Aulchenko, Y.S. (Yurii), Grundberg, E. (Elin), Stewart, A.F.R. (Alexandre), GIANT Consortium, Burnett, M.-S., Panos Deloukas, Consortium, G., Dupuis Josée, Ferrucci, L., Robert Mahley, Waterworth Dawn, David Melzer, Richards, J Brent, Deanfield, John, Reinhard Wibke, Tanaka, T., Kesaniemi, YA, Deloukas, P, Winogradow, J., Florez Jose C., Reinhard, W., Devaney, J., Glaser, B., Song, K. (Kijoung), Ruth McPherson, Meigs, J.B. (James), Kesaniemi, Y., Tanaka Toshiko, Kesaniemi, Y. Antero, Reinhard, Wibke, Josephine M Egan, Hall, Alistair S., Samani, Nilesh J., Prokopenko, I. (Inga), Song, K, Langenberg, Claudia, Vollenweider, P., Winogradow, J. (Janina), Waeber, G. (Gérard), Sattar Naveed, Pastinen, T, Ferrucci, Luigi, Soranzo, N, Sladek Robert, Ricketts, S.L. (Sally), Wibke Reinhard, Sattar, Naveed, O'Rahilly Stephen, Spector, Tim D., Jeanette Erdmann, Richards, J.B. (Brent), Schunkert Heribert, Grundberg, Elin, Burnett, M.S., Rocha Nuno, Devaney Joseph, Florez, Jose C, Egan Josephine M., Hingorani, Aroon, Egan, Josephine M., Phil Barter, Hengstenberg, C, Inga Prokopenko, Stark, K., Hingorani, A., Erdmann, J. (Jeanette), Joseph Devaney, Timothy M Frayling, Frayling, T., Epstein, SE, J. Brent, Thompson, J.R., Perry, J., Samani, N.J., Rader, Daniel J., David Evans, Soranzo, N., Epstein, S., Waeber, G., Pastinen, T. (Tomi), Winogradow Janina, Glaser, Beate, Perry, JR, Wichmann, HE, Florez, J.C., Epstein, S.E. (Stephen), Wichmann, H., Semple Robert K., Sladek, R., Alistair S. Hall, Davey Smith, G, Y Antero Kesaniemi, Gerard Waeber, Thompson, J.R. (John), Perry, John R.B., Wichmann H-Erich, Egan, Josephine M, Richards, J. Brent, Semple, Robert K, Kesaniemi, Y.A. (Antero), Tanaka, T. (Toshiko), Saxena Richa, Egan, J.M. (Josephine), Saxena, Richa, Florez, J.C. (Jose), Burling Keith, Mooser Vincent, Timpson, Nicholas John, Van Duijn, Cornelia M., Timpson, NJ, Ricketts, SL, Epstein, Stephen E., Spector Tim D., Semple, R., Aulchenko, Yurii S., Nilesh J. Samani, Rocha, N, Devaney, Joseph, Prokopenko, I, Thompson John R., Florez, J., Richards J. Brent, Yurii Aulchenko, Aulchenko, Y., Saxena, R., Samani Nilesh J., Semple, RK, Mooser, V, Sattar, N. (Naveed), Ricketts, Sally L, Song, K., Grundberg, E., Langenberg, C., Ricketts, S., J. Brent Richards, Muredach P Reilly, Florez, JC, Smith, George Davey, Spector, T.D. (Timothy), Cornelia M Van Duijn, Kesaniemi, Y.A., Vollenweider, Peter, Saxena, R. (Richa), Perry, JRB, Wareham Nicholas J., John