Results 101 to 110 of about 22,469,227 (260)
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...Jack P. K. Bravowiley +1 more sourceAn integrative analysis of genome-wide association study and regulatory SNP annotation datasets identified candidate genes for bipolar disorder
International Journal of Bipolar Disorders, 2020 Background Bipolar disorder (BD) is a complex mood disorder. The genetic mechanism of BD remains largely unknown. Methods We conducted an integrative analysis of genome-wide association study (GWAS) and regulatory SNP (rSNP) annotation datasets ...Xin Qi, Yan Wen, Ping Li, Chujun Liang, Bolun Cheng, Mei Ma, Shiqiang Cheng, Lu Zhang, Li Liu, Om Prakash Kafle, Feng Zhang +10 moredoaj +1 more sourceGenome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke [PDF]
, 2012 Genetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of ...Furie, K., Seedorf, Udo, Cathie L M Sudlow, Spencer, C.C.A., Woo, D., Müller-Myhsok, B., Jackson, C. A., Sawcer, SJ, Markus, Hugh S, Lindgren, Arne,, Segal, H, Viswanathan, Ananth C., Syme, P. D., Valerie Valant, Rautanen, A, Matthew Traylor, Gray, E, Sarah Edkins, Attia, J., Palmer, C., Rothwell, Peter M., Juan P Casas, Levi, Chris, Worrall, Bradford B, Levi, C., Jankowski, J., Peltonen, L, Palmer, Colin N. A., Sawcer, S., Edkins, Sarah, Delavaran, Hossein,, Kissela, Brett, Pankaj Sharma, WTCCC2, Sharma, P, Goel, A, Gray, E., Joanna Pera, Palmer, CN, Boonen, S., Worrall, BB, Dorota Wloch-Kopec, Cordelia Langford, Helgadottir, A, Steve Bevan, Su, Zhan, Rothwell, Peter M, Sudlow, Cathie LM, Wellcome Trust Case Control Consortium 2 (WTCCC2) (), Bradford B Worrall, Viswanathan, A.C., Hossein Delavaran, Valant, V., Nalls, Michael A., Stefansson, K, Donnelly, P, Palmer, Colin NA, Worrall, B., Wloch-Kopec, D., Martin Farrall, Elvira Bramon, Lindgren, Arne, Valant, V, Kittner, Steven J., Corvin, A., Syme, PD, Meisinger, Christa, Schanz, R., Delavaran, H, Goel, Anuj, Audrey Duncanson, Unnur Thorsteinsdottir, Syme, P.D., Bramon, E, Stephen J Sawcer, Pirinen, Matti, Burgess, A., Kissela, B., Cheng, Y., Helen Segal, Cheng, YC, Meschia, JF, Edkins, S., Levi, C, Parati, E. A., Rainer Malik, Meschia, J., Trembath, R., Cortellini, L., Burgess, AI, Trembath, RC, ?, ?, Langford, C, Boncoraglio, G. B., Bevan, S, Poole, D, International Store Genetics Consortium, Burgess, A.I., Spencer, Chris CA, Spencer, Chris, Nalls, M.A., Bellenguez, C., Matthew Walters, Traylor, M, Boncoraglio, G.B., Attia, John, Freeman, Colin, Jackson, Caroline; id_orcid, Lemmens, Robin, Spencer, Chris C. A., Sudlow, Cathie L M, Ross-Adams, H., Thijs, V, Gray, Emma, Hugh S Markus, Dichgans, M, Nicholas W Wood, Wellcome Trust Case Control Consortium 2 (WTCCC2), Brown, MA, Norrving, Bo,, Wood, N.W., Brown, M., Burgess, Annette I, International Stroke Genetics Consortium (Meisinger, C.), Emma Gray, Mitchell, BD, Colin Freeman, Giorgio B Boncoraglio, Norrving, B., Franzosi, MG, James, T., Slark, Julia, Mitchell, B., Murphy, Lee, Wood, N. W., Goel, A., Julia Slark, Seedorf, U, Boonen, S, Udo Seedorf, Boonen, Steven, Sharma, Pankaj, Deborah Poole, Rothwell, PM, Casas, J., Su, Z., Edkins, S, Cheng, Yu-Ching, Colin