Results 111 to 120 of about 22,469,227 (260)
A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis [PDF]
, 2009 The cause of sporadic amyotrophic lateral sclerosis (ALS) is largely unknown, but genetic factors are thought to play a significant role in determining susceptibility to motor neuron degeneration.
Sendtner, M., Ding, J., Guralnik, J., Sabatelli, M., Dunkley, T., Marinou, K., F. Valentino, Singleton, A, LA BELLA V, Shiao-Lin Lai, Zachary Simmons, D. J. Hunter, LA BELLA, Vincenzo, MANCARDI GL, Hardy, J., Bandinelli, S, Fisher, E.M., Wichmann, H.-E., Beck, M, SCHMIDT S, Carlesi, C, ORRELL RW, Lupoli ,S, CAPONNETTO C, Federica Lombardo, Kwee, L. C., SICILIANO, GABRIELE, Bandinelli ,S, Mancardi, GL, D. Hernandez, Arepalli ,S, Connor ,J, I. Rafferty, Kwee ,LC, Schymick, JC, Chanock ,SJ, Siciliano, G., Conte, Amelia, Bandinelli, S., F. Torri, Gieger, C, MANCARDI, GIOVANNI LUIGI, SCHYMICK J, J. Ding, Singleton ,A, Sabatelli ,M, Dunkley ,T, KASPERAVICIUTE D, Hunter ,DJ, Simmons ,Z, Lupoli, S., Schmidt ,S, Beck ,M, Giannini, F., Rothstein ,J, Carlesi, C., Pioro, EP, CHANOCK SJ, PIORO E, Oddone, E.Z., Macciardi, F., S. Arepalli, VALENTINO F, Lai, S.-L., B. J. Traynor, Sara Lupoli, Mandrioli, J, Stefania Battistini, Schymick, J. C., STEPHAN D, FUNG H, Kasperaviciute, D., Gibbs, J.R., Mancardi ,GL, CARLESI, CECILIA, M. Sendtner, H. Fung, Arepalli, S, Guralnik, J, Mandrioli ,J, Battistini ,S, Lupoli, S, MORA G, KWEE L, Mario Sabatelli, KWEE LC, Ilaria Bartolomei, Schymick,JC, Hardy ,J, Sendtner, M, Adriano Chiò, Sola, P, Dena Hernandez, LAI S, Kwee, LC, Ding, J.H., Battistini, S., Wichmann, H. E., Crews ,C, MUTANI R, Salvi, F, Simmons, Z, J. Mandrioli, Carlesi ,C, Calvo, A., SABATELLI M, Sampath Arepalli, BATTISTINI S, Rothstein, J, NALLS M, A. Calvo, Salvi ,F, Scholz, S. W., Jabonka ,S, ODDONE E, FISHER E, TRAYNOR BJ, CHIO' A, Sola ,P, Chanock, S.J., K. Marinou, Valentino, F, Britton, A, Travis Dunkley, Andrew Singleton, Fisher, E. M., Ferrucci, L, Hunter, DJ, C. Crews, Gibbs, JR, F. Salvi, CONTE A, HARDY J, Mancardi, G.L., Dunkley, T, FUNG HC, L. Ferrucci, Dalia Kasperaviciute, Luigi Ferrucci, Lucie Bruijn, BERGER S, Beck, M., Scholz,SW, Fisher, EM, Sola, P., TORRI F, Lombardo, F, BARTOLOMEI I, Nalls, M, Restagno,G, Sonja W. Scholz, Amelia Conte, S. Bandinelli, Salvi, F., Restagno, G, Thomas ,G, Conte, A., Sendtner ,M, Z. Simmons, SENDTNER M, Mora, G, Macciardi, F, C. Caponnetto, Michael Nalls, Tedeschi ,G, G. Restagno, TRAYNOR B., LOMBARDO F, Scholz, S.W., Crews, C, L. Bruijn, Lai ,SL, Ding ,J, James Connor, Mutani, R., Caponnetto, C., Wichmann ,HE, E. P. Pioro, Hernandez ,D, H. E. Wichmann, Ferrucci ,L, Monsurro, M.R., Britton ,A, SICILIANO G, A. Conte, Jabonka, S, Tedeschi, G, Stephan, D.A., John Hardy, Rafferty, I., DING J, Gabriele Mora, CHIÒ A, P. Sola, Erik P. Pioro, Chanock, SJ, Kalliopi Marinou, Stephen J. Chanock, Mora ,G, Stephan, D. A., TEDESCHI G, Chio, A., Connor, J, Sibylle Jabonka, Traynor, B.J., Nalls ,M, David J. Hunter, Gibbs ,JR, BECK M, MONSURRO', Maria Rosaria, Bruijn, L., S. Berger, Pioro, E.P., H. C. Fung, FERRUCCI L, RESTAGNO G, LAI SL, Hernandez, D, F. Lombardo, J. Hardy, Jeffrey Rothstein, Ding, J, J. C. Schymick, Restagno, G., Valentino, F., Stefania Bandinelli, Gieger ,C, Lai, SL, Giovanni Luigi Mancardi, Rafferty, I, R. Mutani, C. Gieger, HUNTER D, Eugene Z. Oddone, Oddone, E. Z., Maria Rosaria Monsurrò, Ferrucci, L., D. Kasperaviciute, Vincenzo La Bella, ORRELL R, S. Battistini, G. Tedeschi, Fung, HC, Pioro, E. P., ROTHSTEIN J, CHANOCK S, Connor, J., Thomas, G., Arepalli, S., A. Chiò, Oddone, EZ, TEDESCHI, Gioacchino, Bryan J. Traynor, S. Lai, Kwee, L.C., Mutani, R, La Bella, V., TALBOT K, A. Britton, Hunter, D.J., Orrell, R.W., Sabatelli, Mario, J. Guralnik, Bartolomei ,I, M. R. Monsurrò, Gioacchino Tedeschi, Gibbs, J. R., D. A. Stephan, Stephen Berger, SIMMONS Z, Torri, F, Singleton, A., Claudia Caponnetto, Rafferty ,I, GuralMnik ,J, GIBBS JR, CAPONETTO C, Cecilia Carlesi, RAFFERTY I, Schymick, J.C., E. Z. Oddone, Roberto