Deanfield, Prokopenko, I., Soranzo, Nicole, Burling, Keith, Witteman, JCM, Rader, D.J., Melzer David, Grassl, M, König, I.R., Perry John R. B., Stewart, A., Devaney, J. (Joseph), Song Kijoung, Sattar, N., Witteman, Jaquelin C.M., Mahley, R., Dawn Waterworth, John R. Thompson, Melzer, D. (David), Melzer, D., Evans, D.M. (David), Loos, R., Hingorani, A. (Aroon), Re F. R. Stewart, Mooser, V., Stephen E. Epstein, Pastinen Tomi, Richa Saxena, Mahley, R. (Robert), König, I., König, Inke R., Timpson, N., Nuno Rocha, Nicole Soranzo, Hengstenberg, C., Grundy Scott, Hivert, M.-F., Loos, RJ, O'Rahilly, S, Sally L Ricketts, Loos Ruth J. F., Barter, P, Stewart, AF, Wichmann, Heinz-Erich, Robert K Semple, Devaney, J, Mahley, Robert, Ricketts, Sally L., Heribert Schunkert, Klaus Stark, John R. B. Perry, Deanfield John, Schunkert, H. (Heribert), McPherson, Ruth, Tanaka, Toshiko, Dupuis, J., J Brent Richards, Aroon Hingorani, Inke R König, Daniel J. Rader, Song, Kijoung, Hivert, M.-F. (Marie-France), Jaquelin C M Witteman, Grassl, Martina, Schunkert, Heribert, Spector, T.D., Loos, R.J.F., Hall, Alistair S, Grassl Martina, Waeber, G, Semple, R.K. (Robert), Hall, A.S., Grundy, S., Florez, Jose C., Witteman, Jaquelin C. M., Perry, John R B, Frayling, T.M., Y. Antero Kesaniemi, Jose C Florez, Sally L. Ricketts, Evans David, Rocha, N., Willenborg Christina, Robert Sladek, Aulchenko, Yurii, Stephen O'Rahilly, Citation Richards, Meigs, James, Kesaniemi Y. Antero, Witteman, J.C.M. (Jacqueline), Richards, J., Timpson, N.J. (Nicholas), Deanfield, J. (John), Meigs James B., Aulchenko, Yuriy, Witteman, J.C.M., Glaser, B. (Beate), Richards, JB, König Inke R., Vollenweider, P. (Peter), Burling, K., Deanfield, J, McPherson, R., Deloukas, P. (Panagiotis), Nilesh J Samani, Timpson, N.J., Langenberg, C. (Claudia), Hall Alistair S., Reilly, M.P., Jaquelin C. M. Witteman, Ricketts, S.L., Smit George, Davey, Kesaniemi Y. Antero,, Van Duijn Cornelia, M, Richards J. Brent,, Ricketts Sally, L, Thompson John, R, Stewart Alexandre F. R,, Samani Nilesh, J., Epstein Stephen, E, Reilly Muredach, P, Koenig Inke, R, Hall Alistair, S, Rader Daniel, J, Meigs James, B., Timpson Nicholas, John, Wareham Nicholas, J., Spector Tim, D., Frayling Timothy, M., Semple Robert, K, Egan Josephine, M., Witteman Jaquelin, C. M., Grundberg, Elin, Perry John R. B,, Loos Ruth J. F,, Florez Jose, C.   +505 more
core   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Genome-Wide Association Studies of Multiple Keratinocyte Cancers.