N A Palmer, Franzosi, M., Lund University., Lee Murphy, Elizabeth Holliday, Wood, Nicholas W, Rothwell, P., Viswanathan, Ananth C, Norrving, Bo, Anuj Goel, Tom James, Casas, J. P., Gretarsdottir, S., Sarah Hunt, Sudlow, C.L.M., Gschwendtner, A., Bevan, Steve, Deloukas, P., Müller-Myhsok, Bertram, Janusz Jankowski, Yu-Ching Cheng, Macleod, M.J., Dronov, S, Slowik, A, Walters, Matthew, Meschia, James F, Pera, J, Plomin, R, Spencer, CCA, Casas, JP, Brown, Matthew A, Mathew, Christopher G., Peltonen L, Holliday, E., Slowik, A., Bramon, Elvira, Plomin, Robert, Cheng, Y. C., Band, G., Thorsteinsdottir, U, Helen Ross-Adams, Sudlow, C., Strange, A, Band, Gavin, Markus, H.S., Wellcome Trust Control Consortium, Rautanen, A., Nalls, Michael A, Worrall, B. B., Blackwell, J. M., Casas, Juan P., Deloukas, Panos, Macleod, MJ, Thijs, Vincent, Spencer, C., Ananth C Viswanathan, Traylor, M., Duncanson, A., Poole, Deborah, Bramon, E., Wloch-Kopec, D, Spencer, CC, Holliday, E, Macleod, Mary Joan, Band, G, Palmer, CNA, Bevan, S., Viswanathan, AC, Poole, D., Schanz, R, Macleod, M., Palmer, C. N. A., Meisinger, C., Furie, Karen, Viswanathan, A., Woo, Daniel, Delavaran, H., Dronov, S., International Stroke Genetics Consortium (ISGC), Anna Helgadottir, Kissela, B, Corvin, Aiden, Sudlow, CL, Casas, J.P., Annette I Burgess, Markus, H. S., Helgadottir, Anna, Panos Deloukas, Jackson, C., Jackson, Caroline A., Mitchell, Braxton D., Walters, M., Bertram Müller-Myhsok, Franzosi, M-G, Bo, N, Donnelly, P., Burgess, A. I., Andreas Gschwendtner, Deloukas, P, Rosand, Jonathan, Gavin Band, Langford, C., Vincent Thijs, Sawcer, Stephen J, Cortellini, L, Delavaran, Hossein, Solveig Gretarsdottir, Peltonen, L., Burgess, Annette I., Wood, N., Lemmens, R, Mueller-Myhsok, Bertram, Parati, E.A., Franzosi, M. G., Farrall, M, Segal, H., Corvin, A, Kittner, Steven J, Mathew, Christopher G.; id_orcid, Sudlow, Catherine; id_orcid, Valant, Valerie, Hunt, S., Leena Peltonen, Palmer, C.N.A., Franzosi, Maria-Grazia, Mary Joan Macleod, Segal, Helen, Wood, Nicholas W., Arne Lindgren, Hunt, S, Bellenguez, Céline, Daniel Woo, Kari Stefansson, Rothwell, P.M., Furie, K, Matti Pirinen, Murphy, L, Céline Bellenguez, Dichgans, M., Boncoraglio, Giorgio B, Peter M Rothwell, Blackwell, Jenefer M., Christopher G Mathew, Duncanson, A, Jonathan Rosand, Trembath, Richard C, Sudlow, CLM, Chris C A Spencer, Pera, Joanna, Nalls, M. A., Meisinger, C, Rosand, J., James F Meschia, Palmer, Colin N A, Gudmar Thorleifsson, Wloch-Kopec, Dorota, Robin Lemmens, Agnieszka Slowik, Markus, H., Lemmens, R., Slark, J., Kittner, S. J., Boncoraglio, Giorgio B., Viswanathan, A. C., Cortellini, Lynelle, Peltonen, Leena, Sawcer, Stephen J., Seedorf, U., Parati, E., Peter Donnelly, Serge Dronov, Worrall, Bradford B., Mitchell, Braxton D, Malik, R., Boncoraglio, GB, Strange, Amy, Lindgren, A, Caroline A Jackson, Freeman, C., Thorsteinsdottir, Unnur, Brown, M. A., Jenefer M Blackwell, Bo, N., Wood, NW, Langford, Cordelia, Ross-Adams, Helen, Parati, Eugenio A, Hunt, Sarah, Stefansson, K., Blackwell, Jenefer M, Boncoraglio, G., Markus, HS, Rosand, J, Jackson, Caroline