Mutani, N. Washecka, Traynor, B. J., Traynor,BJ, Tedeschi, G., J. R. Gibbs, Marinou, K, Chiò, A, Fabio Giannini, Kasperaviciute ,D, GIEGER C, MARINOU K, Michael Sendtner, BRITTON A, DUNKLEY T, Dietrich A. Stephan, Gieger, C., Mancardi, G. L., S. L. Lai, Rothstein, J., CREWS C, Talbot, K., Simmons, Z., M. Sabatelli, JABONKA S, I. Bartolomei, Cynthia Crews, Hernandez, D., Berger ,S, BANDINELI S, Mora, G., Crews, C., G. L. Mancardi, Washecka ,N, WICHMANN H, Gabriella Restagno, Stephan, DA, La Bella, V, PIORO EP, FISHER EM, Wichmann, HE, H. Erich Wichmann, Lombardo ,F, Macciardi ,F, Lai, S.L., CALVO A, V. La Bella, V. L. Bella, Fung ,HC, Jinhui Ding, Kasperaviciute, D, Fisher ,EM, SCHYMICK JC, SOLA P, Bartolomei, I., Lydia Coulter Kwee, J. Raphael Gibbs, GURALNIK J, Thomas, G, Nicole Washecka, Fung, H.-C., Jessica Mandrioli, BATTISTINI, STEFANIA, M. Beck, Orrell, R. W., T. Dunkley, Hon-Chung Fung, D. Hunter, CONNOR J, Jack Guralnik, Mandrioli, J., J. Connor, Jennifer C. Schymick, R. W. Orrell, SINGLETON A, Schmidt, S., Schmidt, S, Conte, A, S. Jabonka, Elizabeth M. Fisher, Hardy, J, Angela Britton, Lombardo, F., Talbot, K, Kevin Talbot, Bruijn ,L, Giannini ,F, A. Singleton, Chanock, S. J., Stephan ,DA, Calvo, A, Pioro ,EP, SALVI F, Battistini, S, Berger, S, WICHMANN HE, MANDRIOLI J, Nalls, M., Scholz, SW, Federica Torri, SCHOLZ SW, Sabatelli, M, Traynor, BJ, Fabrizio Salvi, Jabonka, S., Berger, S., G. Siciliano, MANCARDI G, Calvo ,A, Bruijn, L, Orrell ,RW, Marcus Beck, MACCIARDI F, K. Talbot, HUNTER DJ, Siciliano, G, Washecka, N, G. Mora, Mutani ,R, Fabio Macciardi, S. J. Chanock, C. Carlesi, SCHOLZ S, Conte ,A, S. W. Scholz, Christian Gieger, Caponnetto, C, VALENTINO, Francesca, Siciliano ,G, Bartolomei, I, Talbot ,K, HERNANDEZ D, E. M. Fisher, GIANNINI, FABIO, WASHECKA N, STEPHAN DA, S. Lupoli, BRUIJN L, F. Giannini, Gabriele Siciliano, Monsurrò ,MR, Fung, H.C., Richard W. Orrell, Silke Schmidt, Oddone ,EZ, Orrell, RW, AREPALLI S, L. C. Kwee, Gilles Thomas, Torri, F., M. Nalls, Ian Rafferty, ODDONE EZ, CARLESI C, Francesca Valentino, Marinou ,K, Giannini, F, Hunter, D. J., GIANNINI F, J. Rothstein, THOMAS J, G. Thomas, THOMAS G, BANDINELLI S, Andrea Calvo, Patrizia Sola, LUPOLI S, Washecka, N., Chiò,A, Caponnetto ,C, GIBBS J, Torri ,F, Britton, A., F. Macciardi, S. Schmidt, Monsurrò, MR, Monsurro, M. R., MONSURRÒ MR, Mutani, Roberto, Calvo, Andrea, Chio', Adriano +461 more
core +2 more sources
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser +2 more
wiley +1 more source
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci [PDF]
, 2010 We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which ...
Taylor JA, Diver WR, Vermeulen, Sita H, Xifeng Wu, Allione A, Hildebrandt, MA, Hengstler JG, Besenbacher, S, Godfrey, A., Trichopoulos D, Tjonneland A, Teo MT, Nuria Malats, Koppova, Kvetoslava, Panico, S, Malcolm C Pike, Albanes, D, Prokunina-Olsson, L, Riboli, E., Baris, D, Yeager, M, Dietrich, H., Kiltie, Anne, Xu, Z, Kiemeney L, Benhamou, Simone, Allen, Naomi E, Vineis P, Fletcher T, Yuan J, Knowles, M.A., Silverman, DT, Taylor, JA, Alan Schned, Bishop, DT, Manolis Kogevinas, Mark T W Teo, Xu Z, Lloreta, J., Hutchinson A, Sanz-Velez JI, Colin P Dinney, Wheeler, William, Francisco X Real, Fletcher, T, Godfrey, Ashley, Valdivia G, Matullo, Giuseppe, Fraumeni, Joseph F, Klaus Golka, Cancel-Tassin, Geraldine, Czerniak, B., Stefansson, K, Peter Rudnai, Federico Canzian, Czerniak, Bogdan, Thun M, McGrath, Monica, Gago-Dominguez, M., Clavel-Chapelon, F, Sanchez, Manuel, Gago-Dominguez, M, Panico S, Sulem P, Chanock, Stephen J, McGrath M, Lloreta, Josep, 1958-, Mayordomo, Jose I, Dinney, Colin P, Vineis, Paolo, Ljungberg, Borje, Weinstein, SJ, Real, FX, Chatterjee N, Olivier Cussenot, H Bas Bueno-de-Mesquita, Kumar, Rajiv, Xu, Z., Tony Fletcher, Hushan Yang, Bueno-De-Mesquita, HB, Hildebrandt, M.A.T., Rothman N, Chen, Meng, Naomi E Allen, Jacobs EJ, Albanes, Demetrius, Karagas, MR, Margaret A Knowles, Mayordomo JI, Kiemeney LA, Dinney, CP, Gurzau, Eugen, Riboli, E, Riboli, Elio, Dinney CP, Chen M, Grubb R. 3rd, Baris, D., Consol