PLoS ONE, 2017
There is strong evidence for a role of environmental risk factors involved in susceptibility to develop multiple keratinocyte cancers (mKCs), but whether genes are also involved in mKCs susceptibility has not been thoroughly investigated. We investigated
Luba M Pardo, Wen-Qing Li, Shih-Jen Hwang, Joris A C Verkouteren, Albert Hofman, André G Uitterlinden, Peter Kraft, Constance Turman, Jiali Han, Eunyoung Cho, Joanne M Murabito, Daniel Levy, Abrar A Qureshi, Tamar Nijsten   +13 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

A genome-wide association study identifies protein quantitative trait loci (pQTLs) [PDF]

, 2008
There is considerable evidence that human genetic variation influences gene expression. Genome-wide studies have revealed that mRNA levels are associated with genetic variation in or close to the gene coding for those mRNA transcripts - cis effects, and ...
Marjo-Riitta Jarvelin, Simon-Sanchez, J, Hana Lango, Henley W, Greg Tranah, HURST A., Singleton, A, Murray, A, WEEDON M., McCarthy, Mark I, Rafferty I, Lango H, David Melzer, Rafferty, Ian, Singleton A, Bandinelli, S, Bennett, A, BRITTON A., Hurst, A, Newman, Anne B, van de Leemput J, Colin Dayan, GIBBS J., Paolisso, G, Lango, H, Dayan, Colin; id_orcid, Hurst A, Anne B Newman, Murray, Anna, FRAYLING T., Tranah, G, Panicker, V, Perry, John R. B., SHOLZ S., Frayling, Timothy M., Ferrucci, Luigi, Scholz, Sonja, Corsi AM, RICE N., Simon-Sanchez J, J Raphael Gibbs, Tranah G, Harris, Tamara, Jarvelin, Marjo-Riitta, Ruokonen A, Jarvelin, Marjo Riitta, Melzer, D, Paolisso G, Javier Simon-Sanchez, AREPALLI S., Amanda Bennett, Timothy M Frayling, Murray A, Scholz, S, Henley, William E., Hernandez D, Fulvio Lauretani, Hurst, Alison, Singleton, Andrew, RAFIQ S., Jarvelin MR, Rafiq S, McCarthy, MI, Perry, JR, Rafiq, S, Arepalli, S, van de Leemput, Joyce, PANICKER V., TRANAH G., Guralnik, J, Stevens K, Dayan, Colin M., Melzer, David, Rongling Li, Giuseppe Paolisso, Gibbs, J. Raphael, STEVENS K., Sajjad Rafiq, Corsi, Anna Maria, Perry JRB, Bennett A, Harris, T, Perry, John R.B., Bandinelli, Stefania, Nicole Washecka, Lauretani, Fulvio, Lango, Hana, Dena Hernandez, Harris T, Scholz S, McCarthy, Mark I., Frayling, Timothy M, William Henley, HARRIS T., Guralnik J, Stevens, K, Panicker, Vijay, Jack Guralnik, Li, R, DAYAN C., McCarthy MI, Rice N, Weedon, Michael N., Sampath Arepalli, Dayan C, Guralnik, Jack, Lauretani, F, John R B Perry, Melzer D, Dayan, C, Newman, Anne B., Lauretani F, RAFFERTY I., Britton A, Newman AB, Sonja Scholz, Angela Britton, HERNANDEZ D., Frayling TM, Corsi, Anna-Maria, Britton, A, Washecka, Nicole, Andrew Singleton, Ferrucci, L, Tamara Harris, LANGO H., Gibbs, JR, BENNET A., Perry, JRB, Dayan, Colin Mark, Michael N Weedon, Weedon, Michael N, Luigi Ferrucci, Bennett, Amanda, Neil Rice, Rice, N, Anna-Maria Corsi, BANDINELLI S., Washecka, N, Henley, William, Ruokonen, Aimo, Henley, W, Gibbs JR, SIMON SANCHEZ J., Kara Stevens, Arepalli, Sampath, Stevens, Kara, Joyce van de Leemput, MELZER D., Weedon MN, Frayling, TM, Panicker V, SINGLETON A., Weedon, MN, Dayan, Colin, Jarvelin, MR, Anna Murray, Arepalli S, Ferrucci L, FERRUCCI L., Rice, Neil, Li, Rongling, Tranah, Greg, Washecka N, HENLEY W., MCCARTHY M., Perry, John RB, Ruokonen, A, JARVELIN M., Li RL, VAN DE LEEMPUT J., Rafiq, Sajjad, PERRY J., Hernandez, Dena, WASHECKA N., Mark I McCarthy, Vijay Panicker, Ian Rafferty, MURRAY A., LI R., Newman, AB, Bandinelli S, NEWMAN A., Gibbs, J Raphael, Paolisso, Giuseppe, GURALNIK J., Hernandez, D, CORSI A., Van De Leemput, J, Simon-Sanchez, Javier, Stefania Bandinelli, Alison Hurst, RUOKONEN A., Corsi, AM, Britton, Angela, Rafferty, I, Aimo Ruokonen, et al,   +197 more
core   +1 more source

I-GWAS: Privacy-Preserving Interdependent Genome-Wide Association Studies

, 2022
Genome-wide Association Studies (GWASes) identify genomic variations that are statistically associated with a trait, such as a disease, in a group of individuals.
Decouchant, Jérémie (author), Pascoal, Túlio (author), Boutet, Antoine (author), Völp, Marcus (author)   +3 more
core   +1 more source