A, Norrving, B, Dronov, Serge, Anna Rautanen, Farrall, M., Jackson, CA, Sudlow, C. L. M., Thorleifsson, G, Malik, R, Slowik, Agnieszka, Lindgren, A., Amy Strange, Mathew, C., Renata Schanz, James, Tom, Ross-Adams, H, Matthew A Brown, Farrall, Martin, Syme, Paul D, Schanz, Renata, Mathew, CG, Helgadottir, A., Donnelly, Peter, Brett Kissela, Stefansson, Kari, Pirinen, M., Sharma, P., Mathew, Christopher G, Martin Dichgans, Nalls, M., Zhan Su, Parati, EA, Attia, J, Gretarsdottir, Solveig, Trembath, Richard C., Kittner, S., Pirinen, M, Nalls, MA, Cheng, Y-C, Müller-Myhsok, B, Strange, A., Blackwell, JM, Slark, J, Sudlow, Cathie L. M., Thorsteinsdottir, U., Kittner, S.J., Mathew, C. G., Su, Z, Plomin, R., Kittner, SJ, Spencer, Chris C A, Jackson, C.A., Worrall, B.B., Casas, Juan P, Gschwendtner, Andreas, Dichgans, Martin, Blackwell, J., Thorleifsson, G., Michael A Nalls, Gschwendtner, A, Macleod, M. J., Aiden Corvin, Eugenio A Parati, Murphy, L., Rautanen, Anna, Thorleifsson, Gudmar, Jankowski, Janusz, Freeman, C, Syme, P., Sawcer, S.J., Meschia, J. F., Steven J Kittner, John Attia, Brown, Matthew A., Rothwell, P. M., Syme, Paul D., ISGC, Parati, Eugenio A., Markus HS, Robert Plomin, James, T, Walters, M, Mitchell, B. D., Bo Norrving, Trembath, R. C., Meschia, J.F., Pera, J., Duncanson, Audrey, Mitchell, B.D., Woo, D, Spencer, C. C. A., Markus, Hugh S., Jankowski, J, Blackwell, J.M., Chris Levi, Thijs, V., Gretarsdottir, S, Christa Meisinger, Richard C Trembath, Holliday, Elizabeth, Steven Boonen, Mathew, C.G., Murphy, Lee; id_orcid, Bellenguez, C, Meschia, James F., Malik, Rainer, Braxton D Mitchell, Sawcer, S. J., Traylor, Matthew, Karen Furie, Trembath, R.C., Lynelle Cortellini, Maria-Grazia Franzosi, Paul D Syme, Palmer, Colin N. A.; id_orcid +455 morecore +2 more sourcesThe Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen +6 morewiley +1 more sourceMeta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque [PDF]
, 2011 Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events.Taylor, K, Rice, K. (Kenneth), Petrovic, K. (Katja), Orru, M, Meisinger, C. (Christa), Fox, Caroline S., Ralph B D'Agostino, Ballantyne, C. (Christie), Rivadeneira Ramirez, F. (Fernando), Demissie, S, Sanna, Serena, Harris, Tamara B, Markus, Hugh S, Petrovic, KE, Huffman, J.E. (Jennifer), White, C.C. (Charles), Heiss, G. (Gerardo), Sanna, S, Eiriksdottir, Gudny, Newman, Anne B, Peltonen, L, Smith, AV, Huffman, JE, Couper, DJ, Huffman, Jennifer E., Blankenberg, Stefan, Baumert, J. (Jens), Lüdemann, Jan, Reinhold Schmidt, Arne Schillert, Sitzer, M, Dörr, M. (Marcus), Manuela Uda, Steve Bevan, Serkalem Demissie, Boerwinkle, Eric, Xia Li, O'Leary, Daniel H, Eiriksdottir, G, Ulf Schminke, O'Donnell, CJ, Wichmann, H.E. (Heinz Erich), Kavousi, M, Halperin, E, Boerwinkle, E, Illig, T. (Thomas), Heiss, G, Heckbert, Susan R, Bis, JC, Tamara B Harris, Harris, T.B. (Tamara), Smith, Albert V, Launer, Lenore J, Ziegler, A, Schmidt, Reinhold, Heckbert, Susan R., Meisinger, Christa, Wild, P.S. (Philipp), Polak, Joseph F., Klopp, Norman, Cupples, L.A. (Adrienne), Joseph F Polak, Aspelund, T. (Thor), Wolf, PA, Couper, David J., Alan R