Serra, Borje Ljungberg, Garcia-Closas, M., Hengstler, JG, Polidoro, S., Geraldine Cancel-Tassin, Cussenot, O, Caporaso, N., Pike, MC, Johnson, A, Real, F.X., Teo, MTW, McGrath, M., Sacerdote C, Kogevinas, M., Maria Teresa Landi, Landi, M.T., Canzian, F, Makkinje RR, Tardon, A., Johnson A, Caporaso, Neil, Stern, M.C., Cancel Tassin G, Jan G Hengstler, Caporaso N, Fulvio Ricceri, Vermeulen SH, Clavel-Chapelon, F., Lloreta J, Allen, NE, Koppova, K., Navarro, Carmen, Xu, ZL, Gapstur, SM, Schwenn, Molly, Karagas MR, Robert Grubb, Ljungberg, B, Allen NE, Sanz Velez JI, Serra, Consol, Godfrey, A, Polidoro, Silvia, Hunter, David J, María D García-Prats, Selinski, S., De Vivo, I., Prokunina Olsson L, Fu, YP, Virtamo, J., Schned, Alan, Alessandra Allione, José I Sanz-Velez, J Alfred Witjes, Garcia-Closas, R., Giuseppe Matullo, Teo, MT, Golka K, Adonina Tardón, Sanchez M, Chen, M., Van Den Berg, D, Chatterjee, N, Clavel Chapelon F, Bolick, S.C., Yang, H, Fu, Y., Mariana C Stern, Diver, W.R., Andriole, Gerald, Pike, Malcolm C, Rudnai, P, Yi-Ping Fu, Diver, W Ryan, Hunter, DJ, Grubb R 3rd, Margaret R Karagas, De Vivo, Immaculata, Kvetoslava Koppova, Besenbacher, S., Cortessis, Victoria K, Grubb R, Tjonneland, A., Stern, Mariana C, Carmen Navarro, Burdett, L., Anne Tjonneland, Andriole, G, Jacobs KB, Canzian, Federico, Fu Y, Elio Riboli, Laurie Burdett, Hengstler, Jan G, Serra, C, Karagas, Margaret R, De Vivo, I, Gapstur SM, Tardón García, Adonina, Czerniak B, Black, A, Wu, X, Baris, Dalsu, Guarrera, S, Eric J Jacobs, Teo, Mark T W, D García-Prats M, Eugen Gurzau, Taylor, Jack A, Yuan JM, Gago Dominguez M, Knowles MA, Golka, Klaus, Valdivia, Gabriel, Francoise Clavel-Chapelon, Guarrera, Simonetta, Michael Thun, Black A, García Closas R, Kiltie, Anne E, Fraumeni, JF, Benhamou, S, Lloreta, J, Besenbacher, Soren, Bolick, Sophia C E, McGrath, M, Ashley Godfrey, D García-Prats, María, Bolick, SCE, Kiltie, A.E., Kiltie AE, MA Hildebrandt, Dimitrios Trichopoulos, Cussenot, O., Wu, XF, Cancel-Tassin G, Rothman, Nathaniel, Hildebrandt MA, Rafnar, T, Trichopoulos, D., Brennan P, Virtamo J, Robert N Hoover, Purdue, Mark P, Grubb, R, Polidoro, S, Ricceri, F, Thun, M, Allen, N.E., Chanock, SJ, Allione, A., Yeager, Meredith, Thun, Michael, Porru S, Sanz-Velez, JI, Wu, X., Xu, Zongli, Jack A Taylor, Manuela Gago-Dominguez, Garcia-Closas, Montserrat, Debra T Silverman, Chatterjee, N., Monica McGrath, Koppova, K, Alison Johnson, Meng Chen, Makkinje, Remco R, Purdue, MP, Caporaso, N, Fraumeni JF Jr, Paul Brennan, Patrick Sulem, Chen, M, Brennan, P, Real FX, Trichopoulos, Dimitrios, Virtamo, Jarmo, Jacobs, E.J., Koppova K, Hildebrandt, MAT, De Vivo I, Allione, Alessandra, Purdue, M., Andriole G. Jr, Godfrey A, Brennan, Paul, Tjonneland, A, Schwenn, M, Vineis, P, Montserrat Garcia-Closas, Kiemeney, LA, Silverman, Debra T, Pike, M.C., Rajiv Kumar, Kevin B Jacobs, Schned, A., Sulem, P., Kiemeney, L.A.L.M., Sacerdote, C., Garcia Closas M, Canzian, F., Polidoro S, Zongli Xu, Hengstler, J.G., Jacobs, K.B., Baris D, Jacobs, EJ, Yang, HS, Wang, Z., Sophia C E Bolick, Black, A., Makkinje, R.R., García Closas, Montserrat, Trichopoulos, D, Katja K Aben, Berg, D.P.G. van den, Albanes, D., Jacobs, Eric J, Landi MT, Gurzau E, Kogevinas, M, Sacerdote, Carlotta, Porru, Stefano, Guarrera, S., Wang, Zhaoming, Rudnai P, Ljungberg, Börje,, Panico, Salvatore, Yang, H., Josep Lloreta, Hunter, D.J., Matullo G, Wheeler, W, Virtamo, J, Burdett, Laurie, Figueroa JD, Garcia-Prats, MD, Silverman DT, Tardón A, Jonine D Figueroa, Rafnar T, David J Hunter, Aben, K.K.H., Hoover, RN, Wang, Z, Wang, ZW, W Ryan Diver, Lloreta, Josep, Knowles, Margaret A, Wheeler, W., Prokunina-Olsson, L., D García-Prats, M, Landi, Maria Teresa, Kari Stefansson, Stephen J Chanock, Valdivia, G, Hildebrandt, Michelle AT, Bishop, David T, Joseph F Fraumeni, Figueroa, J.D., Garcia-Closas M, Ricceri, F., Immaculata De Vivo, Remco R Makkinje, Bueno de Mesquita HB, Malats, Nuria, Silvia Polidoro, Sulem, P, Pike MC, Cortessis, VK, Mayordomo, JI, Chanock, Stephen J., Mark P