Results 91 to 100 of about 1,107,991 (320)

Voxelwise genome-wide association study (vGWAS) [PDF]

NeuroImage, 2010
The structure of the human brain is highly heritable, and is thought to be influenced by many common genetic variants, many of which are currently unknown. Recent advances in neuroimaging and genetics have allowed collection of both highly detailed structural brain scans and genome-wide genotype information.
Jason L, Stein, Xue, Hua, Suh, Lee, April J, Ho, Alex D, Leow, Arthur W, Toga, Andrew J, Saykin, Li, Shen, Tatiana, Foroud, Nathan, Pankratz, Matthew J, Huentelman, David W, Craig, Jill D, Gerber, April N, Allen, Jason J, Corneveaux, Bryan M, Dechairo, Steven G, Potkin, Michael W, Weiner, Paul, Thompson   +18 more
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Robust Reference Powered Association Test of Genome-Wide Association Studies

Frontiers in Genetics, 2019
Genome-wide association studies (GWASs) have identified abundant genetic susceptibility loci, GWAS of small sample size are far less from meeting the previous expectations due to low statistical power and false positive results.
Yi Wang, Yi Wang, Yi Li, Yi Li, Yi Li, Meng Hao, Meng Hao, Xiaoyu Liu, Xiaoyu Liu, Menghan Zhang, Jiucun Wang, Jiucun Wang, Momiao Xiong, Yin Yao Shugart, Yin Yao Shugart, Li Jin, Li Jin   +16 more
doaj   +1 more source

Genome-wide association studies of inflammatory bowel disease in German shepherd dogs [PDF]

, 2018
Canine Inflammatory Bowel Disease (IBD) is considered a multifactorial disease caused by complex interactions between the intestinal immune system, intestinal microbiota and environmental factors in genetically susceptible individuals.
Allenspach, Karin, Bertolini, Francesca, Jergens, Albert, Peiravan, Atiyeh, Rothschild, Max, Rothschild, Max, Simpson, Kenneth, Werling, Dirk   +7 more
core   +6 more sources

FINEMAP: efficient variable selection using summary data from genome-wide association studies

bioRxiv, 2015
Motivation The goal of fine-mapping in genomic regions associated with complex diseases and traits is to identify causal variants that point to molecular mechanisms behind the associations.
C. Benner, C. Spencer, A. Havulinna, V. Salomaa, S. Ripatti, M. Pirinen   +5 more
semanticscholar   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Novel candidate plasma proteins for the pathogenesis and treatment of atopic dermatitis revealed by proteome-wide association study

Scientific Reports
Atopic dermatitis (AD) is an immune-related skin disease with a genetic background. Numerous loci have been identified associated with AD to better comprehend its complicated genetic mechanisms by genome‑wide association studies (GWASs). However, current
Chen Luo, YaJing Zhang, QiFan Feng, KaiXin Yao, LeiLei Zheng, Ye Yang, WenXin Zheng, Feng Li, YongQiang Lv, Yue Cai   +9 more
doaj   +1 more source

Genome-Wide Association Studies of Multiple Keratinocyte Cancers.

PLoS ONE, 2017
There is strong evidence for a role of environmental risk factors involved in susceptibility to develop multiple keratinocyte cancers (mKCs), but whether genes are also involved in mKCs susceptibility has not been thoroughly investigated. We investigated
Luba M Pardo, Wen-Qing Li, Shih-Jen Hwang, Joris A C Verkouteren, Albert Hofman, André G Uitterlinden, Peter Kraft, Constance Turman, Jiali Han, Eunyoung Cho, Joanne M Murabito, Daniel Levy, Abrar A Qureshi, Tamar Nijsten   +13 more
doaj   +1 more source

Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations.

Cell, 2019
Genome-wide association studies (GWASs) have focused primarily on populations of European descent, but it is essential that diverse populations become better represented.
Roseann E. Peterson, K. Kuchenbaecker, R. Walters, Chia-Yen Chen, A. Popejoy, S. Periyasamy, Max W. Y. Lam, C. Iyegbe, R. Strawbridge, L. Brick, C. Carey, Alicia R. Martin, J. Meyers, J. Su, Junfang Chen, Alexis C. Edwards, Allan Kalungi, Nastassja Koen, L. Majara, E. Schwarz, J. Smoller, E. Stahl, P. Sullivan, E. Vassos, B. Mowry, M. Prieto, A. Cuellar-Barboza, T. Bigdeli, H. Edenberg, Hailiang Huang, L. Duncan   +30 more
semanticscholar   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source