Shuldiner, White, Charles C, Rivadeneira, F, Homuth, G, Gonçalo R Abecasis, Cheng, YC, Maryam Kavousi, Taylor, Kent, White, CC, Li, X. (Xia), ?, ?, Orru, Marco, Wild, PS, Bevan, S, Duijn, Cornelia, Wendy S Post, Abbas Dehghan, Halperin, E. (Eran), Luedemann, Jan, Smith, A.V. (Albert Vernon), Münzel, T, Franceschini, N. (Nora), Kähönen, M, Stoegerer, EM, Baumert, Jens, Reilly, Muredach P., Thomas Illig, Völzke, H. (Henry), Homuth, G. (Georg), D'Agostino, RB, Lenore J Launer, Schminke, Ulf, Christie Ballantyne, Franceschini, N, Uda, Manuela, Wild, Philipp S, Scuteri, Angelo, Huffman, Jennifer E, Rice, Kenneth, Hugh S Markus, Christopher J O'Donnell, Launer, Lenore J., Usala, G, Fernando Rivadeneira, Jacqueline Witteman, Post, WS, Norman Klopp, Gudnason, V. (Vilmundur), Petrovic, Katja E., Mitchell, BD, Uitterlinden, Andre, Post, W.S. (Wendy S.), Wolf, Philip A, Reilly, M.P. (Muredach), Rotter, Jerome I, Franceschini, Nora, Newman, Anne B., Andreas Ziegler, Marco Orru, Uitterlinden, A, Fox, CS, Dörr, Marcus, Schnabel, R.B. (Renate), Edward G Lakatta, Nambi, Vijay, Isaacs, Aaron; id_orcid, Cheng, Yu-Ching, Uitterlinden, A.G. (André), Ben Oostra, Wilson, James F, Stefan Blankenberg, Schmidt, Helena, O'Donnell, C.J. (Christopher), Koenig, W, Völzke, H, Reilly, MP, Thomas Münzel, Mika Kähönen, Dehghan, Abbas, Gudnason, V, Bevan, Steve, Raitakari, O, Thorsson, Bolli, Yu-Ching Cheng, Isaacs, A.J. (Aaron), Caroline S Fox, Koenig, Wolfgang, Albert V Smith, Cupples, LA, Rathmann, W, Bruce M Psaty, Andre Uitterlinden, Zeller, T, Smith, Albert V., Shuldiner, Alan R, Florian Ernst, Ballantyne, C, Kavousi, M. (Maryam), Chilukoti, R.K. (Ravi Kumar), Ziegler, Andreas, Duijn, CV, Schillert, A, Lakatta, Edward G., Psaty, B.M. (Bruce), Homuth, Georg, Harris, TB, O'Leary, D.H. (Daniel H.), Ernst, Florian, Raitakari, Olli, Post, Wendy S, Shuldiner, AR, Demissie, S. (Serkalem), Abecasis, GR, Oostra, B.A. (Ben), Schnabel, RB, Joshua C Bis, Wilson, James F., Kathiresan, S. (Sekar), Gerardo Heiss, Thor Aspelund, Hofman, Albert, Eric Boerwinkle, Illig, Thomas, Mitchell, B.D. (Braxton), Schillert, Arne, Hayward, C, Voelzke, Henry, North, K, Polak, Joseph F, Polak, JF, Halperin, Eran, Lehtimäki, T. (Terho), Tanja Zeller, Lakatta, E. (Edward), Joachim Thiery, Helena Schmidt, David J Couper, Aaron Isaacs, Demissie, Serkalem, Rotter, JI, Seissler, J. (Jochen), Petrovic, Katja E, Chilukoti, Ravi Kumar, Duijn, C.M. (Cornelia) van, Thiery, Joachim, Thorsson, B. (Bolli), Schillert, A. (Arne), Psaty, Bruce M., Mitchell, Braxton D., Henry Völzke, Kenneth Rice, Lüdemann, J, Lehtimaki, Terho, Isaacs, A, Marcus Dörr, Matthias Sitzer, Witteman, Jacqueline, Uda, M. (Manuela), Bis, Joshua C, Lehtimäki, T, Shuldiner, A.R. (Alan), Bevan, S. (Steve), null null, Serena Sanna, H Erich Wichmann, Lakatta, EG, Abecasis, G.R. (Gonçalo), Parsa, Afshin, Bis, J.C. (Joshua), Uda, M, Wichmann, H Erich, Blankenberg, S. (Stefan), Shuldiner, Alan R., Anne B Newman, Hofman, Bert, North, Kari, Thiery, J.P. (Joachim), Dörr, M, Afshin Parsa, Vijay Nambi, Zeller, Tanja, Schminke, U. (Ulf), Chilukoti, RK, Leena Peltonen, Rotter, J.I. (Jerome), Psaty, Bruce