Purdue, Weinstein, Stephanie J, Thun, M., Hutchinson, A., Panico, S., Simone Benhamou, Chanock SJ, Bolick, SC, Bolick SC, Amanda Black, Tardon, A, Andriole G Jr, Dalsu Baris, Brennan, P., Allione, A, Hoover, Robert N, Fraumeni JF, Jian-Min Yuan, Meredith Yeager, Yeager, M., Karagas, M.R., Jose I Mayordomo, Landi, MT, Clavel-Chapelon F, Hunter DJ, Real, Francisco X, Matullo, G, Weinstein SJ, Soren Besenbacher, Hoover RN, Selinski, S, Hutchinson, A, Besenbacher S, Navarro C, Makkinje, RR, Cortessis, V.K., Rothman, N, Porru, S, Ludmila Prokunina-Olsson, Burdett, L, Andriole, G.L., Andriole G, Sacerdote, C, Malats, N., Figueroa, Jonine D, Sulem, Patrick, Prokunina-Olsson L, Anne E Kiltie, Ricceri F, Cussenot, Olivier, Stern, MC, Michelle A T Hildebrandt, Matullo, G., Johnson, A., Nilanjan Chatterjee, Kumar, R, CAPORASO, NICOLA, Tjonneland, Anne, Taylor, J.A., Kiltie, AE, Sita H Vermeulen, Demetrius Albanes, Real, Francisco X., William Wheeler, Gapstur, Susan M, Cortessis VK, Vilneis, P., Dietrich, Holger, Schwenn M, Jarmo Virtamo, Rafnar, Thorunn, Figueroa, JD, Vermeulen, SH, Bueno-de-Mesquita, H Bas, Guarrera S, Jacobs, Kevin B, Dietrich H, Cancel-Tassin, G, Dinney, C.P., Stefansson, Kari, Ricceri, Fulvio, Prokunina-Olsson, Ludmila, Serra, C., Chatterjee, Nilanjan, Grubb, R., Molly Schwenn, Vermeulen, S., Canzian F, García Prats MD, Cussenot O, Carlotta Sacerdote, Bolick, Sophia CE, Zhaoming Wang, Weinstein, S.J., Manuel Sanchez, Schwenn, M., Van Den Berg D, Hildebrandt, Michelle A T, Stern MC, Wheeler W, Clavel-Chapelon, Francoise, Rudnai, Peter, Malats N, Dietrich, H, Grubb, Robert, Bueno-De-Mesquita, H.B., Riboli E, Wu, Xifeng, Cancel-Tassin, G., Kogevinas M, Witjes, JA, Stefano Porru, Garcia-Closas, M, Gago-Dominguez M, Witjes, J Alfred, Purdue MP, Nathaniel Rothman, Simonetta Guarrera, Rafnar, T., Bishop, D.T., Garcia-Closas, R, Diver, WR, Albanes D, Fletcher, Tony, Gabriel Valdivia, Kiemeney, Lambertus A, Stefansson K, Susan M Gapstur, Aben, Katja K, Bishop DT, Yuan, JM, Victoria K Cortessis, Kogevinas, Manolis, Kumar R, Amy Hutchinson, Lambertus A Kiemeney, Bueno-de-Mesquita HB, Benhamou S, Yeager M, Witjes JA, Carrato, Alfredo, Gago-Dominguez, Manuela, Teo, M.T., Neil Caporaso, Wang Z, Ljungberg B, Wu X, Yang H, Gurzau, E, Yuan, Jian-Min, Schned, A, Serra C, Navarro, C, Reina García-Closas, Holger Dietrich, Golka, K., David T Bishop, Burdett L, Salvatore Panico, Aben, KK, Sanchez, M, Witjes, J.A., Yang, Hushan, D. García Prats M, Gapstur, S.M., Czerniak, B, Selinski, Silvia, Schned A, Silvia Selinski, Yuan, J.M., Stephanie J Weinstein, Sanz-Velez, José I, Carrato, A., Malats, N, Fu, Yi-Ping, Den Berg DV, Hutchinson, Amy, García-Closas R, Vivo ID, Knowles, MA, Thorunn Rafnar, Alfredo Carrato, Carrato, A, Johnson, Alison, Bogdan Czerniak, Gerald Andriole, Teo, Mark TW, Aben KK, Carrato A, Jacobs, KB, Mayordomo, J.I., Fletcher, T., Rudnai, P., Fu YP, Kumar, R., Paolo Vineis, Selinski S, Golka, K, David Van Den Berg, Black, Amanda, Jacobs, Eric J., Vermeulen, Sita H., Lloreta Trull, Josep, 1958-, Karagas, Margaret R., Mayordomo, Jose I., Kiltie, Anne E., Cortessis, Victoria K., Bishop, David T., Kiemeney, Lambertus A., Garcia-Closas, Reina, Stern, Mariana C., Hengstler, Jan G., Aben, Katja K., Makkinje, Remco R., Diver, W. Ryan, Witjes, J. Alfred, Silverman, Debra T., Figueroa, Jonine D., Bueno-de-Mesquita, H. Bas, Gapstur, Susan M., Sanz-Velez, Jose I., Bolick, Sophia C. E., Jacobs, Kevin B., Purdue, Mark P., Garcia-Prats, Maria D., Hunter, David J., Teo, Mark T. W., Weinstein, Stephanie J., Andriole, Gerald, Jr., Hildebrandt, Michelle A. T., Van den Berg, David, Allen, Naomi E., Taylor, Jack A., Dinney, Colin P., Fraumeni, Joseph F., Jr., Tardon, Adonina, Hoover, Robert N., Knowles, Margaret A., Grubb, Robert, III, Pike, Malcolm C. +611 more
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Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano +2 more
wiley +1 more source
A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease [PDF]
, 2015 Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs.
Seedorf, Udo, Stirrups, Kathleen E., Kleber, M.E., Mihailov, Evelin,, Zhao, Wei,, Epstein, S.E., Trompet, S., Ridker, P.M., Armasu, S., Assimes, Themistocles L., Ingelsson, E., Granger, Christopher B, Elosua, R., Rose, L., Auro, Kirsi,, Frossard, Philippe,, Boerwinkle, E., Seedorf, Udo,, Hengstenberg, Christian, Palmer, C., Peters, Annette, Stirrups, Kathleen E.,, Ripatti, Samuli,, F. Beutner (7780352), Kleber, Marcus E.,, Rose, LM, Smith, AV, K. S. Zaman (7809092), Harris, Tamara B.,, Webb, Thomas R, Armasu, Sebastian M.,, Nieminen, Markku S.,, R. Elosua (7605998), Palmer, CN, Lu, X., O'Donnell, C., Dedoussis, G., Loos, Ruth J F, Shah, Svati H, Yang, X., Franco, O.H., Chambers, John C, O'Donnell, CJ, Alver, M., Memon, FUR, G. Dedoussis (7626908), Stott, David J.,, Lu, Xiangfeng, Rose, Lynda M, Roberts, Robert, Hofman, A., P. Frossard (7605893), Smith, Albert V, Quertermous, T., V. Salomaa (7605350), Lau, King Wai, Gu, Dongfeng, L. Lind (7625984), Borecki, Ingrid B.,, Franzosi, Maria Grazia, Thompson, J., Granger, CB, Morris, A., Zalloua, Pierre A.,, P. A. Zalloua (7660361), Lu, Yingchang,, T. Kessler (7646111), Stirrups, K.E., Scholz, M, O. Gottesman (7646165), März, Winfried, E. Salfati (7780343), Mallick, N.H., Salomaa, Veikko, Hall, AS, de Vries, Paul S.,, Ingelsson, Erik, Lu, Y., Bertram, Lars, Gauguier, D, Kim, Yun Kyoung,, S. H. Shah (7627475), J. E. Buring (7809098), R. Saxena (7608878), Bjonnes, Andrew,, Karhunen, Pekka J, Hall, A., Granger, C., Assimes, Themistocles L.,, Kessler, Thorsten, Hall, L.M., Lu, Yingchang, Hopewell, Jemma C., Zhang, W., Ardissino, Diego, Reilly, Muredach P., Saxena, R, W. Zhao (696097), Iribarren, Carlos, Bjonnes, Andrew, van Zuydam, Natalie R., Franceschini, N, T. Meitinger (14191), Grace, Christopher, Cupples, L. Adrienne,, Cupples, L.A., C. B. Granger (7780361), Saleheen, Danish,, Chasman, Daniel I., Morris, AP, M. de Andrade (7646150), Zuydam, N.R. van, Franco, Oscar H.,, Kooner, J.S., Schunkert, H, Hazen, Stanley L.,, Magnusson, Patrik K., Thompson, JR, Frossard, P, Ardissino, Diego,, Sinisalo, J., N. J. Samani (7591811), Hopewell, Jemma C.,, de Andrade, Mariza, Uitterlinden, Andre, Hazen, Stanley L., Palmer, Colin N.,, Franco, Oscar H, Nelson, CP, O'Donnell, Catherine, P. K. Magnusson (7609379), Kooner, Jaspal S, Franzosi, MG, Sanghera, Dharambir K.,, Erdmann, Jeanette, Seedorf, U, Loos, Ruth J. F., Pedersen, Nancy L., Demuth, Ilja, Hall, LM, C. Iribarren (7626692), de Vries, P., Gu, D.F., Pedersen, Nancy L, Kessler, Thorsten,, Loos, RJF, Franzosi, M., Sanghera, D.K., Quertermous, Thomas, Kim, Bong-Jo,, Lu, X.F., de Andrade, M, Hall, L., CARDIoGRAMplusC4D Consortium, Nikpay, Majid, Dehghan, Abbas, Ripatti, S., J. S. Kooner (7605356), Smith, Albert V.,, Perola, Markus, Gudnason, Vilmundur,, Erdmann, J, Huang, JB, Nelson, C., Mlindgren, C, Huang, Jie,, Pervjakova, N, Lieb, W, Memon, F-U-R, Wang, Laiyuan, Feitosa, Mary F, S. Kanoni (7626542), Webb, Thomas R.,, Stott, D.J., Hengstenberg, Christian,, Huang, J., Melander, O, Qu, Liming, U. Seedorf (7602437), Magnusson, Patrik K, Gottesman, O., Samuel, M, C. J. O'Donnell (7605308), Lau, King Wai,, Schwartz, Stephen M, Nikpay, Majid,, Trompet, Stella, Jalilzadeh, Shapour,, Gu, D, D. Gu (7809095), Sinisalo, Juha,, J. W. Jukema (7625996), Marz, W, Stott, David, Hwang, Shih-Jen,, D. J. Stott (7645202), Saxena, Richa,, Palmer, CNA, H.-H. Won (7809068), de Vries, PS, Ingelsson, E, Smith, A., Memon, Fazal-ur-Rehman, D. Gauguier (7780358), Lokki, Marja-Liisa,, C. N. Palmer (7611428), S. E. Epstein (7606061), Salfati, E, Shall, A, M. G. Franzosi (7602410), de Andrade, Mariza,, Gottesman, Omri, Schwartz, Stephen M., Sanghera, Dharambir K., Kim, YK, Schwartz, SM, Hwang, S-J, Hwang, Shih-Jen, Bertram, L, C. Willenborg (7605947), Hwang, SJ, Mihailov, Evelin, Scholz, M., M. Haber (7809074), Mallick, Nadeem H.,, Elosua, Roberto, M. S. Nieminen (7605854), Sanghera, DK, Kim, Bong Jo, Feitosa, MF, A. V. Smith (7605131), Koenig, Inke R.,, Morrison, Alanna C, C. Gieger (7609259), Rose, Lynda M.,, Deloukas, P, S. M. Schwartz (7606007), Kim, Y., P. M. Ridker (7605368), Ford, Ian,, Lokki, ML, Trompet, Stella,, Salomaa, V., Andrade, M. de, Jalilzadeh, Shapour, Lieb, W., Hall, Alistair S., CARDIoGRAMplusC4D Consortium (Nikpay, M. ; Goel, A. ; Won, H. ; Hall, L.M. ; Willenborg, C. ; Kanoni, S. ; Saleheen, D. ; Gieger, C. ; Meitinger, T. ; Peters, A. ; Watkins, H. ; Kathiresan, S. ; MacPherson, R.), N. Pervjakova (7647407), Shah, S.H., Salomaa, Veikko,, Farrall, M, Wang, Laiyuan,, Jukema, J. Wouter, D. Ardissino (7605992), Rasheed, Asif, Wang, L, Beutner, F., Deloukas, Panos,, Mallick, NH, Christopher Paul Nelson (7584644), Sanghera, Dharambir K, Cupples, L, P. S. de Vries (7809119), van Zuydam, N., Lyytikainen, L-P, Schwartz, S., Zeng, Lingyao,, Meitinger, T., Lehtimaki, Terho,, Stott, David J., Franco, Oscar H., Han, Bok-Ghee, van Zuydam, NR, Won, H.H., Bottinger, EP, Goel, Anuj,, Smith, A.V., Granger, C.B., Ripatti, S, Lindgren, Cecilia M, Hengstenberg, C, Mihailov, E., W. Lieb (7412738), Pedersen, N., Chasman, DI, CHopewell, Jemma, Bjonnes, A., L. Lannfelt (7652681), Franceschini, N., Epstein, SE, Chasman, D., N. H. Mallick (7809083), Stott, D., A. Peters (6004598), Thompson, J.R., Mallick, N., Bottinger, E., Mehra, Narinder,, Pedersen, N.L., Lyytikäinen, Leo-Pekka, Qu, L., A. Rasheed (7605908), Samani, N.J., Kullo, Iftikhar J, S.-J. Hwang (7760366), Rader, Daniel J., Kathiresan, S, Granger, Christopher B.,, Salfati, Elias, Pedersen, NL, Stewart, Alexandre F., Salfati, E., Han, Bok Ghee, Kleber, Marcus E., Gauguier, D., Epstein, S., Seedorf, U., T. R. Webb (2490886), A. Bjonnes (7780337), Collins, R, MArmasu, Sebastian, S. Ripatti (7606073), K. E. Stirrups (7626839), L. Wang (2327974), Lokki, M., Hwang, S.J., D. K. Sanghera (7780373), Kim, Bong-Jo, W. Zhang (820655), Hwang, S., Huang, Jie, Sanghera, D., L. Qu (822458), Collins, R., Y. K. Kim (7626704), Goodall, A.H., Farrall, M., Han, B-G, Karhunen, Pekka J.,, Lokki, Marja Liisa, Lyytikainen, L.P., Memon, Fazal Uur Rehman, Kullo, Iftikhar J., Willenborg, Christina,, Cupples, L Adrienne, Lau, KW, Samuel, M., A. S. Hall (7605176), Cupples, L. Adrienne, D. Saleheen (7605173), Zeng, L, Morrison, A., Franco, O., Chambers, J.C., M. Nikpay (7646114), J. C. Chambers (7605185), N. R. van Zuydam (7652276), Roberts, R., Kim, Yun Kyoung, Samani, Nilesh J, Rose, L.M., A. F. Stewart (7608944), Melander, O., Franzosi, Maria Grazia,, Morrison, AC, Beutner, F, S. Trompet (7625936), Iribarren, C., M.-L. Lokki (7809080), Hazen, S.L., Palmer, C.N., Anand, Sonia S.,, Maerz, W, Stewart, A., Han, Bok-Ghee,, Ford, I., Lau, K., Gustafsson, Stefan, Loos, R., Auro, Kirsi, Gieger, Christian, CARDIoGRAMplusC4D Consortium (7809113), de Vries, Paul S, Buring, Julie E, König, Inke R., Chopewell, J, Esko, T., Scholz, Markus,, Demuth, I., Lyytikainen, Leo-Pekka,, Buring, Julie E.,, Pervjakova, Natalia, Ridker, Paul M.,, McPherson, Ruth,, Kooner, Jaspal S., Bjonnes, A, Kooner, JS, Schwartz, S.M., Stewart, AF, Stott, DJ, Nelson, C.P., Watkins, Hugh, Morrison, A.C., Grace, C, Stirrups, Kathleen, Dehghan, Abbas,, Palmer, Colin N.; id_orcid, Mehra, N., Frossard, P., Lannfelt, L, Rallidis, L., C. Grace (7809116), Saleheen, Danish, Schunkert, Heribert, Lindgren, CM, Ardissino, D, Lieb, Wolfgang, Kim, Y.K., Hall, Alistair S, Loos, R.J.F., Franzosi, M.G., Granger, Christopher B., Kathiresan, Sekar, Demuth, I, Perola, M., Haber, Marc,, Chasman, Daniel I.,, Lindgren, C., Marmasu, S, J. Erdmann (7603664), Thiery, J, O'Donnell, Christopher J.,, T. Quertermous (7626788), A. H. Goodall (7591808), Morris, A.P., Chasman, D.I., Borecki, I.B., X. Lu (2257870), Hwang, Shih Jen, K. W. Lau (7780340), Kooner, Jaspal S.,, A. P. Morris (7611419), A. C. Morrison (7625951), Lyytikainen, LP, Ripatti, Samuli, Armasu, SM, Hopewell, J.C., Danesh, John,, McPherson, R., Feitosa, M., Ridker, Paul M., Huang, Jianfeng,, Bertram, L., Jukema, J. Wouter,, Borecki, I., Samani, NJ, Meitinger, Thomas,, Danesh, J, I. J. Kullo (7646153), L.