M, Heckbert, SR, Dehghan, A, Nambi, V, Witteman, J, Polak, J.F. (Joseph F.), Jorma Viikari, Kari North, Eran Halperin, Daniel H O'Leary, Wolf, Philip A., Seissler, Jochen, Usala, G., O'Leary, DH, Heckbert, S.R. (Susan), Ballantyne, Christie, Nora Franceschini, North, K.E. (Kari), Jennifer E Huffman, Jan Lüdemann, Vilmundur Gudnason, Meisinger, C, Jens Baumert, Rivadeneira, Fernando, Ziegler, A. (Andreas), O'Donnell, Christopher J., Eiriksdottir, G. (Gudny), Kathiresan, S, Wolf, P.A. (Philip), Cheng, Y.C. (Yu Ching), van Duijn, Cornelia, Rathmann, Wolfgang, Wolfgang Koenig, Zeller, T. (Tanja), Peltonen, Leena, Kent Taylor, Kähönen, M. (Mika), D'Agostino, Ralph B, Olli Raitakari, Völzke, Henry, Ernst, F, Mitchell, Braxton D, Wichmann, HE, Heiss, Gerardo, Muenzel, Thomas, Abecasis, Goncalo R., Koenig, W. (Wolfgang), James F Wilson, Viikari, J. (Jorma), Wilson, James F; id_orcid, Boerwinkle, E.A. (Eric), Susan R Heckbert, Markus, HS, Seissler, J, Bis, Joshua C., O'Leary, Daniel H., Klopp, N, Ravi Kumar Chilukoti, Stoegerer, E.M. (Eva Maria), Usala, Gianluca, Fox, C.S. (Caroline), Caroline Hayward, Harris, Tamara B., Li, X, Parsa, A, Jochen Seissler, Abecasis, Gonçalo R, Illig, T, Jerome I Rotter, Cupples, L Adrienne, Cupples, L. Adrienne, Launer, LJ (Lenore), Gudnason, Vilmundur, Lakatta, Edward G, Schmidt, R, Scuteri, A, Bolli Thorsson, Stoegerer, Eva-Maria, Uitterlinden, André; id_orcid, Post, Wendy S., Schmidt, R. (Reinhold), Schmidt, H, Kahonen, Mika, Cornelia van Duijn, Angelo Scuteri, Philipp S Wild, Viikari, J, Schnabel, Renate B, Baumert, J, Peltonen, L. (Leena Johanna), Renate B Schnabel, Sekar Kathiresan, Muredach P Reilly, D'Agostino, Ralph Sr., Rice, K, Philip A Wolf, Parsa, A. (Afshin), Doerr, Marcus, Orrù, M. (Marco), White, Charles C., Dehghan, A. (Abbas), Hayward, Caroline, Hofman, A. (Albert), Münzel, Thomas, Witteman, JCM, Blankenberg, S, Albert Hofman, Schnabel, Renate B., O'Donnell, Christopher J, D'Agostino, Ralph B., Sr., Sitzer, Matthias, CARDIoGRAM Consortium, Katja E Petrovic, Viikari, Jorma, Oostra, B, Ernst, F.D.J. (Florian), Aspelund, T, Rathmann, W. (Wolfgang), D'Agostino, R.B. (Ralph), Couper, D.J. (David), Couper, David J, Thorsson, B, Psaty, BM, Wolfgang Rathmann, Hayward, C. (Caroline), Oostra, Ben, Aspelund, Thor, Reilly, Muredach P, Georg Homuth, Markus, H.S. (Hugh S.), Lüdemann, J. (Jan), Gianluca Usala, Taylor, K.D. (Kent), Isaacs, Aaron, Wichmann, H. Erich, Raitakari, O. (Olli), Hofman, A, Kathiresan, Sekar, Wilson, JF, Launer, L.J. (Lenore), Markus, Hugh S., Schminke, U, Charles C White, Launer, LJ, Thiery, J, Sanna, S. (Serena), Duijn, Cornelia van, Newman, AB, Newman, A.B. (Anne), Christa Meisinger, Witteman, J.C.M. (Jacqueline), Klopp, N. (Norman), Wild, Philipp S., Wilson, J.F. (James), Eva-Maria Stoegerer, Hayward, Caroline; id_orcid, Kavousi, Maryam, Nambi, V. (Vijay), Sitzer, M. (Matthias), Rotter, Jerome I., Münzel, T. (Thomas), Gudny Eiriksdottir, Braxton D Mitchell, L Adrienne Cupples, Terho Lehtimäki, Li, Xia, Scuteri, A. (Angelo), Fox, Caroline S +417 morecore +1 more sourceA context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos +9 morewiley +1 more source