-P. Lyytikäinen (7725581), Harris, Tamara B, Zhao, W, Kathiresan, S., R. Roberts (2820928), T. Kyriakou (7774304), Zaman, Khan S, Nikpay, M., de Vries, Paul S., Pervjakova, N., Zalloua, Pierre A., Willenborg, C., Chen, Si, Rallidis, Loukianos S.,, Esko, Tonu, König, Inke R, Borecki, IB, Kathiresan, Sekar,, Gauguier, Dominique, Lehtimäki, T., Samani, N., Goel, A, Melander, Olle,, Borecki, Ingrid B., Franco Duran, OH, Qu, L, Morris, Andrew P.,, Farrall, Martin,, Rallidis, LS, M. P. Reilly (7605332), Ford, I, Goodall, AH, P. J. Karhunen (7780370), Thompson, John R.,, Lyytikäinen, Leo Pekka, Wang, L., I. R. König (7608923), Goodall, A., Boerwinkle, Eric, Thiery, J., Demuth, Ilja,, Lind, Lars, Tikkanen, E., Lannfelt, L., Kyriakou, T, Zhao, Wei, Mehra, N, Zhang, W, Boerwinkle, E, Stewart, Alexandre F.,, Stirrups, KE, M. Perola (7605860), Konig, I.R., Gieger, C, Wang, L.Y., Chen, S., Palmer, Colin N., Willenborg, Christina, Jukema, JW, Chen, Shufeng,, Goel, Anuj, Zeng, Lingyao, M. Farrall (6522599), Stirrups, K., Watkins, H., Bertram, Lars,, Nieminen, M., Memon, F., Jukema, J., M. Samuel (3483809), Danesh, J., Zhang, W.H., Anand, SS, Peters, Annette,, Kanoni, S, Ardissino, D., Kooner, J., Chasman, Daniel I, R. J. F. Loos (7725731), Nieminen, MS, Stirrups, Kathleen E, Saleheen, D, Anand, S., Salomaa, V, T. Esko (7626638), Mallick, Nadeem H., Ford, Ian, Perola, M, Nikpay, M, C. M. Lindgren (7611374), Borecki, Ingrid B, T. B. Harris (7605353), Han, BG, Gustafsson, S., Gottesman, Omri,, A. Uitterlinden (7640531), Won, H-H, Auro, K., Shah, S., Lu, Xifeng, N. Franceschini (7625954), Magnusson, PK, Elousa, R, Rasheed, A., E. Mihailov (7645184), Bottinger, Erwin P.,, Nieminen, Markku S, Koenig, Inke R., Loos, Ruth J.F., Huang, J, Shah, SH, Kanoni, S., Magnusson, P., Franco, OH, Han, B., Kullo, I.J., Hofman, Albert,, A. Metspalu (7626776), Schunkert, H., Morris, Andrew P, K. Auro (7809110), Gauguier, Dominique,, Esko, T, Buring, JE, Maerz, Winfried,, Kullo, Iftikhar J.,, Thompson, John R, Franceschini, Nora, Goel, A., Epstein, Stephen E.,, Hall, Leanne M., Thompson, John R., Uitterlinden, A, B. -.J. Kim (7809104), Lokki, Marja-Liisa, Anand, S.S., Erdmann, J., Rader, Daniel J.,, Rader, Daniel J, Yang, X, Lieb, Wolfgang,, Frossard, Philippe, Webb, Thomas R., Tikkanen, Emmi, I. Demuth (7809101), Alver, Maris, Reilly, M., Tikkanen, Emmi,, Franceschini, Nora,, Grace, Christopher,, Lund University., Zaman, K.S., Ridker, PM, Jukema, J.W., Goodall, Alison H.,, Gu, D., Consortium, C, Memon, Fazal-ur-Rehman,, T. L. Assimes (7605317), McPherson, R, Lu, Y.C., Reilly, MP, Nelson, Christopher P., Elosua, R, Rallidis, Loukianos S, Gudnason, V, Deloukas, P., Kleber, Marcus E, Cupples, L., Pervjakova, Natalia,, E. P. Bottinger (7689854), Ridker, P., Buring, J., S. Kathiresan (7606013), Mihailov, E, Dehghan, A., Qu, L.M., Collins, Rory,, Lu, Xiangfeng,, Cupples, LA, Kessler, T., Memon, F.U.R., Rose, Lynda M., Smith, Albert V., Chambers, John C., Beutner, Frank, Morris, Andrew P., Anand, Sonia S, J. C. Hopewell (7605365), L. Zeng (7646108), Uitterlinden, A., Kullo, I., Lannfelt, Lars, I. Ford (5772110), B. -G. Han (7809077), Sinisalo, Juha, Bottinger, Erwin P, Harris, TB, Rader, D., Haber, M., Deloukas, Panos, A. Goel (7602413), Lind, L, Kullo, IJ, Harris, T., Vries, P.S. de, Kanoni, Stavroula,, Saleheen, D., Stewart, A.F., Hall, Leanne M.,, Magnusson, Patrik K.,, Bottinger, Erwin P., Collins, Rory, Rader, DJ, Epstein, Stephen E, Hofman, Albert, Mehra, Narinder, Lehtimaki, T, Koenig, IR, Chen, S, Willenborg, C, Huang, Jianfeng, Perola, Markus,, Meitinger, Thomas, M. E. Kleber (7605227), Jalilzadeh, S., Hazen, Stanley, Samuel, Maria, M. Alver (7645130), A. Hamsten (7602395), Hamsten, A, Kanoni, Stavroula, Assimes, Themistocles L, Armasu, Sebastian M, Scholz, Markus, Schunkert, Heribert,, Estirrups, K, Elver, Maris, Assimes, TL, S. M. Armasu (7809107), Gottesman, O, Assimes, T., Roberts, R, Lindgren, Cecilia M.,, Karhunen, P.J., N. L. Pedersen (7609403), R. Clarke (7602407), Erdmann, Jeanette,, Shah, Svati H., Lind, Lars,, Thiery, Joachim, Nelson, Christopher P, Quertermous, Thomas,, Morrison, Alanna C.,, Beutner, Frank,, E. Tikkanen (7718189), Nieminen, M.S., Kyriakou, Theodosios,, Zalloua, P.A., Gudnason, V., van Zuydam, Natalie R, Gustafsson, Stefan,, Lindgren, Cecilia M., Lehtimaki, Terho, Karhunen, Pekka J., Hazen, Stanley L, Magnusson, P.K., Tikkanen, E, J. Thiery (7780376), Esko, Tonu,, Watkins, Hugh,, Samani, Nilesh J., Shah, Svati H.,, J. Danesh (7605383), Hofman, Bert, Jukema, J Wouter, Watkins, H, Haber, Marc; id_orcid, Buring, Julie E., Dehghan, A, Lokki, M-L, Schwartz, Stephen M.,, Feitosa, Mary F., Webb, T., Buring, J.E., Armasu, S.M., Hall, Alistair S.,, Yang, Xueli,, Hamsten, A., Salfati, Elias,, Kleber, ME, Won, Hong-Hee,, Gieger, C., Alver, M, Kleber, M., Anand, Sonia S., Iribarren, C, Armasu, Sebastian M., Chambers, J., van Zuydam, Natalie R.,, Ridker, Paul M, S. S. Anand (7609130), Y. Lu (1469287), Lhazen, S, Mallick, Nadeem H, A. Dehghan (7626011), T. Lehtimäki (3495257), S. Chen (473170), Morrison, Alanna C., O'Donnell, Christopher J., X. Yang (2201716), Kessler, T, I. B. Borecki (7685702), D. I. Chasman (7605179), J. Sinisalo (6254942), Harris, T.B., Webb, TR, Auro, K, Clarke, Robert, Chambers, John C.,, Chambers, JC, Dedoussis, George, Samuel, Maria,, Hall, Alistair, Zaman, Khan S., L. A. Cupples (7605977), L. S. Rallidis (7626911), Gieger, Christian,, Lokki, M.L., L. M. Rose (7685768), Peters, A., Won, Hong Hee, Palmer, Colin N, Nelson, Christopher P.,, Metspalu, A., Clarke, R., Qu, Liming,, de Andrade, M., Rallidis, Loukianos S., Samani, Nilesh J.,, Zaman, Khan S.,, Gu, Dongfeng,, Yang, Xueli, H. Schunkert (7603670), Metspalu, A, S. Gustafsson (7698278), Saxena, Richa, E. Boerwinkle (7609103), O. Melander (7602683), Zalloua, Pierre A, C. Hengstenberg (7603694), Harris, Tamara B., Lau, K.W., Zaman, K., Lind, L., Zhang, Weihua,, Epstein, Stephen E., Karhunen, P., Gudnason, Vilmundur, O' Donnell, CJ, Uitterlinden, André; id_orcid, Farrall, Martin, Won, H., V. Gudnason (7605347), Karhunen, PJ, Haber, Marc, Saxena, R., Rallidis, L.S., Zaman, KS, Hall, Leanne M, Won, HH, Feitosa, Mary F.,, MLindgren, Cecilia, R. Collins (7159586), Jalilzadeh, S, Roberts, Robert,, Goodall, Alison H., Clarke, R, Iribarren, Carlos,, Dedoussis, G, M. F. Feitosa (7685738), O'Donnell, C.J., Rader, D.J., Lyytikäinen, L., Uitterlinden, Andre,, Dedoussis, George,, Grace, C., Loos, Ruth J. F.,, Haber, M, Meitinger, T, Bottinger, E.P., Zhao, W., Kim, B.J., Danesh, John, Hazen, S., König, I., Kim, BJ, Han, B.G., Hengstenberg, C., Zeng, L., Assimes, T.L., März, W., Hazen, SL, Pedersen, Nancy L.,, Lu, Y, König, IR, Kim, B., R. McPherson (7605974), N. Mehra (7809086), Lu, X, Rasheed, Asif,, D. J. Rader (7605215), Peters, A, Kyriakou, Theodosios, Thiery, Joachim,, Yang, X.L., Feitosa, M.F., Lannfelt, Lars,, McPherson, Ruth, Melander, Olle, P. Deloukas (7603691), Reilly, Muredach P, Lindgren, C.M., J. Huang (2342368), S. Jalilzadeh (7785812), Quertermous, T, E. Ingelsson (7605335), Alver, Maris,, Zhang, Weihua, O. H. Franco (7625993), Nieminen, Markku S., Sinisalo, J, Hofman, A, A. Hofman (4269889), Hopewell, Jemma C, H. Watkins (7602419), L. M. Hall (7809071), Hall, A.S., S. L. Hazen (7668347), Won, Hong-Hee, J. R. Thompson (6440546), W. März (7609394), Hopewell, JC, Trompet, S, Gustafsson, S, Kyriakou, T., Zalloua, PA, Stewart, Alexandre F, L. Bertram (3538832), M. Scholz (7780346), Elosua, Roberto,, Hamsten, Anders,, Chen, S.F., Maerz, Winfried, Webb, T.R., Chen, Shufeng, Ingelsson, Erik,, Hopewell, J., Rasheed, A, Metspalu, Andres,, Zalloua, P., Kim, B-J, Goodall, Alison H, Boerwinkle, Eric,, F.-U.-R. Memon (7809089), Clarke, Robert,, Hamsten, Anders, Reilly, M.P., Metspalu, Andres +928 more
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales +11 more
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
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Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan +16 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley +13 more
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Genome-wide significance for dense SNP and resequencing data.
, 2008 The problem of multiple testing is an important aspect of genome-wide association studies, and will become more important as marker densities increase.
Whittaker, John C, De Iorio, Maria, Hoggart, Clive J, Clark, Taane G, Balding, David J +4 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra +16 more
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